Potential Cytotoxic Effects of Peptide Fractions from <i>Dunaliella salina</i> Protein Hydrolyzed by Gastric Proteases

Darvish, Maliheh; Jalili, Hasan; Siadat, Seyed Omid Ranaei; Sedighi, Mehdi

doi:10.1080/10498850.2017.1414095

Cited by 27 publications

(10 citation statements)

References 27 publications

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“…These harmful bacteria were also inhibited by the AQ-1766 peptide extracted from marine microalgae, e.g., Tetraselmis suecica with minimal bactericidal concentrations (MBC) of 40–50 μM [ 278 ]. Similar bioactivities have also been reported for protein hydrolysates and peptides produced from other species such as D. salina [ 260 ] and Chlorella pyrenoidosa [ 279 ]. The peptide, Pa-MAP, isolated from the polar fish ( Pleuronectes americanus ) was recently in the spotlight due to its strong antiviral activity inhibiting 90% of HSV, compared to 97% by LL-37 (another known antiviral peptide) and 99% by antiviral drug acyclovir (ACV) [ 45 ].…”

Section: Nutritional Quality and Biological Activities Of Marine-dsupporting

confidence: 79%

“…Similar result was also observed for peptides produced from marine microalgae. Peptide fractions of <3 kDa obtained from Dunaliella salina by enzymatic hydrolysis decreased viability of SW480 cell by 50% at a concentration of 0.08 μM [ 260 ]. Anticancer properties of peptides may be attributed by the presence of charged (glutamic acid) and heterocyclic amino acid (proline) in their sequences.…”

Section: Nutritional Quality and Biological Activities Of Marine-dmentioning

confidence: 99%

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Protein Recovery from Underutilised Marine Bioresources for Product Development with Nutraceutical and Pharmaceutical Bioactivities

2020

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The global demand for dietary proteins and protein-derived products are projected to dramatically increase which cannot be met using traditional protein sources. Seafood processing by-products (SPBs) and microalgae are promising resources that can fill the demand gap for proteins and protein derivatives. Globally, 32 million tonnes of SPBs are estimated to be produced annually which represents an inexpensive resource for protein recovery while technical advantages in microalgal biomass production would yield secure protein supplies with minimal competition for arable land and freshwater resources. Moreover, these biomaterials are a rich source of proteins with high nutritional quality while protein hydrolysates and biopeptides derived from these marine proteins possess several useful bioactivities for commercial applications in multiple industries. Efficient utilisation of these marine biomaterials for protein recovery would not only supplement global demand and save natural bioresources but would also successfully address the financial and environmental burdens of biowaste, paving the way for greener production and a circular economy. This comprehensive review analyses the potential of using SPBs and microalgae for protein recovery and production critically assessing the feasibility of current and emerging technologies used for the process development. Nutritional quality, functionalities, and bioactivities of the extracted proteins and derived products together with their potential applications for commercial product development are also systematically summarised and discussed.

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Section: Nutritional Quality and Biological Activities Of Marine-dsupporting

confidence: 79%

Section: Nutritional Quality and Biological Activities Of Marine-dmentioning

confidence: 99%

Protein Recovery from Underutilised Marine Bioresources for Product Development with Nutraceutical and Pharmaceutical Bioactivities

2020

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“…These studies, antioxidant and ACE potential have been confirmed in vitro for other microalgae hydrolysates obtained from C. vulgaris , Porphyra dioica , Fucus spiralis [ 234 , 260 , 261 ]. Bioactive peptides with anti-cancer and immunomodulating activities have also been described in the literature for C. vulgaris , C. pyrenoidosa and Dunaliella salina [ 262 , 263 , 264 , 265 ]. The most commonly followed method of bioactive peptides generation from microalgae involves enzymatic digestion of microalgae protein concentrates followed by fractionation using milder techniques such as UF at different membrane pore sizes (3–30 kDa) followed by chromatographic purification.…”

Section: Bioactive Properties Of Non-meat Proteinsmentioning

confidence: 99%

Alternative Protein Sources and Novel Foods: Benefits, Food Applications and Safety Issues

et al. 2023

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The increasing size of the human population and the shortage of highly valuable proteinaceous ingredients has prompted the international community to scout for new, sustainable, and natural protein resources from invertebrates (e.g., insects) and underutilized legume crops, unexploited terrestrial and aquatic weeds, and fungi. Insect proteins are known for their nutritional value, being rich in proteins with a good balance of essential amino acids and being a valuable source of essential fatty acids and trace elements. Unconventional legume crops were found rich in nutritional, phytochemical, and therapeutic properties, showing excellent abilities to survive extreme environmental conditions. This review evaluates the recent state of underutilized legume crops, aquatic weeds, fungi, and insects intended as alternative protein sources, from ingredient production to their incorporation in food products, including their food formulations and the functional characteristics of alternative plant-based proteins and edible insect proteins as novel foods. Emphasis is also placed on safety issues due to the presence of anti-nutritional factors and allergenic proteins in insects and/or underutilized legumes. The functional and biological activities of protein hydrolysates from different protein sources are reviewed, along with bioactive peptides displaying antihypertensive, antioxidant, antidiabetic, and/or antimicrobial activity. Due to the healthy properties of these foods for the high abundance of bioactive peptides and phytochemicals, more consumers are expected to turn to vegetarianism or veganism in the future, and the increasing demand for such products will be a challenge for the future.

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“…3. Micro-and macroalgae bioactive compounds and their bioactivity in humans (based on information from: Anam et al, 2017;Anekthanakul et al, 2019;Barkia et al, 2019;Barton et al, 2016;Darvish et al, 2018;Fan et al, 2017;Fitzgerald et al, 2013;Furuta et al, 2016;Hannan et al, 2020;Indumathi and Mehta, 2016;Li et al, 2019;Mao et al, 2017;Verdugo-González et al, 2019;Wu et al, 2014).…”

Section: Nutritional Aspectsmentioning

confidence: 99%

Algal proteins: Production strategies and nutritional and functional properties

Geada

Moreira

Silva

et al. 2021

Bioresource Technology

145

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Potential Cytotoxic Effects of Peptide Fractions from Dunaliella salina Protein Hydrolyzed by Gastric Proteases

Cited by 27 publications

References 27 publications

Protein Recovery from Underutilised Marine Bioresources for Product Development with Nutraceutical and Pharmaceutical Bioactivities

Protein Recovery from Underutilised Marine Bioresources for Product Development with Nutraceutical and Pharmaceutical Bioactivities

Alternative Protein Sources and Novel Foods: Benefits, Food Applications and Safety Issues

Algal proteins: Production strategies and nutritional and functional properties

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