Potential Dopamine-1 Receptor Stimulation in Hypertension Management

Abstract

The role of dopamine receptors in blood pressure regulation is well established. Genetic ablation of both dopamine D1-like receptor subtypes (D1, D5) and D2-like receptor subtypes (D2, D3, D4) results in a hypertensive phenotype in mice. This review focuses on the dopamine D1-like receptor subtypes D1 and D5 (especially D1 receptors), as they play a major role in regulating sodium homeostasis and blood pressure. Studies mostly describing the role of renal dopamine D1-like receptors are included, as the kidneys play a pivotal role in the maintenance of sodium homeostasis and the long-term regulation of blood pressure. We also attempt to describe the interaction between D1-like receptors and other proteins, especially angiotensin II type 1 and type 2 receptors, which are involved in the maintenance of sodium homeostasis and blood pressure. Finally, we discuss a new concept of renal D1 receptor regulation in hypertension that involves oxidative stress mechanisms.

Asociación y efectos de interacción en los genes AGT, AGTR1, ACE, ADRB2, DRD1, ADD1, ADD2, ATP2B1, TBXA2R y PTGS2 sobre la hipertensión en población antioqueña

“…Los efectos de interacción entre los genes DRD1-AGT y DRD1-AGTR1, son coherentes con hallazgos previos que reportan la existencia de interacción funcional entre los genes del sistema RAAS y el sistema dopaminérgico. La dopamina renal es uno de los principales reguladores de la excreción de sodio renal con efectos natriuréticos y diuréticos (37). En forma similar a la dopamina, los péptidos del sistema renina-angiotensina-aldosterona RAS, contribuyen de manera importante a la regulación de la homeostasis del sodio por medio de los receptores AGTR1 y AGTR2, por lo cual se han llevado a cabo varios estudios con el fin de comprender la relación existente entre el sistema dopaminérgico y el sistema RAAS, encontrándose que existe una interacción entre estos factores (87,89).…”

“…Los principales sistemas fisiológicos que se encuentran involucrados en el control de la presión arterial son el sistema renina-angiotensina-aldosterona, el endotelio vascular, la transducción de señales por vía del sistema nervioso y las proteínas del citoesqueleto, que se encargan del mantenimiento del flujo sanguíneo (presión sanguínea y volumen de fluidos extracelulares en el cuerpo), mediación de reacciones de vasodilatación-vasoconstricción y la regulación de la concentración de sales (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44).…”

762 Activation of D4 Dopamine Receptor Decreases At1 Angiotensin Ii Receptor Expression in Rat Renal Proximal Tubule Cells

“…Dopamine and angiotensin II are two important regulators of sodium and water transport in the kidney serving counteracting functions 2,3,10,11,14,16 . Stimulation of the D 1 -like dopamine receptor inhibits renal renin secretion via inhibition of macula densa cyclooxygenase 27 .…”

“…Dopamine receptors, like AT 1 receptor, are expressed in the brush border and basolateral membranes of the RPT 3 . In contrast to the stimulatory effect of the AT 1 receptor on sodium transport in the RPT, the major consequence of the activation of dopamine receptors is inhibition of sodium transport 2,3 .…”

“…Dopamine receptors, like AT 1 receptor, are expressed in the brush border and basolateral membranes of the RPT 3 . In contrast to the stimulatory effect of the AT 1 receptor on sodium transport in the RPT, the major consequence of the activation of dopamine receptors is inhibition of sodium transport 2,3 . According to their structure and pharmacology, dopamine receptors are classified into D 1 Increasing pieces of evidence show interaction between dopamine and angiotensin II receptors 2 .…”