Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Cimponeriu, Danut; Serafinceanu, Cristian; Apostol, Pompilia; Toma, M.; Stavarachi, Monica; Radu, I.; Craciun, Anne M.; Spandole, Sonia; Panduru, Nicolae; Rusu, Lavinia; Șchiopu, Oana; Ion, Daniela Adriana

doi:10.2478/s11535-013-0178-1

Cited by 5 publications

(5 citation statements)

References 75 publications

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“…TTV DNA was more prevalent among obese women without other comorbidities (Pearson’s Chi squared p = 0.024); also BMI of individuals positive for TTV DNA was overall higher than the BMI of TTV DNA-negative individuals (independent sample T-test p = 0.03), nevertheless both observations failed to reach statistical significance following Bonferroni correction. These findings could support and come in addition to previous reports of TTV DNA being more frequent with borderline statistical significance ( p = 0.046) in obese women compared to matched controls [ 27 ].…”

Section: Discussionsupporting

confidence: 90%

Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies

Spandole-Dinu

Cimponeriu

Crăciun³

et al. 2018

BMC Infect Dis

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BackgroundHuman anelloviruses (TTV, TTMDV and TTMV) are at high prevalence all across the globe, having also a controversial disease-inducing potential. This study aimed to estimate the prevalence of anelloviral DNA in the Romanian human population and to investigate the association of infections with common pathologies in Romanian population.MethodsAfter informed consent, blood samples were collected from 2000 subjects represented by: clinically healthy individuals (n = 701) and a group of patients with pathologies linked to low grade inflammation or alteration of carbohydrate metabolism (n = 1299). All samples were analysed for the presence of TTV, TTMDV and TTMV DNA by hemi-nested PCR.ResultsThe prevalence of TTV, TTMDV and TTMV in the studied population was 68.2, 54.4%, respectively 40.1%, lower than the recent reports from other geographic regions. The three viral species were significantly more frequent in the group of patients compared to the healthy subjects and were associated with type 2 diabetes mellitus. The presence of anelloviral DNA was also associated with medical procedures (e.g. haemodialysis/transfusions, surgical procedures) and previous hepatitis A virus infection. Lifestyle choices related to alcohol consumption, smoking, physical activity and living environment were not associated with differences in distribution of the three viruses.ConclusionFurther evidence is needed to establish a correlation between infection with human anelloviruses and a pathology or group of pathologies.

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Section: Discussionsupporting

confidence: 90%

Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies

Spandole-Dinu

Cimponeriu

Crăciun³

et al. 2018

BMC Infect Dis

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“…Similar to our findings here, a number of studies failed to find a significant relationship between TTV prevalence and subject characteristics in other countries, including Egypt [41], Russia [42], Brazil [40], Iran [23] and Qatar [10]. Conversely, a number of studies reported a significant association between TTV prevalence and subject attributes in other countries, including: gender [sic] in the UAE [43]; blood transfusion history in Iran [23]; age in the UK [44], China [19], Brazil [40] and Qatar [10]; and obesity in Romanian women [45].…”

Section: Discussionmentioning

confidence: 99%

The Molecular Epidemiology and Phylogeny of Torque Teno Virus (TTV) in Jordan

Sarairah

Bdour

Gharaibeh

2020

Viruses

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Torque teno virus (TTV) is the most common component of the human blood virobiota. Little is known, however, about the prevalence of TTV in humans and the most common farm domesticates in Jordan, or the history and modality of TTV transmission across species lines. We therefore tested sera from 396 Jordanians and 171 farm animals for the presence of TTV DNA using nested 5′-UTR-PCR. We then performed phylogenetic, ordination and evolutionary diversity analyses on detected DNA sequences. We detected a very high prevalence of TTV in Jordanians (~96%); much higher than in farm animal domesticates (~29% pooled over species). TTV prevalence in the human participants is not associated with geography, demography or physical attributes. Phylogenetic, ordination and evolutionary diversity analyses indicated that TTV is transmitted readily between humans across the geography of the country and between various species of animal domesticates. However, the majority of animal TTV isolates seem to derive from a single human-to-animal transmission event in the past, and current human-animal transmission in either direction is relatively rare. In conclusion, animal TTV in Jordan is historically derived from human variants; however, ongoing human-animal TTV exchange is minimal and zoonotic infection seems to be of limited importance.

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“…In some cases, TTV was also detected in human lip and kidney tumors [ 103 ]. In studies, TTV load in women with breast cancer showed a significant increase compared to healthy women [ 104 ]. The DNA of TTV has also been identified in the neoplastic tissue of lung cancer and brain tumors, but it is not possible to talk about their relationship with certainty.…”

Section: Human Cancermentioning

confidence: 99%

The mysterious anelloviruses: investigating its role in human diseases

Sabbaghian,

Gheitasi,

Shekarchi

et al. 2024

BMC Microbiol

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Anelloviruses (AVs) that infect the human population are members of the Anelloviridae family. They are widely distributed in human populations worldwide. Torque teno virus (TTV) was the first virus of this family to be identified and is estimated to be found in the serum of 80–90% of the human population. Sometime after the identification of TTV, Torque teno mini virus (TTMV) and Torque teno midi virus (TTMDV) were also identified and classified in this family. Since identifying these viruses, have been detected in various types of biological fluids of the human body, including blood and urine, as well as vital organs such as the liver and kidney. They can be transmitted from person to person through blood transfusions, fecal-oral contact, and possibly sexual intercourse. Recent studies on these newly introduced viruses show that although they are not directly related to human disease, they may be indirectly involved in initiating or exacerbating some human population-related diseases and viral infections. Among these diseases, we can mention various types of cancers, immune system diseases, viral infections, hepatitis, and AIDS. Also, they likely use the microRNAs (miRNAs) they encode to fulfill this cooperative role. Also, in recent years, the role of proliferation and their viral load, especially TTV, has been highlighted to indicate the immune system status of immunocompromised people or people who undergo organ transplants. Here, we review the possible role of these viruses in diseases that target humans and highlight them as important viruses that require further study. This review can provide new insights to researchers.

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Potential association of obesity with IL6 G-174C polymorphism and TTV infections

Cited by 5 publications

References 75 publications

Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies

Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies

The Molecular Epidemiology and Phylogeny of Torque Teno Virus (TTV) in Jordan

The mysterious anelloviruses: investigating its role in human diseases

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