Potential drug–drug interactions in patients with non-small cell lung cancer at a university hospital in Turkey

Albayrak, Aslınur; Duzenli, Tarik; Kayıkçıoğlu, Erkan

doi:10.1007/s00432-023-04890-0

J Cancer Res Clin Oncol

2023

DOI: 10.1007/s00432-023-04890-0

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Potential drug–drug interactions in patients with non-small cell lung cancer at a university hospital in Turkey

Aslınur Albayrak

Tarik Duzenli

Erkan Kayıkçıoğlu

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2024

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Cited by 2 publications

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Potential Drug-Drug Interactions in Outpatient Lung Cancer Patients in a University Hospital

Jafarova Demirkapu,

Cavdar

2024

Pharmacology

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Introduction: Concomitant use of drugs in the same or different indications can sometimes lead to undesirable interactions. The prevalence of drug interactions is high in cancer patients. In this study, we aimed to determine the frequency and clinical severity of drug interactions in outpatient lung cancer patients. Methods: The drugs used, kidney and liver blood analysis results of 160 outpatient lung cancer patients over the age of 18 who received chemotherapy between October 2020 and July 2021 were evaluated. The Lexi-Interact online database was used to identify the types of clinically significant drug interactions, frequently interacting drugs, and clinical outcomes predicted by the databases. Results: The average number of drugs per patient was 4.2±2.3. It was determined that there was a relationship between multi-drug use and comorbidity, and the number of drugs used increased as the number of diagnoses increased. A relationship was also found between potential drug-drug interactions (pDDI), which we observed in 52.5% of the patients, and the number of drugs used and age. The most common clinically significant C (36.9%), D (16.9%) and X (10.6%) type pDDI were detected between conventional paclitaxel-hydrochlorothiazide, conventional paclitaxel-carboplatin, and ipratropium-tiotropium, respectively. Conclusions: The use of frequently interacting drugs in outpatient lung cancer patients can lead to pDDI. In these patients, the application of therapy by observing the drug-drug interaction may improve the quality of life.

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Potential Drug-Drug Interactions in Outpatient Lung Cancer Patients in a University Hospital

Jafarova Demirkapu,

Cavdar

2024

Pharmacology

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Clinical Pharmacist-Led Interventions for Improving Breast Cancer Management—A Scoping Review

Staynova,

Gavazova,

Kafalova

2024

Current Oncology

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Breast cancer is the leading cause of cancer-related death in women worldwide and the fifth most common cause of cancer death overall. Most women with breast cancer have a good prognosis if the cancer is detected at an early stage and the patients have access to the appropriate treatment and disease management. This study aims to evaluate the impact of pharmacist-led interventions on breast cancer management and health outcomes. A literature review was carried out through the scientific databases PubMed, Scopus, and Web of Science using predefined keywords. Only full-text original articles written in English that investigated the role of the pharmacist in the management of breast cancer were included in the final analysis. No publication date limits were set. A total of 1625 articles were retrieved from the electronic databases, of which 14 met the inclusion criteria. The current scoping review consists of different study types, including randomized controlled trials, cross-sectional studies, pre-post studies, retrospective cohort studies, quality improvement projects, case-control studies, and one pharmacoeconomic study. Pharmacists commonly provided the following interventions: consultations regarding chemotherapy treatment, risk assessment and patient education, adverse drug reactions and drug-drug interactions detection, and adherence assessment. This scoping review highlights the beneficial effects of the involvement of pharmacists in breast cancer management, such as better quality of life, reduced drug interaction risk, greater adherence rates, and improved patient knowledge. This confirms the importance of including the pharmacist in the oncology team caring for patients with breast cancer.

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Potential drug–drug interactions in patients with non-small cell lung cancer at a university hospital in Turkey

Cited by 2 publications

References 41 publications

Potential Drug-Drug Interactions in Outpatient Lung Cancer Patients in a University Hospital

Potential Drug-Drug Interactions in Outpatient Lung Cancer Patients in a University Hospital

Clinical Pharmacist-Led Interventions for Improving Breast Cancer Management—A Scoping Review

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