Potential determinants of efficacy of mirror therapy in stroke patients – A pilot study

Brunetti, Maddalena; Morkisch, Nadine; Fritzsch, Clairea; Mehnert, Jan; Steinbrink, Jens; Niedeggen, Michael; Dohle, Christian

doi:10.3233/rnn-140421

Cited by 37 publications

(65 citation statements)

References 47 publications

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“…Whether the stroke types or different lesion sites of patients (e.g., mirror neurons affected or not) influence the treatment efficacy of the action observation therapy or mirror therapy will need to be investigated in the future. In addition, early studies found that the initial motor function of stroke patients was a significant predictor or a critical determinant of motor recovery after receiving rehabilitation therapies [49][50][51]. Whether the baseline severity of the upper limb motor deficits of the patients affects the treatment efficacy of the action observation therapy and mirror therapy needs to be further investigated.…”

Section: Variablesmentioning

confidence: 99%

Treatment Effects of Upper Limb Action Observation Therapy and Mirror Therapy on Rehabilitation Outcomes after Subacute Stroke: A Pilot Study

Hsieh

Lin

Zhu

et al. 2020

Behavioural Neurology

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Background. Action observation therapy and mirror therapy, two promising rehabilitation strategies, are aimed at enhancing the motor learning and functional improvement of stroke patients through different patterns of visual feedback and observation. Objective. This study investigated and compared the treatment effects of the action observation therapy, mirror therapy, and active control intervention on motor and functional outcomes of stroke patients. Methods. Twenty-one patients with subacute stroke were recruited in this study. All patients were randomly assigned to the action observation therapy, mirror therapy, or active control intervention for 3 weeks. Outcome measures were conducted at baseline, immediately after treatment, and at 3-month follow-up. The primary outcome was the Fugl-Meyer Assessment, and secondary outcomes included the Box and Block Test, Functional Independence Measure, and Stroke Impact Scale. Descriptive analyses and the number of patients whose change score achieved minimal clinically important difference were reported. Results. Both the action observation therapy and active control intervention showed similar improvements on the Fugl-Meyer Assessment, Box and Block Test, and Stroke Impact Scale. Moreover, the action observation therapy had a greater improvement on the Functional Independence Measure than the other 2 groups did. However, the mirror therapy group gained the least improvements on the outcomes. Conclusion. The preliminary results found that the patients in the action observation therapy and active control intervention groups had comparable benefits, suggesting that the 2 treatments might be used as an alternative to each other. A further large-scale study with at least 20 patients in each group to validate the study findings is needed. This trial is registered with NCT02871700.

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Section: Variablesmentioning

confidence: 99%

Treatment Effects of Upper Limb Action Observation Therapy and Mirror Therapy on Rehabilitation Outcomes after Subacute Stroke: A Pilot Study

Hsieh

Lin

Zhu

et al. 2020

Behavioural Neurology

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“…In contrast, no change in wrist motor function was observed. Brunetti et al, in 2015 conducted a study to deter- This study concluded that the base level of voluntary movement is one main factor that affects potential motor recovery after MT [20]. As the participants in our study had very minimal voluntary movement in the wrist, we can interpret it as a potential reason for this result in their wrist motor function.…”

Section: Discussionmentioning

confidence: 56%

The Effectiveness of Mirror Therapy on Upper Limb Function in Stroke Patients: A Single Case Experimental Design

et al. 2019

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To assess the effectiveness of Mirror Therapy (MT) on Upper Limb (UL) function of sub-acute stroke patients. Methods: This study is a single case experimental design with two participants. Twenty minutes of MT were implemented four times a week over a period of four weeks. For baseline phase, repeated measurements were performed six times for one participant and four times for the other participant using Fugl-Meyer Motor Function Assessment (FMA), and it was applied twice a week during the intervention phase. Brunnstrom Recovery Stages (BRS) and Barthel Index (BI) were applied once before the baseline phase, as well as prior and after the intervention phase. Results: Based on Percentage of Non-overlapping Data (PND) for FMA subtests, MT had questionable effectiveness on UL for both participants, and MT was unreliable intervention on wrist function. For the hand, of the second participant, MT had questionable effectiveness, whereas for the first participant it was unreliable intervention. For coordination, MT was fairly effective for the first participant and had questionable effectiveness for the second participant. BRS-Arm scores indicated improvements for the second participant from 3 (out of 6) to 4. BRS-Hand scores indicated improvements for the first participant from 5 (out of 6) to 6. No changes were shown in BI. Discussion: This study revealed that MT had positive effects on some sections of UL motor function and coordination, whereas no change in wrist motor function was observed. No functional improvements in BI and slight difference in BRS were noticed.

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“…278 The cortical activation in the precuneus region in stroke patients was linked to mirror therapy, and it could be used to determine the e±cacy of the therapy. 279 In a longitudinal study, revascularization surgeries performed on stroke patients resulted in improvements as compared to the levels before surgery, the CBF Fig. 10.…”

Section: Hand/¯nger Movement Taskmentioning

confidence: 98%

Application of functional near-infrared spectroscopy in the healthcare industry: A review

Hong

Yaqub

2019

J. Innov. Opt. Health Sci.

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Functional near-infrared spectroscopy (fNIRS), a growing neuroimaging modality, has been utilized over the past few decades to understand the neuronal behavior in the brain. The technique has been used to assess the brain hemodynamics of impaired cohorts as well as able-bodied. Neuroimaging is a critical technique for patients with impaired cognitive or motor behaviors. The portable nature of the fNIRS system is suitable for frequent monitoring of the patients who exhibit impaired brain activity. This study comprehensively reviews brain-impaired patients: The studies involving patient populations and the diseases discussed in more than 10 works are included. Eleven diseases examined in this paper include autism spectrum disorder, attention-deficit hyperactivity disorder, epilepsy, depressive disorders, anxiety and panic disorder, schizophrenia, mild cognitive impairment, Alzheimer’s disease, Parkinson’s disease, stroke, and traumatic brain injury. For each disease, the tasks used for examination, fNIRS variables, and significant findings on the impairment are discussed. The channel configurations and the regions of interest are also outlined. Detecting the occurrence of symptoms at an earlier stage is vital for better rehabilitation and faster recovery. This paper illustrates the usability of fNIRS for early detection of impairment and the usefulness in monitoring the rehabilitation process. Finally, the limitations of the current fNIRS systems (i.e., nonexistence of a standard method and the lack of well-established features for classification) and future research directions are discussed. The authors hope that the findings in this paper would lead to advanced breakthrough discoveries in the fNIRS field in the future.

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Potential determinants of efficacy of mirror therapy in stroke patients – A pilot study

Cited by 37 publications

References 47 publications

Treatment Effects of Upper Limb Action Observation Therapy and Mirror Therapy on Rehabilitation Outcomes after Subacute Stroke: A Pilot Study

Treatment Effects of Upper Limb Action Observation Therapy and Mirror Therapy on Rehabilitation Outcomes after Subacute Stroke: A Pilot Study

The Effectiveness of Mirror Therapy on Upper Limb Function in Stroke Patients: A Single Case Experimental Design

Application of functional near-infrared spectroscopy in the healthcare industry: A review

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