Potential bioactive phytochemicals, antioxidant properties and anticancer pathways of Nymphaea nouchali

Uddin, Nazim; Samad, Md. Abdus; Zubair, Muhammad; Haque, Md. Zahurul; Mitra, K.; Khan, Tanzir Ahmed; Hossain, Amir; Syed, Ashikujaman; Afroze, Aklima

doi:10.4103/2221-1691.297055

Cited by 12 publications

(11 citation statements)

References 4 publications

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“…These standard substances have been reported to have excellent antioxidant activity, which further indicated that NHEP has great potential as a natural antioxidant. Uddin et al identified 9 bioactive phytochemicals from methanolic extract of Nymphaea nouchali using an HPLC system [ 54 ]. Among these compounds, rutin (39.44 mg/g), myricetin (30.77 mg/g), ellagic acid (11.05 mg/g), gallic acid (5.33 mg/g) and quercetin (0.90 mg/g) were polyphenols or flavonoids, which were also identified as bioactive ingredients of NHEP in this work.…”

Section: Resultsmentioning

confidence: 99%

“…The powder of NHEP was prepared to the solution of 1 mg/mL. Chromatographic conditions [ 29 , 54 , 55 ]: C18 column (4.6 mm × 250 mm, 5 μm); mobile phase: 0.1% formic acid in water (A) and acetonitrile (B); gradient elution conditions were 5–13% B for 0–10 min, 13% B for 10–20 min, 13–20% B for 20–35 min, 20–45% B for 35–55 min, 45–100% B for 55–60 min; sample injection volume was 10 μL; flow rate: 1 mL/min; column temperature: 35 °C; detection wavelength: 280 nm.…”

Section: Methodsmentioning

confidence: 99%

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Optimization of Ultrasound-Assisted Cellulase Extraction from Nymphaea hybrid Flower and Biological Activities: Antioxidant Activity, Protective Effect against ROS Oxidative Damage in HaCaT Cells and Inhibition of Melanin Production in B16 Cells

et al. 2022

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In this study, ultrasonic-assisted cellulase extraction (UCE) was applied to extract flavonoids and polyphenols from the Nymphaea hybrid flower. The extraction conditions were optimized using the response surface method (RSM) coupled with a Box-Behnken design. The crude extract of Nymphaea hybrid (NHE) was further purified using AB-8 macroporous resins, and the purified extract (NHEP) was characterized by FTIR and HPLC. In vitro activity determination by chemical method showed that NHEP displayed strong free radical scavenging abilities against the DPPH and ABTS radicals, good reduction power, and hyaluronidase inhibition. The cell viability by CCK-8 assays showed that NHEP had no significant cytotoxicity for B16 and HaCaT cells when the concentration was below 100 μg/mL and 120 μg/mL, respectively. NHEP with a concentration of 20–160 μg/mL can more effectively reduce the ROS level in H2O2 damaged HaCaT cells compared with 10 μg/mL of VC. The 40 μg/mL of NHEP had similar activity against intracellular melanin production in the B16 melanoma cells compared with 20 μg/mL Kojic acid. Good activities of antioxidation, whitening and protective effect against H2O2-induced oxidative damage promote the potential for NHEP as a functional raw material in the field of cosmetics and medicine.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Optimization of Ultrasound-Assisted Cellulase Extraction from Nymphaea hybrid Flower and Biological Activities: Antioxidant Activity, Protective Effect against ROS Oxidative Damage in HaCaT Cells and Inhibition of Melanin Production in B16 Cells

et al. 2022

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“…Methanol extracts (ME) of four samples were prepared by dispersing them in 99.9% methanol. 1.0 g of each sample was dissolved in 10 ml methanol in a falcon tube with occasional shaking and stirring, finally sonication for 30 min [ 23 ]. This process was repeated five times to collect 50 ml of methanol extract from every specific sample (i.e., raw soy flour, full-fat soy flour, defatted soy flour, and soy protein concentrate).…”

Section: Methodsmentioning

confidence: 99%

Nutritional, Phytochemical, and In Vitro Antioxidant Activity Analysis of Different States of Soy Products

Robbani

Hossen

Mitra

et al. 2022

International Journal of Food Science

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Consumer demand for food nutritional content and quality is driving the design of plant-based foods that are enhanced with proteins. In this study, we aimed to reveal the nutrient compositional differences of various states of soy flours. We compared soy protein concentrate (SPC) with full fat (FF), raw soy flour (RSF), and defatted (DF) soy flour for investigating nutritional content, phytochemicals, and in vitro antioxidant activity. The results showed that the SPC contained significantly ( p < 0.001 ) higher protein content (65.14%) and low-fat content (0.54%) than RSF, FF, and DF. Furthermore, the findings revealed that all products contain a significant (ANOVA, p < 0.001 ) amount of essential minerals. The RSF contains significantly higher ( p < 0.001 ) potassium (1178.6 mg), calcium (216.77 mg), and magnesium (247 mg) per 100 g than FF, DF, and SPC. SPC contains essential amino acids, but we were unable to detect phenylalanine and tryptophan due to a limitation in the method. Furthermore, using methanolic and aqueous extracts of RSF, FF, DF, and SPC, the flavonoid, phenolics, and antioxidant capacity were also evaluated. According to the findings, soy products in methanolic extract had higher phenolic (about 12-34 mg/g) and flavonoid (about 63-150 mg/g) levels than aqueous extract. Results also demonstrated that FF had higher phenolic content, and SPC had higher flavonoid content than the other products. In vitro models such as phosphomolybdenum blue, FRAP, DPPH, and ABTS assays were used to study the total antioxidant and free radical scavenging potential of soy products, and results found that soy products contained a significant ( p < 0.001 ) amount of antioxidant equivalent to gallic acid and vitamin C standard. In the DPPH and ABTS assays, the results also showed that soy products can reduce free radicals in different in vitro models. Altogether, these findings suggest that soy flours, particularly DF and SPC, could be a beneficial food ingredient in the formulation of functional foods.

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“…It is widely distributed in South Asian countries, Australia, and Africa [ 115 ]. Plant extracts are reported to contain rutin, catechin, myricetin, ellagic acid, gallic acid, vanillic acid, rosmarinic acid, p-coumaric acid, quercetin, and ascorbic acid [ 116 , 117 ].…”

Section: Some Significant Aquatic and Semiaquatic Medicinal Plantsmentioning

confidence: 99%

“…For example, the edible part of Oryza sativa (rice) is its grain. In contrast, the leaves of Nasturtium officinale (Watercress), Neptunia oleracea (Water mimosa), and Oenanthe javanica (Japanese parsley) are used as human food [ 117 ]. Some previous studies revealed that Enhydra fluctuation , an edible semiaquatic herbaceous vegetable, is a rich source of phytochemicals such as β -carotene and ascorbic acid, which are required in diet supplements [ 172 ].…”

Section: Uses Of Aquatic and Semiaquatic Medicinal Plantsmentioning

confidence: 99%

Ethnomedicinal Use, Phytochemistry, and Other Potential Application of Aquatic and Semiaquatic Medicinal Plants

Arya

Durgapal

Bachheti

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Medicinal plants have been treating various ailments and diseases since ancient times. Aquatic and semiaquatic medicinal plants play an essential role in human welfare to fulfill their daily needs. They have shown biological, pharmacological, nutraceutical, and commercial applications. This review aims to collect and update all recent information on ethnomedicinal, phytochemistry, pharmacological activities, and nanoparticle synthesis and their uses in aquatic and semiaquatic medicinal plants. Original research papers, review papers, short communications, and book chapters on aquatic and semiaquatic plants have been retrieved from PubMed, Web of Science, Scopus, and Google Scholar. Keywords, ethnomedicinal studies, phytochemistry, pharmacological activities, and nanoparticle synthesis from aquatic and semiaquatic medicinal plants are used for the search. Different aquatic and semiaquatic medicinal plants belonging to the families Acanthaceae, Alismataceae, Amaranthaceae, Apiaceae, Araceae, Asteraceae, Boraginaceae, Ceratophyllaceae, Cyperaceae, Fabaceae, Hydrocharitaceae, Lythraceae, Marsileaceae, Menyanthaceae, Nelumbonaceae, Nymphaeaceae, Onagraceae, Plantaginaceae, Poaceae, Polygonaceae, Pontederiaceae, Primulaceae, Scrophulariaceae, and Zingiberaceae have been studied. They are rich in alkaloids, flavonoids, terpenoids, phenolics, saponins, tannins, dietary fiber, glycosidic derivatives, carbohydrates, and proteins. These phytochemicals have been used for their antimicrobial, antioxidant, hepatoprotective, sedative, anticonvulsant, cytotoxic, antiparasitic, and antidiabetic activities. Besides this, various parts of the plants are used as dietary supplements and green nanoparticle synthesis. These plants are also known for their commercial value and are used as an ingredient in some pharmaceutical industries.

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Potential bioactive phytochemicals, antioxidant properties and anticancer pathways of Nymphaea nouchali

Cited by 12 publications

References 4 publications

Optimization of Ultrasound-Assisted Cellulase Extraction from Nymphaea hybrid Flower and Biological Activities: Antioxidant Activity, Protective Effect against ROS Oxidative Damage in HaCaT Cells and Inhibition of Melanin Production in B16 Cells

Optimization of Ultrasound-Assisted Cellulase Extraction from Nymphaea hybrid Flower and Biological Activities: Antioxidant Activity, Protective Effect against ROS Oxidative Damage in HaCaT Cells and Inhibition of Melanin Production in B16 Cells

Nutritional, Phytochemical, and In Vitro Antioxidant Activity Analysis of Different States of Soy Products

Ethnomedicinal Use, Phytochemistry, and Other Potential Application of Aquatic and Semiaquatic Medicinal Plants

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