2021
DOI: 10.1016/j.jep.2021.113854
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Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification

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Cited by 59 publications
(29 citation statements)
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“…According to sequence alignment and homology modeling, the critical targets of spike, 3C-like protease (3CLpro), papain-like protease (PLpro), and RNA-dependent RNA polymerase (RdRp) protease share 76%, 96%, 83%, 96% sequence similarity between SARS-CoV and SARS-CoV-2, respectively 85 , 86 , 87 . We collected and summarized TCMs and their ingredients to reveal the specific mechanisms of TCM for the three phases of distinct disease stages of COVID-19 42 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , …”
Section: Potential Mechanisms Of Tcm For Covid-19mentioning
confidence: 99%
“…According to sequence alignment and homology modeling, the critical targets of spike, 3C-like protease (3CLpro), papain-like protease (PLpro), and RNA-dependent RNA polymerase (RdRp) protease share 76%, 96%, 83%, 96% sequence similarity between SARS-CoV and SARS-CoV-2, respectively 85 , 86 , 87 . We collected and summarized TCMs and their ingredients to reveal the specific mechanisms of TCM for the three phases of distinct disease stages of COVID-19 42 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , …”
Section: Potential Mechanisms Of Tcm For Covid-19mentioning
confidence: 99%
“…With respect to supporting experimental evidence, effects of Glycyrrhiza glabra root extract on ACE2 expression have not been reported so far but the present data are consistent with the action of an extract of another plant, namely Glycyrrhiza uralensis, in the lung tissue of mice [ 37 ]. Other supporting data show that extract of Glycyrrhiza glabra or its main components may affect affinity interactions with ACE2 and/or viral proteases [ 38 , 39 , 40 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is important to understand which herbs and their active ingredients have potential inhibitory effects on ACE2. Here, we list the commonly used herbal prescriptions ( Perez-Roses et al, 2015 ; Saranya et al, 2017 ; Chuan et al, 2020 ; Feng et al, 2020 ; Huang L. et al, 2020 ; Kim and Kim, 2020 ; Kim M. et al, 2020 ; Lin et al, 2020 ; Liu and Zhang, 2020 ; Ma J. et al, 2020 ; Ma Q. et al, 2020 ; Niu et al, 2020 ; Qu et al, 2020 ; Sen et al, 2020 ; Song et al, 2020 ; Sun K. et al, 2020 ; Tao et al, 2020 ; Wang S. et al, 2020 ; Wang et al, 2020b ; Ya et al, 2020 ; Yao et al, 2020 ; Zhang et al, 2020b ; Hong et al, 2021 ; Jia et al, 2021 ; Li Y. et al, 2021 ; Lin et al, 2021 ) in the “China Novel Coronavirus Pneumonia Diagnosis and Treatment Program.” Among them, some herbs with potential ACE2-blockers and their related active ingredients are sorted out in Figure 3 . Research results show that the herbs as mentioned above may maintain the balance of RAS-related pathways ( Saranya et al, 2017 ), inhibit the activation of the complement system ( Perez-Roses et al, 2015 ), blunt inflammation ( Kim M. et al, 2020 ; Kim and Kim, 2020 ), participate in immune regulation ( Qu et al, 2020 ), inhibit the activity of SARS-CoV-2 3C-like protease ( Chuan et al, 2020 ; Feng et al, 2020 ; Huang L. et al, 2020 ; Lin et al, 2020 ; Sen et al, 2020 ; Tao et al, 2020 ; Ya et al, 2020 ), and inhibit the binding process of ACE2 ( Hoffmann et al, 2020 ; Ma Q. et al, 2020 ; Niu et al, 2020 ; Song et al, 2020 ; Wang et al, 2020b ).…”
Section: Herbal Medicine Gut Microbiota and Coronavirus Disease 19mentioning
confidence: 99%