Potential causes of subfertility in patients with intramural fibroids

Pier, Bruce; Bates, G. Wright

doi:10.1186/s40738-015-0005-2

Cited by 15 publications

(17 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, uterosalpingography, and more recently cine-MRI, have shown that in infertile women, instead of normal cervix-to-fundal peristalsis at ovulation, the waves are reversed or irregular, thereby preventing sperm from fertilising the egg. Moreover, it is believed that the presence of fibroids is also a key factor in disrupting uterine peristalsis ( Pier and Bates, 2015 ). Furthermore, in some species, producing multiple embryos, regular, standing peristaltic waves may be responsible for spacing of the embryos within the uterus.…”

Section: Physiology Is More Than Molecules Eg Uterine Peristalsismentioning

confidence: 99%

The Physiology of Reproduction – Quo vadis?

Ivell

Anand‐Ivell

2021

Front. Physiol.

View full text Add to dashboard Cite

The reproductive system in males and females reflects a highly dynamic underlying physiology. Yet our current understanding of this system is still largely based upon relatively simplistic snapshots of individual component cells and tissues. Gamete production as well as gonadal hormone synthesis and its influence are the manifestations of dynamic and redundant informational networks and processes, whose qualitative and quantitative dimensions, especially through development from embryo through puberty and adulthood into ageing, are still largely uncharted. Whilst the recent huge advances in molecular science have helped to describe the components of the reproductive system in ever greater detail, how these interact and function in space and time dimensions is still largely obscure. Recent developments in microfluidics, stem cell biology, and the integration of single-cell transcriptomics with tissue dynamics are offering possible methodological solutions to this issue. Such knowledge is essential if we are to understand not only the normal healthy functioning of this system, but also how and why it is affected in disease or by external impacts such as those from environmental endocrine disruptors, or in ageing. Moreover, operating within a complex network of other physiological systems, its integrational capacity is much more than the generation of male and female gametes and their roles in fertility and infertility; rather, it represents the underpinning support for health and well-being across the lifespan, through pregnancy, puberty, and adulthood, into old age.

show abstract

Section: Physiology Is More Than Molecules Eg Uterine Peristalsismentioning

confidence: 99%

The Physiology of Reproduction – Quo vadis?

Ivell

Anand‐Ivell

2021

Front. Physiol.

View full text Add to dashboard Cite

show abstract

“…Computer simulations revealed that asymmetric contractions between the anterior and posterior walls of the uterus may lead to infertility due to transport of the blastocyst to a nonfundal site of implantation or prohibition of contact between the blastocyst and the endometrium during the window of implantation . Recent studies reported direct link between abnormal uterine peristalsis due to uterine fibroids and decreased pregnancy rate …”

Section: Uterine Disease Development and Infertilitymentioning

confidence: 99%

Biomechanics of the human uterus

Myers

Elad

2017

WIREs Mechanisms of Disease

View full text Add to dashboard Cite

The appropriate biomechanical function of the uterus is required for the execution of human reproduction. These functions range from aiding the transport of the embryo to the implantation site, to remodeling its tissue walls to host the placenta, to protecting the fetus during gestation, to contracting forcefully for a safe parturition and postpartum, to remodeling back to its nonpregnant condition to renew the cycle of menstruation. To serve these remarkably diverse functions, the uterus is optimally geared with evolving and contractile muscle and tissue layers that are cued by chemical, hormonal, electrical, and mechanical signals. The relationship between these highly active biological signaling mechanisms and uterine biomechanical function is not completely understood for normal reproductive processes and pathological conditions such as adenomyosis, endometriosis, infertility and preterm labor. Animal studies have illuminated the rich structural function of the uterus, particularly in pregnancy. In humans, medical imaging techniques in ultrasound and magnetic resonance have been combined with computational engineering techniques to characterize the uterus in vivo, and advanced experimental techniques have explored uterine function using ex vivo tissue samples. The collective evidence presented in this review gives an overall perspective on uterine biomechanics related to both its nonpregnant and pregnant function, highlighting open research topics in the field. Additionally, uterine disease and infertility are discussed in the context of tissue injury and repair processes and the role of computational modeling in uncovering etiologies of disease. WIREs Syst Biol Med 2017, 9:e1388. doi: 10.1002/wsbm.1388 For further resources related to this article, please visit the WIREs website.

show abstract

“…2 Recently, data are beginning to accrue suggesting adverse effect of fibroids on implantation by alteration of molecular markers of endometrial receptivity. [3][4][5] While reports available in literature are suggestive of definite detrimental effect of submucosal fibroids on endometrial receptivity, only a few reports are available which have demonstrated a negative impact of noncavity-distorting intramural fibroids on molecular mediators of endometrial receptivity. 5,6 Favorable impact of intramural myomectomy on receptivity markers and pregnancy outcome has recently been reported.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Akt Activation During Implantation Window in Infertile Women With Intramural Uterine Fibroids

et al. 2017

View full text Add to dashboard Cite

The objective of the study was to examine the expression and cellular distribution of key signaling components of the phosphatidylinositol-3-kinase (PI3K)/Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Protein Kinase B (PKB/Akt) pathway during the window of implantation in infertile women with noncavity-distorting intramural uterine fibroids (n = 21) as compared to fertile controls (n = 15). Relative gene expression analysis of PIK3CA, PTEN, Akt1, and Akt2 genes in midluteal endometrial biopsies was performed by real-time polymerase chain reaction. Immunohistochemistry was used to evaluate the expression of PIK3CA, PTEN, phospho-PTEN, Akt1, Akt2, phospho-Akt1 (serine 473), phospho-Akt1 (threonine 308), and Ki67 proteins. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling assay was performed for apoptosis detection. In comparison to fertile controls, significant upregulation of Akt1 messenger RNA levels (2.16-fold; P < .05); cell-specific upregulation of the proteins phospho-PTEN ( P < .05), Akt1 ( P < .05), Akt2 ( P < .05), and p-Akt (S473; P < .001); and downregulation of PTEN ( P < .01) were observed in endometrium of infertile women with intramural fibroids. The ratio of p-PTEN/PTEN and p-Akt1 (S473)/Akt1 was also significantly higher in infertile women. Increased Ki67 labeling index in the glandular epithelium and significantly lower apoptotic index in glandular epithelium and stroma were seen in infertile women during the window of implantation. Aberrant Akt activation and the associated imbalance in endometrial proliferation and apoptosis observed in infertile women with intramural fibroids during the midsecretory phase might contribute to impaired endometrial receptivity leading to infertility in these patients.

show abstract

Potential causes of subfertility in patients with intramural fibroids

Cited by 15 publications

References 62 publications

The Physiology of Reproduction – Quo vadis?

The Physiology of Reproduction – Quo vadis?

Biomechanics of the human uterus

Aberrant Akt Activation During Implantation Window in Infertile Women With Intramural Uterine Fibroids

Contact Info

Product

Resources

About