Potential drug–drug interactions in pediatric outpatient prescriptions for newborns and infants

Yeh, Min-Li; Yj, Chang; Yeh, Su‐Ling; Huang, Li-Jung; Yen, Yung-Tai; Wang, Po-Yen; Li, Yu-Chuan; Hsu, Chien Yeh

doi:10.1016/j.cmpb.2013.07.016

Cited by 24 publications

(19 citation statements)

References 24 publications

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“…Antiepileptic drugs pose a particular risk for DDIs given the high rate of interactions associated with many of these agents, although high rates of DDIs have been documented among hospitalized patients across a spectrum of drug classes. 3,5,13,16,17 Our findings indicate that certain patient characteristics are associated with a higher risk of a pDDI, which may help identify patient populations who require particular vigilance around medication therapies.…”

Section: Discussionmentioning

confidence: 74%

See 1 more Smart Citation

Drug-Drug Interactions Among Hospitalized Children Receiving Chronic Antiepileptic Drug Therapy

Lebowitz

Olson

Burns

et al. 2016

Hospital Pediatrics

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Section: Discussionmentioning

confidence: 74%

“…This definition is consistent with the definitions used in previous studies assessing the prevalence of pDDIs. [12][13][14][15]…”

Section: Drug Selection and Classificationmentioning

confidence: 99%

Drug-Drug Interactions Among Hospitalized Children Receiving Chronic Antiepileptic Drug Therapy

Lebowitz

Olson

Burns

et al. 2016

Hospital Pediatrics

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“…Large retrospective studies usually report well‐understood and probably well‐managed pDDIs, and small prospective studies are needed to identify the potential harm of specific drug–drug combinations . In addition, small prospective studies help to develop practical decision support tools and improve clinicians’ knowledge of prevalent and clinically important DDIs encountered in their daily practice . Therefore, our aim was to identify the rate, mechanism, potential effect, and management of clinically significant DDIs in pediatric patients admitted to the PICU.…”

mentioning

confidence: 99%

“…7 In addition, small prospective studies help to develop practical decision support tools and improve clinicians' knowledge of prevalent and clinically important DDIs encountered in their daily practice. [12][13][14] Therefore, our aim was to identify the rate, mechanism, potential effect, and management of clinically significant DDIs in pediatric patients admitted to the PICU.…”

mentioning

confidence: 99%

Potential Drug–Drug Interactions Among Critically Ill Pediatric Patients in a Tertiary Pulmonary Center

Hassanzad

Arenas-López

Baniasadi

2017

The Journal of Clinical Pharma

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Patients in the pediatric intensive care unit (PICU) are at increased risk of potential drug-drug interactions (pDDIs) because of the complexity of pharmacotherapy. The current study aimed to assess the rate, pattern, risk factors, and management of pDDIs in the PICU of an academic pulmonary hospital. A prospective observational study was conducted for 6 months. Pharmacotherapy data of PICU-admitted patients were evaluated by a clinical pharmacologist. Interacting drugs, reliability, mechanism, potential outcome, and clinical management of pDDIs were identified using the Lexi-Interact database. Logistic regression was applied to analyze the risk factors that could be associated with the interactions. One hundred and twenty-three medication profiles were evaluated during the study period. Diseases of the respiratory system were the main diagnoses among intensive care unit (ICU)-admitted patients (56.1%). A total of 38.6% of the patients exposed to at least 1 major and/or contraindicated interaction during ICU admission. Most pDDIs occurred through metabolic (35.4%) and additive (34.8%) mechanisms. The existence of pDDIs was significantly associated with the number of prescribed medications. Exposure to pDDIs is frequent in critically ill pediatric patients and related to the number of medications. Daily and close cooperation between clinicians and clinical pharmacologists is recommended to prevent harmful outcomes of DDIs.

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“…A few studies describe general in-, and outpatient populations in hospital settings [9, 12, 13], whereas data that focus on specific patient groups are more frequent [10, 14–19]. However, pediatric potential DDIs in the general outpatient setting, including primary health care, have not been studied in patients older than 12 months, to the best of our knowledge [20].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of potential drug-drug interactions in Swedish pediatric outpatients

et al. 2019

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Purpose To describe the occurrence of potential drug-drug interactions (DDIs) in prescribed drugs, dispensed to pediatric outpatients in Sweden. Methods A cross sectional study was conducted based on data from a national register of prescribed drugs, dispensed at pharmacies, to children 0–17 years old. The study period was January 1 to April 30, 2010. Drug dispensing data was linked to the DDI database SFINX. Prevalence and frequencies of potential interactions were investigated, and drugs commonly involved in interactions were identified. The study focused on clinically relevant potential interactions, class D (should be avoided), and class C (can be handled, e.g. by dose adjustment). Results In the Swedish pediatric population, 0 to 17 years of age, 12% (n = 231 078) of children had at least two dispensed drugs. In this group of patients, 0.14% had potential D-interactions and 1,3% had potential C-interactions. The number of D- and C-interactions that may lead to reduced effects were 181 (52%), and 1224 (32%) respectively. The ten most frequent drugs were involved in 78% and 65% of all potential D-, and C-interactions respectively. Furthermore, 80%, and 58% of the D-, and C-interactions respectively occurred in patients aged 12 to 17. Conclusions We identified a limited number of drugs that were represented in the majority of potential interactions. Interactions that can lead to a reduced treatment effect constituted approximately half of D-interactions, and a third of C-interactions. The frequency of potential interactions was higher in older children. The results may contribute to increased prescriber awareness of important potential drug interactions among pediatric outpatients.

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Potential drug–drug interactions in pediatric outpatient prescriptions for newborns and infants

Cited by 24 publications

References 24 publications

Drug-Drug Interactions Among Hospitalized Children Receiving Chronic Antiepileptic Drug Therapy

Drug-Drug Interactions Among Hospitalized Children Receiving Chronic Antiepileptic Drug Therapy

Potential Drug–Drug Interactions Among Critically Ill Pediatric Patients in a Tertiary Pulmonary Center

Prevalence of potential drug-drug interactions in Swedish pediatric outpatients

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