Potential Cardiovascular and Metabolic Beneficial Effects of ω-3 PUFA in Male Obesity Secondary Hypogonadism Syndrome

Noce, Annalisa; Marrone, Giulia; Daniele, Francesca Di; Lauro, Manuela Di; Zaitseva, Anna Pietroboni; Jones, Georgia Wilson; Lorenzo, Antonino De; Daniele, Nicola Di

doi:10.3390/nu12092519

Cited by 12 publications

(10 citation statements)

References 112 publications

(142 reference statements)

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“…The role of ω-3 on the gut microbiota would seem to modulate the inflammatory response which lies at the base of several chronic non-communicable degenerative diseases (CNCDDs), such as atherosclerosis, cancer, neurodegenerative diseases, chronic renal failure, diabetes mellitus, male obesity secondary hypogonadism etc. [ 63 , 64 , 65 , 66 ]. Moreover, several studies speculate that the microbiota-PUFA ω-3 interaction is capable of modulating the immune system and inflammatory status [ 60 , 67 ].…”

Section: Mediterranean Diet and Microbiota Compositionmentioning

confidence: 99%

Influence of Mediterranean Diet on Human Gut Microbiota

et al. 2020

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Gut microbiota changes correlate with health status. Literature data on gut microbiota show that all dietary changes can induce the alteration of gut microbiota composition. Mediterranean diet (MD) is associated with a reduction of all-cause mortality and in this review, we analyzed its interactions with human microbiota. In particular, we explored the modulation of the human microbiota, in response to MD adherence, focusing the attention on polyphenols, polyunsaturated fatty acids (PUFA) ω-3 and fiber. Evidences suggest that MD is able to modulate the gut microbiota, increasing its diversity. In fact, a Mediterranean-type dietary pattern is associated with specific gut microbiota characteristics. The available evidence, suggests that gut microbiota of subjects that follow a MD is significantly different from subjects that follow a Western diet model. In fact, the latter show an increased gut permeability, which is responsible for metabolic endotoxemia. For this reason, we can speculate that the gut microbiota of the subjects following a MD is able to prevent the onset of chronic non-communicable degenerative diseases, such as cardiovascular diseases and some types of cancer. However, in order to understand these correlations with dietary patterns, controlled intervention studies on the gut microbiota composition and activity are needed.

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Section: Mediterranean Diet and Microbiota Compositionmentioning

confidence: 99%

Influence of Mediterranean Diet on Human Gut Microbiota

et al. 2020

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“…In fact, PBDs are generally rich in linoleic acid (e.g., flaxseed/linseed oils, chia seeds, flaxseed raw) that is able to reduce the conversion of α-linolenic acid (ALA) to EPA and DHA [ 77 , 78 ]. Other authors speculate that in vegans the mean ALA intake is at, or close, to an adequate intake (AI), namely 1.1 g/day in females and 1.6 g/day in males [ 77 , 79 , 80 ]. Therefore, the vegan diet, characterized by a low intake of ω-3 fatty acids, should be supported by oral food supplements such as microalgae supplements containing DHA, as well as by a regular consumption of foods with high ALA content in order to guarantee an optimal intake of these fatty acids.…”

Section: Plant-based Dietary Patterns and Environmental Impactsmentioning

confidence: 99%

“…Therefore, to obtain the best beneficial effect on lipid metabolism, it is necessary to replace SFAs with unsaturated fats. The intake of PUFA as very long chain ω-3 (EPA and DHA) in vegan diet is allowed by fish oil intake (if necessary, also as oral food supplement) and it has no substantial effect on LDL-C, while affecting the concentrations of TG, that are lower in a dose-dependent manner [ 80 , 113 , 176 ]. For this reason, a PBD for HDL-C control seems to be more effective.…”

Section: Metabolic Syndromementioning

confidence: 99%

Vegan Diet Health Benefits in Metabolic Syndrome

et al. 2021

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Plant-based diets (PBDs) are increasingly consumed by the Italian population and around the world. In particular, among PBDs, the vegan diet is a food pattern characterized by the exclusion of all animal-origin foods. What drives people to adopt this model are mainly ethical, health and environmental reasons. A vegan diet, if well-balanced and varied, can help in achieving and maintaining an optimal state of health. However, this nutritional approach, if not well-balanced, can cause deficiencies in proteins, ω-3 fatty acids, iron, vitamin D and calcium, zinc, iodine and, above all, vitamin B12. Oral food supplements especially fortified foods are recommended in these cases to restore the nutritional deficiencies. A vegan diet generally reduces the risk of developing chronic non-communicable degenerative diseases, such as metabolic syndrome (MetS) and, in addition, requires fewer natural resources for food production than an omnivorous diet. The aim of this review is to analyze the possible impact of the vegan diet on MetS onset and its treatment.

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“…Ω-3 polyunsaturated fatty acids (PUFAs) are known for their multiple protective effects against CV and inflammatory diseases [ 138 ]. Smith et al [ 139 ] conducted a study on 16 elderly patients without a noteworthy pathology subdividing them into two subgroups (group 1 and group 2).…”

Section: Other Special Types Of Nutritional Supplementsmentioning

confidence: 99%

Uremic Sarcopenia and Its Possible Nutritional Approach

et al. 2021

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Uremic sarcopenia is a frequent condition present in chronic kidney disease (CKD) patients and is characterized by reduced muscle mass, muscle strength and physical performance. Uremic sarcopenia is related to an increased risk of hospitalization and all-causes mortality. This pathological condition is caused not only by advanced age but also by others factors typical of CKD patients such as metabolic acidosis, hemodialysis therapy, low-grade inflammatory status and inadequate protein-energy intake. Currently, treatments available to ameliorate uremic sarcopenia include nutritional therapy (oral nutritional supplement, inter/intradialytic parenteral nutrition, enteral nutrition, high protein and fiber diet and percutaneous endoscopic gastrectomy) and a personalized program of physical activity. The aim of this review is to analyze the possible benefits induced by nutritional therapy alone or in combination with a personalized program of physical activity, on onset and/or progression of uremic sarcopenia.

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Potential Cardiovascular and Metabolic Beneficial Effects of ω-3 PUFA in Male Obesity Secondary Hypogonadism Syndrome

Cited by 12 publications

References 112 publications

Influence of Mediterranean Diet on Human Gut Microbiota

Influence of Mediterranean Diet on Human Gut Microbiota

Vegan Diet Health Benefits in Metabolic Syndrome

Uremic Sarcopenia and Its Possible Nutritional Approach

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