Potential applications of fluorhydroxyapatite as biomaterials in medicine

Vitkovič, Martin; Noaman, Maha S. M.; Palou, Martin; Jantová, Soňa

doi:10.2478/s11532-009-0010-6

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…Presumably, this is due to the lowest solubility, good chemical stability of FA and toxicity of high amounts of fluorides. However, attempts to test FA-containing formulations (Gineste et al 1999 ; Agathopoulos et al 2003 ; Yoon et al 2005 ; Bogdanov et al 2009 ; Nordquist et al 2011 ), ion-substituted FA (Kheradmandfard et al 2012 ; Sharifnabi et al 2014 ), FHA (Savarino et al 2003 ; Vitkovič et al 2009 ) and porous FA bioceramics (Chaari et al 2009 ) are kept performing. The effect of fluoride contents in FHA on both osteoblast behavior (Qu and Wei 2006 ; Bhadang et al 2010 ) and leukemia cells proliferation (Theiszova et al 2008 ) has been described.…”

Section: The Members Of Capo 4 Familymentioning

confidence: 99%

Calcium orthophosphates (CaPO4): occurrence and properties

Dorozhkin¹

2015

Prog Biomater

214

141

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The present overview is intended to point the readers’ attention to the important subject of calcium orthophosphates (CaPO4). This type of materials is of the special significance for the human beings because they represent the inorganic part of major normal (bones, teeth and antlers) and pathological (i.e., those appearing due to various diseases) calcified tissues of mammals. For example, atherosclerosis results in blood vessel blockage caused by a solid composite of cholesterol with CaPO4, while dental caries and osteoporosis mean a partial decalcification of teeth and bones, respectively, that results in replacement of a less soluble and harder biological apatite by more soluble and softer calcium hydrogenorthophosphates. Therefore, the processes of both normal and pathological calcifications are just an in vivo crystallization of CaPO4. Similarly, dental caries and osteoporosis might be considered as in vivo dissolution of CaPO4. In addition, natural CaPO4 are the major source of phosphorus, which is used to produce agricultural fertilizers, detergents and various phosphorus-containing chemicals. Thus, there is a great significance of CaPO4 for the humankind and, in this paper, an overview on the current knowledge on this subject is provided.

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Section: The Members Of Capo 4 Familymentioning

confidence: 99%

Calcium orthophosphates (CaPO4): occurrence and properties

Dorozhkin¹

2015

Prog Biomater

214

141

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“…Due to its low solubility, good chemical stability and the toxicity of high amounts of fluorides, chemically pure FA is rarely used as a bone substituting material 442 . However, various FA-containing composites, 443 - 445 FHA 446 , 447 and porous FA bioceramics 448 seem to be better candidates for biomedical applications. Furthermore, due to the ability to form FHA and/or HFA, minor amounts of fluorides might be intentionally added to calcium orthophosphate biomaterials 449 - 455 .…”

Section: The Members Of the Calcium Orthophosphate Familymentioning

confidence: 99%

Calcium orthophosphates

2011

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The present overview is intended to point the readers’ attention to the important subject of calcium orthophosphates. This type of materials is of special significance for human beings, because they represent the inorganic part of major normal (bones, teeth and antlers) and pathological (i.e., those appearing due to various diseases) calcified tissues of mammals. For example, atherosclerosis results in blood vessel blockage caused by a solid composite of cholesterol with calcium orthophosphates, while dental caries and osteoporosis mean a partial decalcification of teeth and bones, respectively, that results in replacement of a less soluble and harder biological apatite by more soluble and softer calcium hydrogenphosphates. Therefore, the processes of both normal and pathological calcifications are just an in vivo crystallization of calcium orthophosphates. Similarly, dental caries and osteoporosis might be considered an in vivo dissolution of calcium orthophosphates. Thus, calcium orthophosphates hold a great significance for humankind, and in this paper, an overview on the current knowledge on this subject is provided.

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“…Presumably, this is due to the lowest solubility, good chemical stability of FA and toxicity of high amounts of fluorides. However, attempts to test FA-containing formulations (Gineste et al 1999;Agathopoulos et al 2003;Yoon et al 2005;Bogdanov et al 2009;Nordquist et al 2011), ion-substituted FA (Kheradmandfard et al 2012;Sharifnabi et al 2014), FHA (Savarino et al 2003;Vitkovič et al 2009) and porous FA bioceramics (Chaari et al 2009) are kept performing. The effect of fluoride contents in FHA on both osteoblast behavior (Qu and Wei 2006;Bhadang et al 2010) and leukemia cells proliferation (Theiszova et al 2008) has been described.…”

Section: Fa (Or Fap)mentioning

confidence: 99%