“…We afforded the dual effect of NF-κB activation in preconditioning and lethal ischemia using neuronal cells exposed to oxygen glucose deprivation (OGD) and mice subjected to middle cerebral artery occlusion (MCAO) (Lanzillotta et al, 2010;Pizzi et al, 2009). After exposure to lethal ischemia, neuronal nuclei displayed a high level of p50/RelA activation (Crack et al, 2006;Inta et al, 2006) and decreased level of c-Relcontaining dimers (Sarnico et al, 2009a(Sarnico et al, , 2009b. Accordingly, mice deficient in p50 or RelA, but not mice deficient in c-Rel subunit, showed a reduced infarct size when exposed to MCAO (Inta et al, 2006;Schneider et al, 1999).…”