Potential antiviral agents of <i>Rosmarinus officinalis</i> extract against herpes viruses 1 and 2

Al-Megrin, Wafa Abdullah I.; AlSadhan, Norah A.; Metwally, Dina M.; Al-Talhi, Razan; El‐Khadragy, Manal F.; Abdel-Hafez, Lina Jamil M

doi:10.1042/bsr20200992

Cited by 23 publications

(13 citation statements)

References 26 publications

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“…In our experiment, rosemary extract displayed antifungal action against A. niger at concentrations ranging from 25 to 90%, which is consistent with the findings of Swari et al [ 57 ], who demonstrated that rosemary ethanol extract had an inhibitory effect against Candida albicans . Rosemary extract had antiviral efficacy against HSV-1 and HSV-2, according to Al Mergin et al [ 3 ]. Moreno et al [ 20 ] proposed that the antibacterial efficiency of rosemary extracts was linked to their unique phenolic makeup, with antimicrobial action attributed mostly to carnosic acid and rosmarinic acid.…”

Section: Resultsmentioning

confidence: 99%

“…It has been used as a stimulant, as an analgesic, and against inflammatory diseases, physical and mental fatigue in traditional medicine [ 1 ]. The pharmacologically validated medicinal properties of rosemary include antibacterial and antioxidant [ 1 , 2 ], antiviral [ 3 ], anti-inflammatory [ 4 ], antifungal [ 5 ], and antiproliferative effects toward cancer cells, absence of genotoxicity, and the ability to prolong thrombin time [ 6 ]. The antidepressant properties have been studied in various models [ 7 , 8 ]; we have earlier shown that rosemary infusion has antidepressant/anxiolytic-like and anticholinesterase effects [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Rosemary Extract and Essential Oil as Drink Ingredients: An Evaluation of Their Chemical Composition, Genotoxicity, Antimicrobial, Antiviral, and Antioxidant Properties

Christopoulou

Androutsopoulou

Hahalis³

et al. 2021

Foods

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Rosmarinus officinalis L. (rosemary) is in high demand in the food and drink industries due to its distinct organoleptic properties. With the aim of evaluating the rosemary leaves as drink ingredients, both the essential oil and alcoholic (38%, v/v) extract were studied in terms of chemical composition, genotoxicity, antimicrobial, antiviral, and antioxidant properties. GC–MS analysis showed that the main volatile compounds in the essential oil were eucalyptol (40.1%), camphor (12.4%), and α-pinene (12.9%). LC–MS analysis revealed gallocatechin and rosmarinic acid as the main extract ingredients. Both the essential oil and the extract were not genotoxic (Ames test) against TA98 and TA100 at the dilutions of 5% and 90%, respectively; those dilutions were selected as the maximum possible ones in the drink industry. Their activity was investigated against Escherichia coli, Salmonella enterica serovar Typhimurium, Staphylococcus aureus, Aspergillus niger, and Adenovirus 35. Both were effective against Adenovirus and A. niger, even the essential oil at 5% (v/v). The extract at dilutions of 25–90% had more pronounced activity against tested bacteria than the essential oil at the dilutions of 5–100%; the essential oil at the dilution of 5% inhibited S. aureus growth. The antioxidant activity was evaluated by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay, the 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid decolorization assay, and the ferric reducing antioxidant power assay. Both exhibited good antioxidant activity, but rosemary essential oil was far more effective than the extract. Our results demonstrate that rosemary essential oil and extract are safe and have beneficial biological properties. Therefore, they could serve as health-promoting ingredients in the drink industry.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rosemary Extract and Essential Oil as Drink Ingredients: An Evaluation of Their Chemical Composition, Genotoxicity, Antimicrobial, Antiviral, and Antioxidant Properties

Christopoulou

Androutsopoulou

Hahalis³

et al. 2021

Foods

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“…They showed that 17 (85%) of the total P. aeruginosa isolates could produce biofilm. Rosemary extract was the most useful extract in biofilm inhibition, inhabiting 83% of P. aeruginosa biofilm (25). According to the chemical analysis, the antimicrobial compounds of the Rosmarinus mainly included thymol, flavonoids, triterpenoids, and other compounds with the nature of a phenolic or free hydroxyl group, all known as the most active antimicrobial and antibiofilm compounds.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antimicrobial Activity and Anti-Quorum Sensing of Rosmarinus Methanol Extract on Pseudomonas aeruginosa

et al. 2021

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Background: The increasing infections caused by resistant P. aeruginosa strains originate from hospitals. Therefore, many efforts are being made to find new herbal compounds as suitable substitutes for antibiotics. Objectives: The present study aimed to evaluate the antibacterial and anti-quorum activity of Rosmarinus methanol extract on P. aeruginosa. Methods: This experimental study was performed on standard and clinical strains of P. aeruginosa. The methanolic extract of Rosmarinus was prepared by the Soxhlet method, and the antimicrobial activity of the extract was evaluated by diffusion method in wells and microdilution. We examined the effect of this extract on the antibiofilm activity, protease, and pyocyanin production of P. aeruginosa in order to investigate the anti-quorum sensing activity of methanolic extract of Rosmarinus. Via SPSS 17, we managed to conduct the statistical analysis. Results: The mean diameter of growth inhibition zone obtained from methanolic extract of rosemary at a concentration of 500 mg/ml on Pseudomonas aeruginosa was 18.5 mm, and the minimum inhibitory concentration of methanolic extract of rosemary was 125 mg / ml for bacteria. Extract at concentrations higher than 62.5 mg /ml prevented biofilm formation, protease, and the pyocyanin production of P. aeruginosa. Conclusions: The results of the present study can be a valuable report on their useful role in infection control because the methanol extracts of Rosmarinus had suitable antibacterial and anti-quorum sensing activity. It is suggested that more studies be conducted on the identification of antimicrobials as a suitable alternative for antibiotics in the treatment of diseases.

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“…Another important species of Lamiaceae family is Rosmarinus officinalis, which is widely used in treatment of rheumatic pain, headache, hysteria, stomachache, depression and infectious diseases (Ghasemzadeh Rahbardar et al 2020). A study reported that extract of R. officinalis, exhibited potential antiviral activity against HSV-1 and HSV-2, which this extract at the concentration of 30 μg/ml inhibited the 55% of HSV-1 and at 40μg/ml inhibited the 65% of HSV-2 plaques and extract of R. officinalis showed the significant inhibitory effect at the 50 μg/ml concentration two HSV serotypes (Al-Megrin et al 2020).…”

Section: Lamiaceaementioning

confidence: 96%

The Antiviral Potential of Iranian Herbal Pharmacopoeia (IHP) on Herpes Simplex Viruses (HSV): A Review Article

Gavanji¹

2022

BIOMEDNATPROCH

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Herpes Simplex Viruses (HSV) viruses are highly contagious that commonly cause dermatitis, encephalitis, meningitis and genitourinary infections and also can lead to cervical cancer. For treatment of HSV infections, several physical methods and antiviral drugs are introduced, antiviral medications can also prevent or reduce outbreaks. The use of herbal medicine with antiviral effects attracted worldwide attentions. The aim of this review article is to introduce the Iranian Herbal Pharmacopoeia (IHP) with antiviral potential against two HSV serotypes and help to evaluate and develop the new drugs from natural sources. To provide this review, relevant articles in some authentic databases including PubMed, Web of Science, Science Direct, Scopus, Google Scholar and SID (scientific information database), from 1967 to April 2022 were collected, and selected botanicals from (IHP) with their scientific names and classifications and their outcome (CC50 and IC50) were introduced. In this review, scientific data regarding anti-herpetic activities of Iranian Herbal Pharmacopoeia (IHP) showed that 34 herbs from 17 families have antiviral potential to inhibit two HSV serotypes. According to families, Lamiaceae family has the highest percentage (29.41 %) of plants with antiviral activity against two HSV serotypes, also review of recent data showed that Salvia officinalis, Melissa officinalis, Securigera Securidaca, Hyssopus officinalis, Quercus brantii, Artemisia aucheri and Curcuma longa have remarkable antiviral activity against two HSV serotypes. Results of this review suggest that further research to identify and purify the bioactive compounds to determine the molecular mechanisms of action is needed.

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Potential antiviral agents of Rosmarinus officinalis extract against herpes viruses 1 and 2

Cited by 23 publications

References 26 publications

Rosemary Extract and Essential Oil as Drink Ingredients: An Evaluation of Their Chemical Composition, Genotoxicity, Antimicrobial, Antiviral, and Antioxidant Properties

Rosemary Extract and Essential Oil as Drink Ingredients: An Evaluation of Their Chemical Composition, Genotoxicity, Antimicrobial, Antiviral, and Antioxidant Properties

Evaluation of Antimicrobial Activity and Anti-Quorum Sensing of Rosmarinus Methanol Extract on Pseudomonas aeruginosa

The Antiviral Potential of Iranian Herbal Pharmacopoeia (IHP) on Herpes Simplex Viruses (HSV): A Review Article

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