Potential bioactivity of Algerian olive pomace hydro-ethanolic extract: phytochemical investigation, antioxidant activity, and acute toxicity

Antioxidant and antidiabetic properties of olive pomace's hydro-ethanolic extract and aqueous fraction using an animal model of diabetes produced by streptozotocin (STZ)

“…The hydro-ethanolic extract of olive pomace demonstrates a favorable safety pro le in Wistar rats. No acute toxicity was observed after 14 days, even at the highest administered dose (LD 50 > 5000 mg/kg) [17]. This safety pro le, combined with the extract's potential antioxidant properties, suggests its suitability for long-term administration.…”

“…Toxicity assessment is a crucial step in developing any new compound. A previous study by [17] reported that olive extract showed no acute toxicity in Wistar rats, with an LD 50 exceeding 5000 mg/kg. Building on this nding, we investigated the longterm effects of olive extract on STZ-induced diabetic rats, focusing on its potential to alleviate oxidative stress and tissue damage in organs like the pancreas, kidneys, and liver.…”

“…The acute toxicity of the olive hydro-ethanolic extract was evaluated by [17] following OECD guidelines 425 [23].…”

“…The hydro-ethanolic extract of olive pomace contains phytoconstituents such as tannins, phenolic compounds, and avonoids, which possess potential antioxidant properties Prior research by [17]. Whereas the chemical composition of olive pomace, as evidenced by various studies including those by [28][29], comprises a range of compounds such as saponins, polyphenols, avonoids, tannins, quinones, terpenoids, hydroxytyrosol, tyrosol, oleuropein, caffeic acid, benzoic acid, rutin, vanillin, coumaric acid, and quercetin.…”