Potential drug-drug interactions in elderly patients presenting with syncope

Gaeta, Theodore J.; Fiorini, Melissa; Ender, Kimberly; Bove, Joseph; Díaz, José Antonio Pajares

doi:10.1016/s0736-4679(01)00471-1

Cited by 28 publications

(17 citation statements)

References 16 publications

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“…Most studies addressing the incidence of pDDI among the elderly were performed in outpatient health care services (Björkman et al, 2002;Gaeta et al, 2002;Obreli Neto et al, 2012;Secoli et al, 2010). An investigation involving six European countries reported that 46% of elderly outpatients had been exposed to at least one clinically relevant pDDI (Björkman et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients?

Melo

Storpirtis

Ribeiro

2016

Braz. J. Pharm. Sci.

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The purpose of the work was to assess the incidence of potential drug interactions (pDDI), major pDDI, and the use of potentially inappropriate medication (PIM) at hospital admission, during hospitalization, and at discharge to evaluate whether hospital admission provides an opportunity for improving pharmacotherapy in elderly patients at a University hospital that has a clinical pharmacist. A prospective cohort study was carried out using data from the medical records of patients admitted to an internal medicine ward. All admissions and prescriptions were monitored between March and August 2006. Micromedex® DrugReax® and Beers Criteria 2015 were used to identify pDDI, major pDDI, and PIMs, respectively. A comparison of admission and discharge prescriptions showed the following: an increase in the proportion of patients using antithrombotic agents (76 versus 144; p<0.001), lipid modifying agents (58 versus 81; p=0.024), drugs for acid-related disorders (99 versus 152; p<0.001), and particularly omeprazole (61 versus 87; p=0.015); a decrease in the number of patients prescribed psycholeptics (73 versus 32; p<0.001) and diazepam (54 versus 13; p<0.001); and a decrease in the proportion of patients exposed to polypharmacy (16.1% versus 10.1%; p=0.025), at least one pDDI (44.5% versus 32.8%; p=0.002), major pDDI (19.9% versus 12.2%; p=0.010) or PIM (85.8% versus 51.9%; p<0.001). The conclusion is that admission to a hospital ward that has a clinical pharmacist was associated with a reduction in the number of patients exposed to polypharmacy, pDDI, major pDDI, and the use of PIMs among elderly inpatients.Uniterms:. Health Services/elderly patients. Internal Medicine/hospitals. Clinical Pharmacy. Drug interactions. Drug prescriptions.

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Section: Discussionmentioning

confidence: 99%

Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients?

Melo

Storpirtis

Ribeiro

2016

Braz. J. Pharm. Sci.

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“…Variables such as age, polimedication, and the state of disease increase the probability of an interaction (16,22,33,54,55). The percentage of serious ADR reports and the number of drugs in our study was higher in reports on actual drug-drug interactions than among the remaining reports (15,29,56).…”

Section: Discussionmentioning

confidence: 99%

“…Potential drug-drug interactions are defined on the basis of on retrospective chart reviews and actual drug-drug interactions are defined on the basis of clinical evidence, ie, they are confirmed by laboratory tests or symptoms (33). The frequency of potential interactions is higher than that of actual interactions, resulting in large discrepancies among study findings (24).…”

mentioning

confidence: 99%

Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study

et al. 2011

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AimTo analyze potential and actual drug-drug interactions reported to the Spontaneous Reporting Database of the Croatian Agency for Medicinal Products and Medical Devices (HALMED) and determine their incidence.MethodsIn this retrospective observational study performed from March 2005 to December 2008, we detected potential and actual drug-drug interactions using interaction programs and analyzed them.ResultsHALMED received 1209 reports involving at least two drugs. There were 468 (38.7%) reports on potential drug-drug interactions, 94 of which (7.8% of total reports) were actual drug-drug interactions. Among actual drug-drug interaction reports, the proportion of serious adverse drug reactions (53 out of 94) and the number of drugs (n = 4) was significantly higher (P < 0.001) than among the remaining reports (580 out of 1982; n = 2, respectively). Actual drug-drug interactions most frequently involved nervous system agents (34.0%), and interactions caused by antiplatelet, anticoagulant, and non-steroidal anti-inflammatory drugs were in most cases serious. In only 12 out of 94 reports, actual drug-drug interactions were recognized by the reporter.ConclusionThe study confirmed that the Spontaneous Reporting Database was a valuable resource for detecting actual drug-drug interactions. Also, it identified drugs leading to serious adverse drug reactions and deaths, thus indicating the areas which should be in the focus of health care education.

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“…Vários estudos demonstram que a ocorrência de interações medicamentosas está relacionada ao número de medicamentos utilizados pelo paciente (GRAHAME-SMITH; ARONSON, 2004;EGGER, DREWE, SCHLIENGER, 2002;GAETA et al, 2002;KOHLER et al, 2000). Pacientes que utilizam cinco medicamentos têm 50% de Quanto à idade, é freqüente o uso de vários medicamentos pela população idosa que aumenta o risco de IM com pacientes em idades mais avançadas (ROZENFELD, 2003).…”

Section: Interações Medicamentosas Potenciais E O Planejamento Dos Hounclassified

Interações medicamentosas potenciais em pacientes de unidade de terapia intensiva de um hospital universitário do Ceará

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Na prática clínica, é comum a associção de vários fármacos para o tratamento de patologias crônicas. Entretanto, agumas associações podem ter respostas indesejáveis para o paciente que resultam desde a ineficácia do tratamento medicamentoso até eventos adversos graves. As interações medicamentosas (IM) são exemplos de eventos adversos com medicamentos e para sua ocorrência contam-se fatores relacionados ao paciente, medicamento e com a prescrição. Quanto aos fatores de risco relacionados ao paciente, algumas populações, são mais vulneráveis as IM, tais como: idosos, pacientes submetidos à procedimentos cirúrgicos, em unidades de terapia intensiva e imunodeprimidos.

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Potential drug-drug interactions in elderly patients presenting with syncope

Cited by 28 publications

References 16 publications

Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients?

Does hospital admission provide an opportunity for improving pharmacotherapy among elderly inpatients?

Adverse drug reactions caused by drug-drug interactions reported to Croatian Agency for Medicinal Products and Medical Devices: a retrospective observational study

Interações medicamentosas potenciais em pacientes de unidade de terapia intensiva de um hospital universitário do Ceará

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