Potential Antiviral Lignans from the Roots of <i>Saururus chinensis</i> with Activity against Epstein–Barr Virus Lytic Replication

Cui, Hui; Xu, Baojun; Wu, Taizong; Xu, Jing; Yuan, Yan; Gu, Qiong

doi:10.1021/np400757k

Cited by 58 publications

(57 citation statements)

References 37 publications

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“…The known compounds were identified as barbatellarine B (14), 19 scutebarbatine Y (15), 18 barbatin D (16), 20 scutebarbatine L (17), 21 6,7-di-O-acetoxbarbatin A (18), 22 scutebarbatine A (19), 11 scutebata J (20), 23 scutebarbatine K (21), 21 scutebata D (22), 8 scutebata F (23), 8 barbatine D (24), 11 barbatine A (25), 11 and barbatine B (26), 11 based on spectroscopic data analysis and comparison with literature values.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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neo-Clerodane Diterpenoids from Scutellaria barbata with Activity against Epstein–Barr Virus Lytic Replication

Wang

Jiang

et al. 2015

J. Nat. Prod.

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Bioassay-guided fractionation was conducted on an EtOAc-soluble extract of the whole plants of Scutellaria barbata, monitored by inhibition of Epstein-Barr virus (EBV) lytic replication. Twenty-six neo-clerodane diterpenoids were isolated, of which 13 are new (1-13, scutolides A-L) and 13 previously known (14-26). The structures of 1-13 were elucidated by analysis of their NMR and MS spectroscopic data. Furthermore, the configurations of the new compounds 1 and 11 were confirmed by single-crystal X-ray diffraction. All of the isolated compounds were evaluated for inhibitory effects against EBV lytic replication. Eleven compounds (3, 4, 6, 11, 12, 15, 16, 17, 20, 22, and 24) exhibited moderate to potent inhibition, with EC50 values from 3.2 to 23.6 μM and selective index (SI) values from 2.1 to 109.2. More specifically, the new compound 4 showed the most potent activity, with EC50 and SI values of 3.2 μM and 46.1, respectively, while compound 24 (EC50 = 16.4 μM) exhibited the highest SI of 109.2. This study is the first to report that neo-clerodane diterpenoids demonstrate significant inhibition against EBV lytic replication.

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Section: ■ Results and Discussionmentioning

confidence: 99%

“…(+)-Rutamarin was used as control. 24 Among them,11 compounds (3,4,6,11,12,[15][16][17]20,22,and 24) exhibited more than 50% inhibition against EBV lytic replication. These 11 compounds were further analyzed to obtain their EC 50 , CC 50 , and SI values ( Table 4).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

neo-Clerodane Diterpenoids from Scutellaria barbata with Activity against Epstein–Barr Virus Lytic Replication

Wang

Jiang

et al. 2015

J. Nat. Prod.

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“…To firmly establish the antiviral activity and adverse reactions like reactogenecity or toxicity of the purified phytomolecules, appropriate in vivo studies (animal models) and subsequent clinical trials are necessary. A bioactive flavonoid 'Baicalein' isolated from Chinese medicinal plant Scutellaria baicalensis Georgi showed antiviral properties using high-speed counter-current chromatography (HSCCC) technique [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58].…”

Section: Antiviral Molecules Of Plant Originmentioning

confidence: 99%

Antiviral Phytochemicals: An Overview

Kapoor¹,

Sharma²,

Kanwar³

2017

Biochem Physiol

100

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The pandemic of viral diseases during recent years has forced the scientific community to investigate less toxic antiviral phytomolecules instead of using nucleic acid analogues, protease inhibitors or other toxic synthetic molecules as antiviral therapeutics. Plants and many of their secondary metabolites because of the healing properties have been in traditional use throughout the world since ancient times. They provide us diverse bioactive phytochemicals which play synergetic role in maintaining human health. The development of clinical products from phyto-pharmaceuticals is a trending approach to look for ecofriendly therapeutic molecules. More than 50% of drugs used in Western nations are derived from plants or their constituents. Many plants have significant antiviral properties too. Very little information is available about plants of antiviral significance. This article briefly reviews various phytochemicals/bioactive molecules which have been isolated from plants and possess antiviral constituents, their mode of action and potential applications in treating/preventing viral diseases.

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“…Additionally, the presence of methoxyl groups was confirmed by the presence of an intense peak at δ 55. 9 (> 300 µmol L -1 ) to all tested cells. Due to the structural similarities between compounds 1-3, it is interesting to observe that the presence of methylenedioxyl group in both aromatic rings, as in the case of compound 1, cause a reduction in the cytotoxic potential.…”

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confidence: 90%

ISOLATION OF CYTOTOXIC NEOLIGNANS FROM Saururus cernuus L. (SAURURACEAE) USING IONIC LIQUID IN THE MICROWAVE ASSISTED EXTRACTION (MAE)

Brito¹,

Camilo²,

Figueiredo³

et al. 2018

Quim. Nova

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In the present work, dried leaves of Saururus cernuus (Saururaceae) were subjected to extraction using an ionic liquid (1-butyl-3-methylimidazolium bromide -BMImBr) in the microwave assisted extraction (MAE). The obtained extract was partitioned using n-hexane and cytotoxicity activity of this organic phase against murine melanoma cell line (B16F10-Nex2) was evaluated in vitro. Since this extract displayed activity (100% of cell death at 200 µg mL -1 ) it was subjected to a bioactivity-guided fractionation to afford four related neolignans: threo-austrobailignan-5 (1), threo-austrobailignan-6 (2), threo-dihydroguaiaretic acid (3) and saucernetin (4). Their chemical structures were established based on NMR and MS spectral analysis. Among the isolated neolignans, compound 2 exhibited the highest cytotoxic activity against HeLa (human cervical melanoma) cells with IC 50 of 28.3 ± 3.9 µg mL ). The obtained results provide important data for the selection of bioactive neolignans with promising cytotoxic potential using a simple and fast method employing a green solvent as 1-butyl-3-methylimidazolium bromide (BMImBr).

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Potential Antiviral Lignans from the Roots of Saururus chinensis with Activity against Epstein–Barr Virus Lytic Replication

Cited by 58 publications

References 37 publications

neo-Clerodane Diterpenoids from Scutellaria barbata with Activity against Epstein–Barr Virus Lytic Replication

neo-Clerodane Diterpenoids from Scutellaria barbata with Activity against Epstein–Barr Virus Lytic Replication

Antiviral Phytochemicals: An Overview

ISOLATION OF CYTOTOXIC NEOLIGNANS FROM Saururus cernuus L. (SAURURACEAE) USING IONIC LIQUID IN THE MICROWAVE ASSISTED EXTRACTION (MAE)

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