Potential dependent superiority of gold nanoparticles in comparison to iodinated contrast agents

Jackson, Price; Rahman, Wan Nordiana; Wong, Christopher J.; Ackerly, Trevor; Geso, Moshi

doi:10.1016/j.ejrad.2009.03.057

Cited by 111 publications

(100 citation statements)

References 15 publications

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“…Therefore, empirical results rigorously obtained with a clinical CT scanner are valuable. Others have reported testing a subset of the elements we evaluated, with varying levels of rigor (9,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)23,24,(26)(27)(28)(29)(30). Examples of shortcomings in literature reports include the following: (a) Too few elements were evaluated (11,(13)(14)(15)(16)(17)(18)(19)(20)23,24,26,27,29); (b) elemental concentrations were unverified and/or uncorrected or were based on molarity rather than mass (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)23,(26)(27)(28)(29); (c) no patient-relevant phantom was used (11,…”

Section: Contrast Media: Ct Image Contrast Of High-z Elements: Phantomentioning

confidence: 99%

“…To evaluate the effect of even larger subjects and to consider possible x-ray spectrum optimization, we added filters at the x-ray tube output of 0.2-, 0.5-, and 1.0-mm-thick copper. We reconstructed 0.625-mm-thick images by using a "standard" kernel into a 512 3 512-voxel 32-cm field of view, resulting (5,9,(11)(12)(13)(16)(17)(18)(19)(20)23,24,26,28,29); (f) considerations that affect the measured image contrast were unaccounted for and/or uncorrected, such as the solvent in which the tested compound was dissolved (23,28) and elements other than the active element in the compound (11,18,23,26,28); and (g) image contrast (in Hounsfield units) was not explicitly or precisely reported (11,12,17,20,24,26,28,29).…”

Section: Ct Imaging and Image Contrast Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

CT Image Contrast of High-ZElements: Phantom Imaging Studies and Clinical Implications

Fitzgerald¹,

Colborn²,

Edic³

et al. 2016

Radiology

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Purpose:To quantify the computed tomographic (CT) image contrast produced by potentially useful contrast material elements in clinically relevant imaging conditions. Materials and Methods:Equal mass concentrations (grams of active element per milliliter of solution) of seven radiodense elements, including iodine, barium, gadolinium, tantalum, ytterbium, gold, and bismuth, were formulated as compounds in aqueous solutions. The compounds were chosen such that the active element dominated the x-ray attenuation of the solution. The solutions were imaged within a modified 32-cm CT dose index phantom at 80, 100, 120, and 140 kVp at CT. To simulate larger body sizes, 0.2-, 0.5-, and 1.0-mmthick copper filters were applied. CT image contrast was measured and corrected for measured concentrations and presence of chlorine in some compounds. Results:Each element tested provided higher image contrast than iodine at some tube potential levels. Over the range of tube potentials that are clinically practical for averagesized and larger adults-that is, 100 kVp and higher-barium, gadolinium, ytterbium, and tantalum provided consistently increased image contrast compared with iodine, respectively demonstrating 39%, 56%, 34%, and 24% increases at 100 kVp; 39%, 66%, 53%, and 46% increases at 120 kVp; and 40%, 72%, 65%, and 60% increases at 140 kVp, with no added x-ray filter. Conclusion:The consistently high image contrast produced with 100-140 kVp by tantalum compared with bismuth and iodine at equal mass concentration suggests that tantalum could potentially be favorable for use as a clinical CT contrast agent.q RSNA, 2015

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Section: Contrast Media: Ct Image Contrast Of High-z Elements: Phantomentioning

confidence: 99%

Section: Ct Imaging and Image Contrast Measurementsmentioning

confidence: 99%

CT Image Contrast of High-ZElements: Phantom Imaging Studies and Clinical Implications

Fitzgerald¹,

Colborn²,

Edic³

et al. 2016

Radiology

View full text Add to dashboard Cite

show abstract

“…Iodine has a lower atomic number than gold and bismuth; it, however, exhibits higher elemental mass attenuation coefficient and incident X-ray energies so that, when compared to gold NPs under conditions used for coronary angiography, iodinated CAs had an equivalent performance [236] . When a CA was developed by combining the two radiodense elements iodine and gold within a single PAMAM dendrimer, it was demonstrated that the incorporation of both Au NPs and iodine-containing small molecules resulted in a significant cooperative enhancing effect in X-ray attenuation [237] .…”

Section: Iodinated Nanoparticlesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…The purpose of these nanomaterials is to locally increase iodine concentrations, Some multimodal nanoparticles were doped with an iodinated compound and used to enhance X-ray contrast [216,224,234,235] as discussed in later on in the review. Iodine has a lower atomic number than gold and bismuth, it however exhibits higher elemental mass attenuation coefficient and incident X-ray energies so that when compared to gold NPs under conditions used for coronary angiography, iodinated contrast agents had equivalent performance [236].…”

Section: Iodinated Nanoparticlesmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

View full text Add to dashboard Cite

The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

show abstract

Potential dependent superiority of gold nanoparticles in comparison to iodinated contrast agents

Cited by 111 publications

References 15 publications

CT Image Contrast of High-ZElements: Phantom Imaging Studies and Clinical Implications

CT Image Contrast of High-ZElements: Phantom Imaging Studies and Clinical Implications

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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