Potential Application of Lonicera japonica Extracts in Animal Production: From the Perspective of Intestinal Health

Abstract

Lonicera japonica (L. japonica) extract is rich in active substances, such as phenolic acids, essential oils, flavones, saponins, and iridoids, which have a broad spectrum of antioxidant, anti-inflammatory, and anti-microbial effect. Previous studies have demonstrated that L. japonica has a good regulatory effect on animal intestinal health, which can be used as a potential antibiotic substitute product. However, previous studies about intestinal health regulation mainly focus on experimental animals or cells, like mice, rats, HMC-1 Cells, and RAW 264.7 cells. In this review, the intestinal health benefits including antioxidant, anti-inflammatory, and antimicrobial activity, and its potential application in animal production were summarized. Through this review, we can see that the effects and mechanism of L. japonica extract on intestinal health regulation of farm and aquatic animals are still rare and unclear. Further studies could focus on the regulatory mechanism of L. japonica extract on intestinal health especially the protective effects of L. japonica extract on oxidative injury, inflammation, and regulation of intestinal flora in farm animals and aquatic animals, thereby providing references for the rational utilization and application of L. japonica and its extracts in animal production.

Intrauterine Growth Retardation Affects Intestinal Health of Suckling Piglets via Altering Intestinal Antioxidant Capacity, Glucose Uptake, Tight Junction, and Immune Responses

“…In addition, the immune and inflammatory response is closely associated with intestinal barrier function [ 52 , 53 ]. sIgA, an immunoglobulin secreted by plasma cells of the intestinal mucosa, is a major effector of the intestinal mucosal immunity, which acts as the first defense line to prevent the colonization of pathogens in the intestinal mucosa and plays an important role in local anti-infection of the body [ 24 , 54 ]. Our results from the present study showed that the sIgA content in jejunum mucosa significantly decreased when piglets suffered from IUGR, which indicated that IUGR damages the intestinal immune function.…”

Fecal Microbial Changes in Response to Finishing Pigs Directly Fed With Fermented Feed

“…The gut microbiota maintains a symbiotic relationship with the host and regulates several important functions including host metabolism, nutrients digestion and absorption, immunity, and intestinal barrier function (5,29). So, the dynamic balance of intestinal microbiota is crucial for animal intestinal health, while optimum intestinal health is crucial to animal growth and health (30,31).…”

“…Maintaining the dynamic balance of intestinal microbiota is of prime importance to animal growth and health. However, many factors can cause microbial imbalances in the gastrointestinal tract, which may seriously affect nutrients' utilization and host health (3)(4)(5). Gut microbiota diversity and composition in humans as well in animals can be modulated by nutritional strategies, such as changes in dietary composition and the addition of feed additives (3,6,7).…”

Lonicerae Japonicae Flos Extract Promotes Sleep in Sleep-Deprived and Lipopolysaccharide-Challenged Mice

“…To date, more than 300 compounds from the LJF extract including volatile oils, organic acids, and flavonoids have been identified ( Tang et al, 2021 ). Chlorogenic acid and luteolin are used as quality control standards for the characterization of medical materials ( Yuan et al, 2014 ).…”