Potential Benefits of Probiotics, Prebiotics, and Synbiotics on the Intestinal Microbiota of the Elderly

Bedani, Raquel; Saad, Susana Marta Isay; Sivieri, Kátia

doi:10.1016/b978-0-12-802189-7.00037-x

Cited by 9 publications

(9 citation statements)

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“…The major effects of synbiotics include increasing beneficial gut microbiota and balancing gut microbiota [ 21 , 22 , 23 , 27 , 28 ]. However, no information is available on their impact on the entire phylogenetic structure of the intestinal microbiota in aged people.…”

Section: Introductionmentioning

confidence: 99%

Association between Altered Blood Parameters and Gut Microbiota after Synbiotic Intake in Healthy, Elderly Korean Women

et al. 2020

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Synbiotics intake can alter the composition of intestinal microbes beneficially. We aimed to detect the changes in the intestinal microbiomes of 37 healthy elderly Korean women after the intake of a synbiotic drink. This was a longitudinal study controlled with a temporal series, including a control period of 3 weeks before intake, synbiotic intake for 3 weeks, and a washout period of 3 weeks. Fecal microbiota composition was analyzed by sequencing the V3-V4 hypervariable regions of 16S rRNA. Physical fecal activity increased with improvement in fecal shape. Thirty intestinal bacterial taxa were observed to change only after the intake period. In particular, Ellagibacter appeared only after ingestion. In addition, the abundance of Terrisporobacter showed a positive correlation with C-reactive protein, triglyceride. Lachnospiraceae_uc, Eubacterium_g5, and Blautia had a positive correlation with creatinine, whereas PAC001100_g had a negative correlation with creatinine. Short-term (3 weeks) intake of symbiotic organisms changes the composition of the gut microbiota in healthy elderly Korean women.

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Section: Introductionmentioning

confidence: 99%

Association between Altered Blood Parameters and Gut Microbiota after Synbiotic Intake in Healthy, Elderly Korean Women

et al. 2020

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“…Most bacteria in adults gut are nonsporing anaerobes, which include Firmicutes, Bacteroides spp., Bifidobacterium spp., Eubacterium spp., and other gram positive cocci. 8 There are 3 main functions of gut microbiota. First, microbiota as a protective agent.…”

Section: Microbiota In Gastrointestinal Tractmentioning

confidence: 99%

“…And the last is synbiotics, which are combined supplementation of probiotics and prebiotics. 8 Microbiota modulates the immune system in humans by stimulating the immune system either the nonspecific (innate) or the selective (adaptive), or both. Probiotics can also stimulate directly into the humoral or cellular immune system.…”

Section: Potential Benefits Of Probiotic Supplementation In the Elderlymentioning

confidence: 99%

The THE ROLE OF PROBIOTIC SUPPLEMENTATION ON THE IMMUNE SYSTEM IN ELDERLY

Shalim¹,

Yoewono²,

Utomo³

et al. 2019

IJMBS

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Elderly tends to be more susceptible to infections and chronic diseases. Malnutrition, immunosenescence, and changes in the gut microbiota affect susceptibility to the elderly. Several studies have shown that there is a change in the composition and variability of gut microbiota as we grow older. These changes are considered to increasing the risk of infection and play a role in the pathogenesis of various diseases in elderly. Supplementation of probiotics is expected to overcome the microbiota changes in the elderly and therefore improve the health of the elderly. In this review we will discuss about normal gut microbiota, changes in gut microbiota in the elderly, and effects of probiotics, prebiotics and synbiotics supplementation in the elderly. We will also review recent studies on the health benefits of probiotics for the elderly immune system as a new strategy for healthy aging. Recent data suggests that supplementation of probiotics can increase the immunity of the elderly. Further research is needed so that probiotic supplementation can be applied in clinical setting as a supporting therapy to improve the health of the elderly.

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“…Worldwide, elderly people (aged 65 or older) represent 12.4% of the global population ( Bedani et al, 2016 ). According to the European Union, the share of people aged 80 years or above is projected to have a two-and-a-half-fold increase between 2019 and 2100, from 5.8 to 14.6% (Eurostat Statistics Explained, 20201 1 ).…”

Section: Introductionmentioning

confidence: 99%

“…This rapid evolution has a significant impact on national public health institutes, social services, and health care systems. Consequently, elderly people are gaining increasing interest since they suffer from chronic health conditions that affect their quality of life, leading to a high demand of health services in general ( Bedani et al, 2016 ). For this reason, new options for preserving their health have been investigated, with being functional food a potential option.…”

Section: Introductionmentioning

confidence: 99%

Role of Probiotics, Prebiotics, and Synbiotics in the Elderly: Insights Into Their Applications

Ale

Binetti

2021

Front. Microbiol.

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Elderly people are an important part of the global population who suffer from the natural processes of senescence, which lead to changes in the gut microbiota composition. These modifications have a great impact on their quality of life, bringing a general putrefactive and inflammatory status as a consequence. Some of the most frequent conditions related to this status are constipation, undernutrition, neurodegenerative diseases, susceptibility to opportunistic pathogens, and metabolic disbalance, among others. For these reasons, there is an increasing interest in improving their quality of life by non-invasive treatments such as the consumption of probiotics, prebiotics, and synbiotics. The aim of the present mini-review is to describe the benefits of these functional supplements/food according to the most recent clinical and pre-clinical studies published during the last decade. In addition, insights into several aspects we consider relevant to improve the quality of future studies are provided.

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Potential Benefits of Probiotics, Prebiotics, and Synbiotics on the Intestinal Microbiota of the Elderly

Cited by 9 publications

References 99 publications

Association between Altered Blood Parameters and Gut Microbiota after Synbiotic Intake in Healthy, Elderly Korean Women

Association between Altered Blood Parameters and Gut Microbiota after Synbiotic Intake in Healthy, Elderly Korean Women

The THE ROLE OF PROBIOTIC SUPPLEMENTATION ON THE IMMUNE SYSTEM IN ELDERLY

Role of Probiotics, Prebiotics, and Synbiotics in the Elderly: Insights Into Their Applications

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