Potential biomarkers as an indicator of vertical transmission of Johne's disease in a Korean native cattle farm

Park, Hong-Tae; Park, Hyun-Eui; Cho, Yong-Il; Kim, Eui-Hyung; Jung, Myunghwan; Shin, Seung Won; Lee, Su-Hyung; Kim, Dae-Yong; Yoo, Han Sang

doi:10.4142/jvs.2017.18.s1.343

Cited by 7 publications

(5 citation statements)

References 36 publications

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“…The infection is most common in young animals through ingestion of contaminated colostrum and milk of infected dams. The organism can also be transmitted from an infected pregnant dam to its foetus through the placenta [ 36 ]. A non-infected herd generally becomes exposed through herd expansion or replacement purchases of carrier animals [ 37 ].…”

Section: Transmission Of Mapmentioning

confidence: 99%

Paratuberculosis: The Hidden Killer of Small Ruminants

Idris

Eltom

Okuni

et al. 2021

Animals

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Paratuberculosis (PTB) is a contagious and chronic enteric disease of ruminants and many non-ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP), and is characterised by diarrhoea and progressive emaciation with consequent serious economic losses due to death, early culling, and reduced productivity. In addition, indirect economic losses may arise from trade restrictions. Besides being a production limiting disease, PTB is a potential zoonosis; MAP has been isolated from Crohn’s disease patients and was associated with other human diseases, such as rheumatoid arthritis, Hashimoto’s thyroiditis, Type 1 diabetes, and multiple sclerosis. Paratuberculosis in sheep and goats may be globally distributed though information on the prevalence and economic impact in many developing countries seem to be scanty. Goats are more susceptible to infection than sheep and both species are likely to develop the clinical disease. Ingestion of feed and water contaminated with faeces of MAP-positive animals is the common route of infection, which then spreads horizontally and vertically. In African countries, PTB has been described as a “neglected disease”, and in small ruminants, which support the livelihood of people in rural areas and poor communities, the disease was rarely reported. Prevention and control of small ruminants’ PTB is difficult because diagnostic assays demonstrate poor sensitivity early in the disease process, in addition to the difficulties in identifying subclinically infected animals. Further studies are needed to provide more insight on molecular epidemiology, transmission, and impact on other animals or humans, socio-economic aspects, prevention and control of small ruminant PTB.

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Section: Transmission Of Mapmentioning

confidence: 99%

Paratuberculosis: The Hidden Killer of Small Ruminants

Idris

Eltom

Okuni

et al. 2021

Animals

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“…Vertical transmission of MAP involves the prenatal exposure of unborn calves by MAP-positive cows/heifers through transplacental infection (Park et al ., 2017; Garvey, 2020). The possibility that susceptibility to MAP infection is inheritable has been analyzed to be low to moderate, so it is likely that the prevalence of vertical transmission is in some way related to the prevalence of MAP within the herd (Park et al ., 2017). An issue inherent to analyses of vertical transmission is difficulty in differentiating vertical from horizontal transmission (Judge et al ., 2006; Park et al ., 2017; Mitchell et al ., 2019).…”

Section: Johne's Diseasementioning

confidence: 99%

Alternatives to antibiotics in veterinary medicine: considerations for the management of Johne's disease

O'Connell

Coffey

O’Mahony

2023

Anim. Health. Res. Rev.

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Antibiotic resistance has become a major health concern globally, with current predictions expecting deaths related to resistant infections to surpass those of cancer by 2050. Major efforts are being undertaken to develop derivative and novel alternatives to current antibiotic therapies in human medicine. What appears to be lacking however, are similar efforts into researching the application of those alternatives, such as (bacterio)phage therapy, in veterinary contexts. Agriculture is still undoubtedly the most prominent consumer of antibiotics, with up to 70% of annual antibiotic usage attributed to this sector, despite policies to reduce their use in food animals. This not only increases the risk of resistant infections spreading from farm to community but also the risk that animals may acquire species-specific infections that subvert treatment. While these diseases may not directly affect human welfare, they greatly affect the profit margin of industries reliant on livestock due to the cost of treatments and (more frequently) the losses associated with animal death. This means actively combatting animal infection not only benefits animal welfare but also global economies. In particular, targeting recurring or chronic conditions associated with certain livestock has the potential to greatly reduce financial losses. This can be achieved by developing novel diagnostics to quickly identify ill animals alongside the design of novel therapies. To explore this concept further, this review employs Johne's disease, a chronic gastroenteritis condition that affects ruminants, as a case study to exemplify the benefits of rapid diagnostics and effective treatment of chronic disease, with particular regard to the diagnostic and therapeutic potential of phage.

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“…Calves are infected through contact with contaminated dairy products, soil, manure, water, etc. ( Park et al, 2017 ; Hassan et al, 2020 ). MAP can also be transmitted through mammary secretions, in utero , and via semen ( Abbas et al, 2011 ; Sorge et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis

Yao

Wang

et al. 2022

Front. Microbiol.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the pathogen of Johne’s disease (paratuberculosis), which mainly causes chronic infectious granulomatous enteritis in ruminants and has brought huge economic losses to animal husbandry. As a specific intracellular pathogen, when MAP invades the body, it is internalized by macrophages where it is able to replicate by inhibition of the phagosome maturation, escaping the host immune system and surviving, which leads to the spread of the disease. More recent studies have shown that circRNA is involved in many pathological and physiological processes of the body as the molecular sponge of miRNA, the scaffold of RNA binding protein and having the characteristic of being able to translate into protein. In this study, the mRNA and circRNA expression profiles of MAP-infected bovine monocyte-macrophages and uninfected bovine cells were analyzed by high-throughput sequencing. A total of 618 differentially expressed mRNA were screened out, including 322 upregulated mRNA and 296 downregulated mRNA. In addition, the analysis of circRNA differential expression profile showed 39 differentially expressed genes including 12 upregulated and 27 downregulated genes. Moreover, differential genes belonging to cytokine activity, chemokine activity, inflammatory reaction, apoptosis, and other functional groups related to macrophage immune response were significantly enriched in Gene Ontology (GO). Multiple signal pathways including NF-κB, MAPK, Toll-like receptor, IL-17, JAK-STAT, and other signaling pathways related to activating macrophage immune response were significantly enriched in Kyoto Encyclopedia of Genes and Genomes (KEGG). In addition, RT-qPCR technology verified the accuracy of the mRNA sequencing results. In this study, we have obtained the transcriptome information of mRNA and circRNA of bovine monocyte-macrophage infected with MAP. These results will provide data support for the further study of mRNA–miRNA–circRNA network and immune escape mechanism of MAP and will enrich the knowledge of the molecular immune mechanisms of Johne’s disease as well.

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Potential biomarkers as an indicator of vertical transmission of Johne's disease in a Korean native cattle farm

Cited by 7 publications

References 36 publications

Paratuberculosis: The Hidden Killer of Small Ruminants

Paratuberculosis: The Hidden Killer of Small Ruminants

Alternatives to antibiotics in veterinary medicine: considerations for the management of Johne's disease

Analysis of mRNA and circRNA Expression Profiles of Bovine Monocyte-Derived Macrophages Infected With Mycobacterium avium subsp. paratuberculosis

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