Potential Drug Candidates Underway Several Registered Clinical Trials for Battling COVID-19

Abstract

The emergence of new type of viral pneumonia cases in China, on December 31, 2019; identified as the cause of human coronavirus, labeled as "COVID-19," took a heavy toll of death and reported cases of infected people all over the world, with the potential to spread widely and rapidly, achieved worldwide prominence but arose without the procurement guidance. There is an immediate need for active intervention and fast drug discovery against the 2019-nCoV outbreak. Herein, the study provides numerous candidates of drugs (either alone or integrated with another drugs) which could prove to be effective against 2019-nCoV, are under different stages of clinical trials. This review will offer rapid identification of a number of repurposable drugs and potential drug combinations targeting 2019-nCoV and preferentially allow the international research community to evaluate the findings, to validate the efficacy of the proposed drugs in prospective trials and to lead potential clinical practices.

Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives

“…Structurally comparable to the darunavir, the TMC-310911 is a potent protease inhibitor that has been initially demonstrated for treating human immunodeficiency virus (HIV)-1 infections due to its proteolytic cleavage protection (Mina et al, 2020). Nowadays, several multinational companies are trying to develop the antiviral activity of this drug as a discerning agent against SARS-CoV-2 in combination with other HIV therapies, including ritonavir and lopinavir (Mina et al, 2020).…”

“…Structurally comparable to the darunavir, the TMC-310911 is a potent protease inhibitor that has been initially demonstrated for treating human immunodeficiency virus (HIV)-1 infections due to its proteolytic cleavage protection (Mina et al, 2020). Nowadays, several multinational companies are trying to develop the antiviral activity of this drug as a discerning agent against SARS-CoV-2 in combination with other HIV therapies, including ritonavir and lopinavir (Mina et al, 2020). Ascletis Pharmaceuticals Co., Ltd. is one of these multinational companies that provides information about an open-label trial (NCT04261907) of ASC09/ritonavir (300 mg/100 mg tablet) and lopinavir/ritonavir (200 mg/50 mg tablet), which are experimented on 160 participants to evaluate and compare their effectiveness in COVID-19 (Clinicaltrials.Gov, 2020ak).…”