Potential Biomedical Applications of Collagen Filaments derived from the Marine Demosponges Ircinia oros (Schmidt, 1864) and Sarcotragus foetidus (Schmidt, 1862)

Pozzolini, Marina; Tassara, Eleonora; Dodero, Andrea; Castellano, Maila; Vicini, Silvia; Ferrando, Sara; Aicardi, Stefano; Cavallo, Dario; Bertolino, Marco; Petrenko, Iaroslav; Ehrlich, Hermann; Giovine, Marco

doi:10.3390/md19100563

Cited by 15 publications

(14 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Collagen, the most abundant fibrous protein, is found within hard and soft tissues, such as connective tissue [126], skin [127][128][129], tendon [130], cornea [131], and cartilage [132][133][134][135], and is a crucial constituent of the ECM [136]. In this regard, collagen derived from the bovine [137], porcine [138], fish [139], marine sponge [140], shellfish [141], and jellyfish [142] is largely explored, so as to be utilized as a biocompatible material in various fields [143].…”

Section: Collagen-based Hydrogelsmentioning

confidence: 99%

Protein-Based Hydrogels: Promising Materials for Tissue Engineering

et al. 2022

View full text Add to dashboard Cite

The successful design of a hydrogel for tissue engineering requires a profound understanding of its constituents’ structural and molecular properties, as well as the proper selection of components. If the engineered processes are in line with the procedures that natural materials undergo to achieve the best network structure necessary for the formation of the hydrogel with desired properties, the failure rate of tissue engineering projects will be significantly reduced. In this review, we examine the behavior of proteins as an essential and effective component of hydrogels, and describe the factors that can enhance the protein-based hydrogels’ structure. Furthermore, we outline the fabrication route of protein-based hydrogels from protein microstructure and the selection of appropriate materials according to recent research to growth factors, crucial members of the protein family, and their delivery approaches. Finally, the unmet needs and current challenges in developing the ideal biomaterials for protein-based hydrogels are discussed, and emerging strategies in this area are highlighted.

show abstract

Section: Collagen-based Hydrogelsmentioning

confidence: 99%

Protein-Based Hydrogels: Promising Materials for Tissue Engineering

et al. 2022

View full text Add to dashboard Cite

show abstract

“…However, skin and bones from bovine or porcine wastes continues to be the primary source of proteins for regenerative medicine. Recently, the scientific community has shown a strong interest in the marine collagen isolated from fish and various marine invertebrates, including sponges, used in tissue engineering [121,122]. Collagen extracts from Chondrosia reniformis (Nardo, 1847) do not cause toxicity in mammalian cells, but positive effects on the proliferation of L929 fibroblasts, HaCat keratinocytes and RAW 264.7 macrophages.…”

Section: Other Miscellaneous Activitiesmentioning

confidence: 99%

“…So, these data suggested that extracts could be exploited for cosmetic or regenerative medicine purposes, facilitating cell migration or proliferation at the site of the wounded epidermal and dermal cells [121]. Pozzolini et al [122] isolated collagen filaments from the marine sponges Ircinia oros and Sarcotragus foetidus (Schimdt, 1862), collected in the Ligurian Sea, and tested them on HaCat keratinocytes and L929 fibroblasts. Additionally, in this study, the extracts were effective for wound-healing when compared with the positive controls hydrogen peroxide and quartz.…”

Section: Other Miscellaneous Activitiesmentioning

confidence: 99%

Marine Demospongiae: A Challenging Treasure of Bioactive Compounds

et al. 2022

Self Cite

View full text Add to dashboard Cite

In the last decades, it has been demonstrated that marine organisms are a substantial source of bioactive compounds with possible biotechnological applications. Marine sponges, in particular those belonging to the class of Demospongiae, have been considered among the most interesting invertebrates for their biotechnological potential. In this review, particular attention is devoted to natural compounds/extracts isolated from Demospongiae and their associated microorganisms with important biological activities for pharmacological applications such as antiviral, anticancer, antifouling, antimicrobial, antiplasmodial, antifungal and antioxidant. The data here presented show that this class of sponges is an exciting source of compounds, which are worth developing into new drugs, such as avarol, a hydroquinone isolated from the marine sponge Disidea avara, which is used as an antitumor, antimicrobial and antiviral drug.

show abstract

“…These issues demonstrate a need for an alternative source of collagen and biomaterials. Marinederived biomaterials including chitin and alginate have demonstrated the benefits of marine biomaterials [3,4], and more recently collagens from marine sources have attracted great interest as biomaterials due to their biocompatibility, high biodegradability, low immunogenicity and ease of extraction [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Suitability of Marine- and Porcine-Derived Collagen Type I Hydrogels for Bioprinting and Tissue Engineering Scaffolds

et al. 2022

View full text Add to dashboard Cite

Collagens from a wide array of animals have been explored for use in tissue engineering in an effort to replicate the native extracellular environment of the body. Marine-derived biomaterials offer promise over their conventional mammalian counterparts due to lower risk of disease transfer as well as being compatible with more religious and ethical groups within society. Here, collagen type I derived from a marine source (Macruronus novaezelandiae, Blue Grenadier) is compared with the more established porcine collagen type I and its potential in tissue engineering examined. Both collagens were methacrylated, to allow for UV crosslinking during extrusion 3D printing. The materials were shown to be highly cytocompatible with L929 fibroblasts. The mechanical properties of the marine-derived collagen were generally lower than those of the porcine-derived collagen; however, the Young’s modulus for both collagens was shown to be tunable over a wide range. The marine-derived collagen was seen to be a potential biomaterial in tissue engineering; however, this may be limited due to its lower thermal stability at which point it degrades to gelatin.

show abstract

Potential Biomedical Applications of Collagen Filaments derived from the Marine Demosponges Ircinia oros (Schmidt, 1864) and Sarcotragus foetidus (Schmidt, 1862)

Abstract: Article [...]

Cited by 15 publications

References 55 publications

Protein-Based Hydrogels: Promising Materials for Tissue Engineering

Protein-Based Hydrogels: Promising Materials for Tissue Engineering

Marine Demospongiae: A Challenging Treasure of Bioactive Compounds

Suitability of Marine- and Porcine-Derived Collagen Type I Hydrogels for Bioprinting and Tissue Engineering Scaffolds

Contact Info

Product

Resources

About