Potential benefit of biventricular pacing in patients with congestive heart failure and ventricular tachyarrhythmia

Stellbrink, Christoph; Auricchio, Angelo; Diem, B.; Breithardt, Ole A.; Kloss, Michael; Schöndube, Friedrich A.; Klein, Helmut U.; Messmer, Bruno J.; Hanrath, Peter

doi:10.1016/s0002-9149(98)01016-9

Cited by 114 publications

(73 citation statements)

References 63 publications

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“…In previous studies evaluating potential CRT candidates, the majority of patients had CHF as a result of ischemic heart disease and it remains unclear how many patients with idiopathic DCM can be candidates for CRT. [19][20][21] Our results showed that patients with a QRS duration = 120 ms are present in 39.2% of DCM, which is consistent with the findings of Girmm et al in DCM. 22 Dilated cardiomyopathy can be associated with a prolonged QRS duration =120 ms more frequently than CHF because of ischemia (20-25%).…”

Section: Discussionsupporting

confidence: 92%

“…Systolic function decreased as QRS duration increased, which is consistent with other studies, 19,[23][24][25] and there was a fair inverse correlation (r=-0.58, P<0.0001) between the QRS duration and the LVEF in patients with DCM. Normalizing the QRS duration by CRT is expected to improve hemodynamic performance as a result of synchronized contractions.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Potential Candidates for Cardiac Resynchronization Therapy in Japanese Patients With Idiopathic Dilated Cardiomyopathy-A Niigata Multicenter Study of DCM-

Komura¹,

Chinushi²,

Kudo

et al. 2004

Circ J

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Potential Candidates for Cardiac Resynchronization Therapy in Japanese Patients With Idiopathic Dilated Cardiomyopathy-A Niigata Multicenter Study of DCM-

Komura¹,

Chinushi²,

Kudo

et al. 2004

Circ J

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“…33 Similarly, QRSd correlated with NYHA class. 34,35 In more than 5000 outpatients with CHF, 32% of patients with complete left bundle branch block (LBBB) were in NYHA class III or IV as compared to 26% of patients with incomplete LBBB. 34 Another study showed that the incidence of QRSd >120 ms increased from 10% to 32% and 53% as NYHA class worsened from I to II and III, respectively.…”

Section: Comparison To Previous Registries and Reportsmentioning

confidence: 99%

QRS Duration Is Associated With Atrial Fibrillation in Patients With Left Ventricular Dysfunction

El‐Chami

Brancato²,

Langberg

et al. 2010

Clinical Cardiology

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Background: QRSduration (QRSd) is associated with higher mortality and morbidity in patients with left ventricular (LV) dysfunction. The association between QRSd and atrial fibrillation (AF) has not been studied in this patient population. Objectives: To investigate the association between QRSd and AF in patients with LV dysfunction. Methods: Data were obtained from the National Registry to Advance Heart Health (ADVANCENT) registry, a prospective multicenter registry of patients with left ventricular ejection fraction (LVEF) ≤40%. A total of 25 268 patients from 106 centers in the United States, were enrolled between June 2003 and November 2004. Demographic and clinical characteristics of patients were collected from interviews and medical records. Results: Mean age was 66.3 ± 13 years, 71.5% were males, and 81.9% were white. A total of 14 452 (57.8%) patients had a QRSd <120 ms, 5304 (21.2%) had a QRSd between 120 and 150 ms, and 5269 (21%) had a QRSd >150 ms. Atrial fibrillation occurred in 20.9%, 27.5%, and 35.5% of patients in the QRS groups, respectively (P < 0.0001). After adjusting for potential AF risk factors (age, gender, race, body mass index, hypertension, diabetes, renal failure, cancer, lung disease, New York Heart Association [NYHA] class, ejection fraction, etiology of cardiomyopathy) and the use of angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, β-blockers, and lipid lowering drugs, QRS duration remained independently associated with AF (odds ratio: 1.20, 95% confidence interval: 1.14-1.25). Conclusion:In this large cohort of patients, QRSd was strongly associated with AF and therefore may predict the occurrence of this arrhythmia in patients with LV dysfunction. This association persisted after adjusting for disease severity, comorbid conditions, and the use of medications known to be protective against AF.

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“…It is particularly important since some studies showed QRS duration increases as left ventricular function worsens (Iuliano et al, 2002;Stellbrink et al, 1999). Others (Freudenberger, Sikora, Fisher, Wilson, & Gold, 2004;Shamim et al, 1999;Silverman, 1995), demonstrated that patients with QRS prolongation have higher all-cause mortality and possibly a higher incidence of sudden death (or cardiac death) than those with narrow QRS complexes.…”

Section: Discussionmentioning

confidence: 99%

<b>Profile of the cardiac repolarization in cervical spinal cord injury subjects performing physical exercise

Magalhães

Martins

Maior

et al. 2017

Acta Sci. Health Sci.

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ABSTRACT. The aim of the study was to compare rest QT interval and QTcorrected intervals of electrocardiogram in trained men with and without cervical spinal cord injury (CSCI) and investigate cardiac electrocardiogram parameters in trained men with CSCI submitted to maximal effort test. Thirty men were separated into three groups: Control without CSCI (CON, 25.3 ± 4.1 yrs, strength training: 3 days week Perfil da repolarização cardíaca de sujeitos com lesão medular cervical submetidos a exercícios físicos RESUMO. O objetivo do presente estudo foi comparar o perfil dos intervalos QT e QT corrigido (QTc) em homens treinados com e sem lesão medular cervical (LMC) e investigar o perfil eletrocardiográfico de homens treinados com LMC submetidos ao teste de esforço máximo. Trinta homens foram separados em três grupos: controle sem LMC (CON, indivíduos fisicamente ativos; n = 10), LMC praticantes de alto volume de exercícios (praticantes de rugby em cadeira de rodas 180 min. Semana -1 ; n = 12) e LMC praticantes de moderado volume de exercícios (praticantes de rugby em cadeira de rodas 120 min. Semana -1 ; n = 8). Todos os participantes do grupo LMC apresentavam lesões incompletas (C5-C7) mais do que 12 meses. Eletrocardiograma foi registrado em repouso, durante e após o teste de esforço. O intervalo QT apresentou redução significativa (p = 0,001) no grupo de alto volume de exercícios quando comparado ao controle. O QTc não mostrou diferença entre os distintos volumes de exercícios (p > 0,05). Ambos os grupos LMC não apresentaram mudanças significativas no intervalo QT, QTc, intervalos PR e QRS entre o repouso e pós-esforço (p > 0,05). Concluimos que o alto volume de exercícios semanais parece promover anormalidades na repolarização cardíaca.Palavras-chave: lesão medular cervical, treinamento físico, eletrocardiograma, repolarização ventricular.

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Potential benefit of biventricular pacing in patients with congestive heart failure and ventricular tachyarrhythmia

Cited by 114 publications

References 63 publications

Potential Candidates for Cardiac Resynchronization Therapy in Japanese Patients With Idiopathic Dilated Cardiomyopathy-A Niigata Multicenter Study of DCM-

Potential Candidates for Cardiac Resynchronization Therapy in Japanese Patients With Idiopathic Dilated Cardiomyopathy-A Niigata Multicenter Study of DCM-

QRS Duration Is Associated With Atrial Fibrillation in Patients With Left Ventricular Dysfunction

<b>Profile of the cardiac repolarization in cervical spinal cord injury subjects performing physical exercise

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