“…1 ). Previous studies have reported that mutations in 57 genes may cause or be associated with HCM, including eight definitive genes (MYBPC3, MYH7, TNNT2, TNNI3, TPM1, ACTC1, MYL2 and MYL3), three moderately evidenced genes [cysteine and glycine-rich protein 3 (CSRP3), troponin C and junctophilin-2] and other genes with limited or no evidence (titin, Krueppel-like factor 10, myopalladin, ankyrin repeat domain-containing protein 1, myosin light chain kinase 2, myozenin-2, nexilin, vinculin, E3 ubiquitin-protein ligase TRIM63, ryanodine receptor 2, MYH6, obscurin, PDZ and LIM domain protein 3, telethonin, myomesin-1 and calreticulin-3) ( 23-27 ). Therefore, the present study focused on the genetic variations (SNPs and indels) occurring in any of the aforementioned genes.…”