Potential autophagy enhancers attenuate rotenone-induced toxicity in SH-SY5Y

Tris (1, 3-dichloro-2-propyl) phosphate induces apoptosis and autophagy in SH-SY5Y cells: Involvement of ROS-mediated AMPK/mTOR/ULK1 pathways

“…Some evidence has shown that 3-MA can enhance the effect of environmental neurotoxicants by triggering apoptosis in SH-SY5Y cells as it exacerbated the release of cytochrome C to the cytosol and then increased SH-SY5Y cell apoptosis induced by CFP (Park et al, 2013a). 3-MA has also been shown to aggravate cell apoptosis in fipronil-and rotenone-treated SH-SY5Y cells (Xiong et al, 2011;Park et al, 2013b). However, in the CQ-pretreated cells, the LC3II expression was markedly increased compared to that following TDCIPP treatment alone.…”

“…Several previous studies have shown that environmental toxicants, such as rotenone, CPF and triorthocresyl phosphate (TOCP), are neurotoxic and can affect nerve cell apoptosis by regulating autophagy in SH-SY5Y cells (Park et al, 2013a;Xiong et al, 2011;Long et al, 2014). These studies suggested that neurotoxic chemicals can induce both apoptosis and autophagy.…”

Autophagy and ethanol neurotoxicity

“…63,109 Lithium-induced autophagy seems to mediate its protective function in the neurodegeneration see in the PD model. 112,113 In fact, lithium alleviates ethanol-induced neuroapoptosis in cultured neurons and developing brain. 7,32,73 Although these drugs may be beneficial by activating autophagy in the brain, the potential teratogenic effects need to be carefully evaluated.…”

Exploring the Role of Autophagy in the Pathogenesis of Rotenone-induced Toxicity

“…In neuronal cells the neuroprotective mechanism of compounds such as iron chelators, flavonoids and terpenoids seems to be mediated by an autophagy induction [147][148][149][150][151]. Supporting this hypothesis, autophagy enhancers, such as rapamycin and lithium chloride, and potential autophagy enhancer, such as valproic acid and carbamazepine, have been demonstrated to significantly reduce rotenone-induced toxicity in vitro [152].…”