Potential Clinical Value of Biomarker-Guided Emergency Triage for Thoracic Aortic Dissection

Qiu, Peng; Yang, Meng; Pu, Hui; Hou, Jingli; Chen, Xu; Wu, Zhaoyu; Huang, Qun; Huang, Siyi; Fu, Yan; Wen, Zi'ang; Zhang, Chengxin; Zha, Binshan; Yang, Yang; Xu, Zhijue; Chen, Fuxiang; Lu, Xinwu

doi:10.3389/fcvm.2021.777327

Cited by 6 publications

(1 citation statement)

References 65 publications

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“…Differential protein studies of thoracic aortic dissection and normal aortic tissue showed high expression of MIF. 22 Similar results were seen in abdominal aortic aneurysm specimens, the expression of MIF and MMPs was enhanced in ruptured abdominal aortic aneurysm specimens compared to stable abdominal aortic aneurysm and normal aortic specimens. 23 These results suggest the possibility of MIF as a biomarker for the identification of AD and assessment of prognosis.…”

Section: Introductionsupporting

confidence: 74%

MIF Regulates M1 Macrophage Polarization via CD74/CXCR2/JNK Pathway and Mediates Aortic Dissection in Mice

Wang,

et al. 2023

Preprint

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Background: Macrophage polarization and VSMC phenotypic switch are important features and critical targets in the progression of Aortic dissection (AD). High expression of MIF in aortic and blood specimens has been observed in patients with AD, but its precise function and mechanism in AD are unknown. We aimed to clarify whether MIF mediates the development of aortic dissection via modulation of M1 macrophage polarization. Methods: Based on the BAPN/Ang II-induced acute aortic dissection model and by intraperitoneal injection of the MIF antagonist ISO-1 to inhibit MIF activity in mice. We assayed macrophage infiltration, polarization, and VSMC phenotypic switching in the aorta of mice in each group. Further, we evaluated the polarizing effects of MIF on RAW264.7 cells directly or indirectly in vitro experiments and explored the specific cellular signaling pathways that mediate its function. At last, we evaluated the role and possible mechanisms of RAW264.7 cells with different degrees of polarization in inducing phenotypic switching of MOVAS cells based on a model of indirect co-culture. Results: Pharmacological inhibition of MIF decreased the incidence of aortic dissection and attenuated aortic vascular remodeling in mice by reducing M1 macrophage infiltration in aorta. In addition, we demonstrated that MIF could activate the intracellular JNK/c-Jun signaling pathway by targeting the CD74/CXCR2 receptor, promote M1 polarization and upregulate the expression of the M1 macrophage markers, iNOS, IL-18, and CD86 in RAW264.7 cells. Further experiments confirmed that upon co-culture with MIF-induced M1 macrophages, the NF-?B pathway was activated in MOVAS cells, inducing the onset of phenotypic switch and apoptosis. Conclusions: The results indicated that MIF mediated macrophage polarization and regulated the progression of aortic dissection, which provided new scientific evidence for the pathogenesis of aortic dissection, and also suggested that MIF may be a potential preventive and therapeutic target for aortic dissection and aortic-related diseases.

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Section: Introductionsupporting

confidence: 74%

MIF Regulates M1 Macrophage Polarization via CD74/CXCR2/JNK Pathway and Mediates Aortic Dissection in Mice

Wang,

et al. 2023

Preprint

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Anti-inflammatory response-based risk assessment in acute type A aortic dissection: A national multicenter cohort study

Liu,

Sun,

Tang

et al. 2024

IJC Heart & Vasculature

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Association of aortic dissection and lipoprotein (a): a meta-analysis

Motawea

Elhalag

Rouzan

et al. 2023

Annals of Medicine &Amp; Surgery

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Background and Aim: Some studies reported a positive relation between aortic dissection (AD) and increased lipoprotein (a) (LP(a)), while other studies reported no association, so the authors aimed to do a meta-analysis to establish the relation between AD and high levels of LP(a). Methods: PubMed, Scopus, Web of Science, SAGE, EMBASE, Science Direct, and Cochrane Library were searched. The inclusion criteria were any randomized control trials or observational studies that measured the levels of LP(a) in AD patients and healthy controls. The authors excluded case reports, case series, noncontrolled studies, reviews, editorials, and animal studies. Results: After a search of the literature, four studies were included in the meta-analysis with 678 patients included in the analysis. The pooled analysis showed a statistically significant association between the AD group and increased levels of LP(a), decreased levels of TG, low-density lipoprotein cholesterol, and TC compared with the control group (MD=11.71, 95% CI=4.11–19.32, P-value=0.003), (MD=−0,32, 95% CI=−0.48 to −0.16, P-value<0.0001 ), (MD=−0,21, 95% CI=−0.42 to −0.1, P-value=0.04), (MD=−0,58, 95% CI=−0.62 to −0.54, P-value<0.00001), respectively. Conclusion: Our study showed that AD is significantly associated with increased levels of LP(a). The significant increase in LP(a) in AD was associated with decreased levels of TG, low-density lipoprotein cholesterol, and TC. Future clinical trials testing Lp (a) targeting medications could be useful in the primary, or secondary prevention of AD in high risk patients.

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Potential Clinical Value of Biomarker-Guided Emergency Triage for Thoracic Aortic Dissection

Cited by 6 publications

References 65 publications

MIF Regulates M1 Macrophage Polarization via CD74/CXCR2/JNK Pathway and Mediates Aortic Dissection in Mice

MIF Regulates M1 Macrophage Polarization via CD74/CXCR2/JNK Pathway and Mediates Aortic Dissection in Mice

Anti-inflammatory response-based risk assessment in acute type A aortic dissection: A national multicenter cohort study

Association of aortic dissection and lipoprotein (a): a meta-analysis

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