Potential applications of hormones to plant and animal tissues as food

Haard, Norman F.; Schwimmer, Sigmund

doi:10.1080/10408397109527126

Cited by 4 publications

(3 citation statements)

References 245 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This picture was very different from that described by Heard & Stewart (1971) since their rats had low basal blood glucose. Conversely our results were very similar to the glucose status of children in developing countries (Brasel, 1980).…”

Section: Efsect Of Pea4 During Pregnancy and Lactationcontrasting

confidence: 87%

“…Maternal lactation is also very important for body and pancreatic growth in rats (Crnic & Chase, 1978;Beck et al 1982). When undernourished rats born from normal and undernourished mothers were compared, the postweaning carbohydrate status was found to be worse in the latter rats (Heard & Stewart, 1971). In order to improve our understanding of pancreatic adaptation in children from developing countries and changes in glucose homeostasis after rehabilitation, we used, as a model, rats born from mothers undernourished during both pregnancy and (1985).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Protein–energy malnutrition in pregnant rats improves the adaptation of the endocrine pancreas in malnourished offspring and induces insulin resistance after rehabilitation

et al. 1987

View full text Add to dashboard Cite

1. In developing countries, malnutrition begins during pregnancy and lactation. Glucose intolerance is a problem of importance during protein-energy malnutrition (PEM). We therefore studied glucose homeostasis in rats weaned from undernourished mothers.2. On weaning, 156 mde Wistar rats, born from deprived mothers (75 g casein/kg diet), were fed ad lib on either a balanced diet (180 g casein/kg; group DR), or a protein-deficient diet (50 g casein/kg; group DD). At seven time intervals (weeks 0, 1, 3, 5, 8, 16 and 23) twelve rats were weighed, fasted overnight and then decapitated. Blood glucose, plasma insulin (IRI) and glucagon (IRG) levels and pancreatic insulin and glucagon contents were determined.3. In DR and DD rats blood glucose, which was normal at weaning, dropped in the 1st week and then increased slowly. DR rats were hyperglycaemic from week 16. IRI continually increased during the experiment from nearnormal values to hyperinsulinic levels in DR rats; in group DD, it remained stable until week 8 before increasing. IRG, which was very low at weaning, increased to normal levels in the 1st week in group DR; in group DD, it fell slightly during the study. Pancreatic hormone contents were much higher than after normal pregnancy and lactation.4. We compared these results with those of a previous study with rats born from normal mothers: at weaning in the second experiment the rats were already well adapted to malnutrition. The plasma ratio IRI: IRG in DD rats showed two phases of adaptation: weeks 0-5 when glucose homeostasis did not change and weeks 5-23 when it became increasingly normal. At the end of the experiment DR rats still had a lower body-weight than normal rats but were insulin-resistant.

show abstract

Section: Efsect Of Pea4 During Pregnancy and Lactationcontrasting

confidence: 87%

mentioning

confidence: 99%

Protein–energy malnutrition in pregnant rats improves the adaptation of the endocrine pancreas in malnourished offspring and induces insulin resistance after rehabilitation

et al. 1987

View full text Add to dashboard Cite

show abstract

“…Endocrine glands and their secretions are altered by malnutrition (Platt & Stewart 1962. 1967: Heard & Stewart, 1971 and it is likely that correcting the food deficiencies when growth is becoming dominant (the last third of gestation) has led to an overgrowth. The thyroid gland is known to be depressed by malnutrition (Platt & Stewart, 1962) and giving small (physiological) doses of thyroxine to a malnourished pregnant rat leads to the birth of full-sized young (Soerjodibroto ef al.…”

Section: Discussionmentioning

confidence: 99%

The effect of rehabilitation at different stages of development of rats marginally malnourished for ten to twelve generations

et al. 1980

View full text Add to dashboard Cite

I . Rats which have been maintained for ten to twelve generations on diets of low protein value were rehabilitated in utero (group P), from birth (group F) and from 4 weeks of age (group W).2. Group W showed little change in physique, behaviour or learning, indicating that for recovery to be effective refeeding must begin earlier.3. Group F just failed to attain full physical recovery (90%) whereas group P overgrew by 18.6% in weight and 8.5 O; in length. 4.In a test designed to evaluate learning ability rehabilitated rats of groups P and F were significantly less successful than normal rats, but more successful than rats of group W or rats of the original undernourished colony. .Rehabilitation for a further two generations in groups F and P corrected any residual physical and behavioural defects but produced no further improvement on the Lashley ( I 938) jumping platform.The changes produced in rats by several generations of marginal protein-energy deficiency have been reported earlier (Stewart, 1970;Stewart & Sheppard, 1971; Stewart e f al. 1975). There would appear to be a rapid adaptation in size and shape which stabilizes after two or three generations at a level probably controlled by the severity of the dietary deficiency. The adult males of the deficient colonyweighed approximately40 yo less than thewell-fedcontrols, and the females 30 yo less. Body lengths were reduced by 12 and 8 yo respectively and this was also the deficit in femur length. Brain weights were reduced by approximately 4-5 %.

show abstract

Membrane Structure and Cellular Death in Biological Tissue

Haard

1972

Journal of Food Science

View full text Add to dashboard Cite

Potential applications of hormones to plant and animal tissues as food

Cited by 4 publications

References 245 publications

Protein–energy malnutrition in pregnant rats improves the adaptation of the endocrine pancreas in malnourished offspring and induces insulin resistance after rehabilitation

Protein–energy malnutrition in pregnant rats improves the adaptation of the endocrine pancreas in malnourished offspring and induces insulin resistance after rehabilitation

The effect of rehabilitation at different stages of development of rats marginally malnourished for ten to twelve generations

Membrane Structure and Cellular Death in Biological Tissue

Contact Info

Product

Resources

About