Potential chemoprotective role of resveratrol against cisplatin induced testicular damage in mice

Singh, Inderjeet; Goyal, Yasmeen; Ranawat, Pavitra

doi:10.1016/j.cbi.2017.05.024

Cited by 26 publications

(17 citation statements)

References 62 publications

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“…Enzyme activities of transaminases (GOT and GPT) procured from liver homogenate were significantly escalated with the administration of cisplatin at dose 2 for 7 days, clearly insinuating towards cisplatin-induced hepatotoxicity. Similar observations have been recorded by other scientists (Cao, 2018;Singh, 2017;Cagin, 2015).…”

Section: Discussionsupporting

confidence: 91%

Preventive effect of Curcumin against Cisplatin-related hepatotoxicity in Swiss Albino mice (Mus musculus L.)

Saha¹,

Pal²,

Goswami³

2018

JCHPS

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Chemotherapy is a type of cancer treatment that kills rapidly proliferating cells. Being a non-specific mode of treatment, it can cause damage to healthy cells like bone marrow cells, epithelial cells, hair follicles etc., resulting in various side effects. Cisplatin, a platinum coordination complex, is a common chemotherapeutic drug that is used in the treatment of several types of cancers, including testicular, ovarian and bladder cancer. Cisplatin interferes with DNA replication by forming cross-linking of DNA in the form of 1, 2-intrastrand crosslinks with purine bases. It can also cause missense mutations and breaks in DNA. The DNA injury triggers cell death and inhibits RNA and protein synthesis, especially in rapidly dividing cells. However, it has been observed to have profound participation in neuropathy, ototoxicity and nephrotoxicity, few among many other side effects. Changes in the activity of certain serum enzymes have been implicated to cisplatin-induced hepatotoxicity. In this study, we investigated the effect of cisplatin on Swiss Albino mice (Mus musculus L.) animal model. Mice were intraperitoneally administered with cisplatin at varying sublethal doses and exposure periods. They were tested for hepatotoxicity by estimating several biochemical parameters. The mid-toxic dose was co-treated with curcumin supplementation since curcumin has prominent anti-radical, anti-inflammatory and anti-mutagenic activities. The investigation was further extended to study the effect of cisplatin on hepatic cell viability and inspect presence of chromosomal aberrations. The present study shall assist in better comprehension of cisplatin-induced hepatotoxicity and effects of curcumin to prevent related side effects.

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Section: Discussionsupporting

confidence: 91%

Preventive effect of Curcumin against Cisplatin-related hepatotoxicity in Swiss Albino mice (Mus musculus L.)

Saha¹,

Pal²,

Goswami³

2018

JCHPS

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“…In agreement with these data, we have observed an increase in the level of MDA, a product of lipid peroxidation of acids polyunsaturated fat, an increase in the level of carbonylated proteins which is the consequence of the oxidation of proteins. Membrane lipid peroxidation at the level of testicular has also been demonstrated in other studies [16,17]. Rats were on a daily basis administered with 10% ethanol (C), GSSE, U.rigida, Cisplatin (Cis), U.rigida plus Cisplatin (Cis/U.rigida), or Cisplatin plus GSSE (Cis/GSSE) for 7 days and we determined levels of testis free iron ( Fig.…”

Section: Effect Of Treatments On Body Weightsupporting

confidence: 52%

The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats

Ksouri

Rabah

Mezghani³

et al. 2020

Sakarya University Journal of Science

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Cisplatin, an anticancer drug used in chemotherapy, has made considerable progress recently; particularly in the treatment of testicular cancer. However, the side effects of this treatment, limit its use. Grape Seed and Skin Extract (GSSE) and Ulva rigida (U. rigida) marine seaweeds are giving compounds with high antioxidant capacity. This work aims to develop a model in vivo to evaluate the protective effect of extracts of GSSE or U. rigida against the oxidative stress induced by cisplatin. This stress occurring in healthy cells is one of the major causes of the adverse effects of chemotherapy. Healthy male rats received an intraperitoneal injection of cisplatin only or cisplatin and GSSE or U. rigida extract. At the end of the treatment, the rats were sacrificed and from the crushed testicles; the supernatant was recovered for biochemical assays. The data showed that the dose of cisplatin induces testicular toxicity, and a pro-oxidant state characterized by increased levels of malondialdehyde, carbonyl proteins, superoxide anion, calcium and iron. Besides, treatment with cisplatin increases the activity of superoxide dismutase and inhibits the activity of catalase. GSSE or U. rigida extract exerts a protective effect on the testes of cisplatin-treated rats, or they protect against the adverse effects of oxidative stress induced by cisplatin to restore levels near control. This study demonstrated that GSSE and U. rigida can protect against cisplatin-induced cytotoxicity.

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“…Treatment with resveratrol in Groups II and IV started 48 h before starting the experiment and treatment in all Groups continued for further 4 successive weeks. The doses of resveratrol [21,22] and cisplatin [23][24][25] were selected as per previously published. Protein content were specified using protein assay kit.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Cisplatin induced testicular damage through mitochondria mediated apoptosis, inflammation and oxidative stress in rats: impact of resveratrol

Aly

Eid

2020

Endocr J

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The target of this study was to explore the role of mitochondria mediated apoptosis and inflammation in cisplatininduced testicular damage and to evaluate the ameliorative effect of resveratrol. Adult male Wistar rats were randomly allocated to 4 groups. Group I (Control) received normal saline, Group II (Resveratrol) received resveratrol (50 mg/kg/day), Group III (Cisplatin) received cisplatin (7.5 mg/kg/week, i.p.) and Group IV (Resveratrol + Cisplatin) received resveratrol and cisplatin in the same regimen of treatment. Treatment with resveratrol in Groups II and IV started 48h before cisplatin injection and continued for further 4 successive weeks. Cisplatin-treated rats showed reduced body weight, absolute testes weight and sperm count, motility and viability. On the other hand, cisplatin treatment increased the percentage of sperm abnormalities. It also decreased serum testosterone level, mitochondrial membrane potential while, increased cytochrome C liberation from the mitochondria into the cytosol. The activities of caspase-3 &-9 were increased. The level of TNF-α, IL-6 and Bax were increased whereas Bcl-2 was decreased. Oxidative stress markers were found to increase with a concomitant reduction in the antioxidant enzymes and GSH levels. These results were confirmed by immunohistochemical and histopathological analysis. Contrary to all these results, there were improvements in cisplatin induced testicular damage through attenuation of mitochondria mediated apoptosis, inflammation, and oxidative stress owing to resveratrol pretreatment. Thus, resveratrol, as a potential therapeutic agent, may hold promise in preventing mitochondria mediated apoptosis and inflammation in cisplatin-induced testicular damage in rats.

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Potential chemoprotective role of resveratrol against cisplatin induced testicular damage in mice

Cited by 26 publications

References 62 publications

Preventive effect of Curcumin against Cisplatin-related hepatotoxicity in Swiss Albino mice (Mus musculus L.)

Preventive effect of Curcumin against Cisplatin-related hepatotoxicity in Swiss Albino mice (Mus musculus L.)

The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats

Cisplatin induced testicular damage through mitochondria mediated apoptosis, inflammation and oxidative stress in rats: impact of resveratrol

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