Potential Correlation between Dietary Fiber-Suppressed Microbial Conversion of Choline to Trimethylamine and Formation of Methylglyoxal

Li, Qian; Chen, Hạixia; Zhang, Min; Liu, Rui; Zhang, Zesheng

doi:10.1021/acs.jafc.9b04860

Cited by 15 publications

(10 citation statements)

References 57 publications

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“…Consistent with this, a recent study investigated concentrations of fecal and serum BAs in vegans and omnivores, showing a vegan diet low in fat and high in fiber was positively correlated with fecal BA concentrations (118). Additionally, Li et al have suggested that supplying the DF diet to mice can reduce TMA and TMAO outputs via inhibiting intestinal microbial TMA lyase activity (119). Thus, DF intervention for individuals with various clinical statuses is expected to become an emerging treatment against CRC.…”

Section: Diet Modulationmentioning

confidence: 79%

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Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges

Zhang

Qin

et al. 2021

Front. Oncol.

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Accumulating evidence from studies in humans and animal models has elucidated that gut microbiota, acting as a complex ecosystem, contributes critically to colorectal cancer (CRC). The potential mechanisms often reported emphasize the vital role of carcinogenic activities of specific pathogens, but in fact, a series of metabolites produced from exogenous dietary substrates or endogenous host compounds occupy a decisive position similarly. Detrimental gut microbiota-derived metabolites such as trimethylamine-N-oxide, secondary bile acids, hydrogen sulfide and N-nitroso compounds could reconstruct the ecological composition and metabolic activity of intestinal microorganisms and formulate a microenvironment that opens susceptibility to carcinogenic stimuli. They are implicated in the occurrence, progression and metastasis of CRC through different mechanisms, including inducing inflammation and DNA damage, activating tumorigenic signaling pathways and regulating tumor immunity. In this review, we mainly summarized the intimate relationship between detrimental gut microbiota-derived metabolites and CRC, and updated the current knowledge about detrimental metabolites in CRC pathogenesis. Then, multiple interventions targeting these metabolites for CRC management were critically reviewed, including diet modulation, probiotics/prebiotics, fecal microbiota transplantation, as well as more precise measures such as engineered bacteria, phage therapy and chemopreventive drugs. A better understanding of the interplay between detrimental microbial metabolites and CRC would hold great promise against CRC.

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Section: Diet Modulationmentioning

confidence: 79%

“…Additionally, Li et al. have suggested that supplying the DF diet to mice can reduce TMA and TMAO outputs via inhibiting intestinal microbial TMA lyase activity ( 119 ). Thus, DF intervention for individuals with various clinical statuses is expected to become an emerging treatment against CRC.…”

Section: Diet Modulationmentioning

confidence: 99%

Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges

Zhang

Qin

et al. 2021

Front. Oncol.

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“…The superpathway “methylglyoxal degradation IV” has a low coverage in subjects MH0001 and MH0004 ( Figure 6 ). Methylglyoxal is a product of glucose and glycine metabolism that increases the activity of the gut microbial trimethylamine (TMA)-lyase [ 46 ]. TMA lyase catalyzes the transformation of dietary choline and carnitine to TMA, which in turn is metabolized by the liver to trimethylamine-N-oxide (TMAO), a potential risk factor for cardiovascular diseases [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

In Silico Comparison Shows that the Pan-Genome of a Dairy-Related Bacterial Culture Collection Covers Most Reactions Annotated to Human Microbiomes

et al. 2020

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The diversity of the human microbiome is positively associated with human health. However, this diversity is endangered by Westernized dietary patterns that are characterized by a decreased nutrient variety. Diversity might potentially be improved by promoting dietary patterns rich in microbial strains. Various collections of bacterial cultures resulting from a century of dairy research are readily available worldwide, and could be exploited to contribute towards this end. We have conducted a functional in silico analysis of the metagenome of 24 strains, each representing one of the species in a bacterial culture collection composed of 626 sequenced strains, and compared the pathways potentially covered by this metagenome to the intestinal metagenome of four healthy, although overweight, humans. Remarkably, the pan-genome of the 24 strains covers 89% of the human gut microbiome’s annotated enzymatic reactions. Furthermore, the dairy microbial collection covers biological pathways, such as methylglyoxal degradation, sulfate reduction, γ-aminobutyric (GABA) acid degradation and salicylate degradation, which are differently covered among the four subjects and are involved in a range of cardiometabolic, intestinal, and neurological disorders. We conclude that microbial culture collections derived from dairy research have the genomic potential to complement and restore functional redundancy in human microbiomes.

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“…Previous studies have shown that bacteria of the genera Bacillus and Cellulomonas are included in probiotic preparations for animals, which exert anti-inflammatory effects on the intestinal barrier ( 51 , 52 ). Moreover, a previous study reported that Bacillus in the cecal digesta of mice was positively associated with TMA lyase activity ( 53 ). It is well established that TMA lyase plays a key role in converting choline to TMA and then it is oxidized to TMAO; thus, the increased abundance of Bacillus is in line with the higher plasma TMAO concentration in the current study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Choline Levels During Pregnancy on Reproductive Performance, Plasma Metabolome and Gut Microbiota of Sows

Zhong

Zhao

et al. 2022

Front. Vet. Sci.

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This study investigated the effects of dietary choline levels during gestation on reproductive performance of sows. In addition, the plasma metabolome and gut microbiota of sows was studied. A total of 260 multiparous sows were allocated to five dietary treatment groups with increasing choline concentrations (1,050, 1,450, 1,850, 2,250, and 2,650 mg/kg) in a randomized complete block design. The sows were fed experimental diets from breeding until farrowing and a common lactating diet during lactation. The results showed that the backfat (BF) gain of sows during gestation, individual birth weight for total piglets born, piglets born alive, average piglet weight at weaning increased linearly (P < 0.05), whereas the within-litter birth weight variation coefficient (CV) of piglets born alive and suckling piglet mortality decreased linearly (P < 0.05) as dietary choline level increased. A quadratic effect of dietary choline level was observed for the average daily feed intake (ADFI) of sows during lactation (P < 0.05). ADFI was maximized when the dietary choline concentration reached 1,910 mg/kg. Plasma H2O2 concentration at day 30 of gestation in the 1,050 mg/kg group was greater than that in the 1,850 and 2,650 mg/kg groups (P < 0.05). Plasma metabolomics identified 46 metabolites among the three groups. Specifically, plasma concentrations of trimethylamine-N-oxide (TMAO), dopamine, and L-proline increased while 1-methylhistidine concentration decreased as dietary choline levels increased. In addition, bacterial observed species and richness (Chao 1 and ACE) at day 110 of gestation decreased as dietary choline levels increased (P < 0.05). For the gut microbiota composition, the enhanced dietary choline level decreased the abundance of phylum Proteobacteria (P < 0.05) and increased the abundance of phylum Actinobacteria (P < 0.05) at day 30 of gestation. Compared with the 1,050 mg/kg group, the abundance of genus Terrisporobacter was less in the 1,850 mg/kg group, and genera Bacillus and Cellulomonas were greater in the 2,650 mg/kg group. In summary, increasing dietary choline levels improved the birth weight, uniformity of neonatal piglets and litter performance during lactation. This may be associated with better antioxidant capability, metabolic status, and gut microbiota of sows during gestation.

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Potential Correlation between Dietary Fiber-Suppressed Microbial Conversion of Choline to Trimethylamine and Formation of Methylglyoxal

Cited by 15 publications

References 57 publications

Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges

Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges

In Silico Comparison Shows that the Pan-Genome of a Dairy-Related Bacterial Culture Collection Covers Most Reactions Annotated to Human Microbiomes

Effects of Dietary Choline Levels During Pregnancy on Reproductive Performance, Plasma Metabolome and Gut Microbiota of Sows

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