Potential Effect of the Presence of Gray Crescent on Analysis of Optic Disc and Retinal Nerve Fiber Layer Defects—Reply

Choi, Jung Sik; Park, Chan Kee

doi:10.1001/jamaophthalmol.2014.5331

Cited by 1 publication

(2 citation statements)

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“…The authors contended that because GCs tended to occur frequently in eyes with large, nontilted optic discs that had large horizontal diameters of the optic disc, they would not alter the results of the association of the ovality index and the bihemispheric RNFL defect. 12 While this is likely true when ovality index is used as a measure of optic disc tilt, when stereoscopically Open access identified tilt is used, it might alter the results, as has been shown in a previous report. 13 This study was performed on Korean eyes where optic disc tilt has been associated with myopic glaucoma.…”

Section: Open Accessmentioning

confidence: 89%

“…On reviewing the optic disc photographs of these 136 patients, GC was found to be present in 23.5% of the eyes examined. The authors contended that because GCs tended to occur frequently in eyes with large, non-tilted optic discs that had large horizontal diameters of the optic disc, they would not alter the results of the association of the ovality index and the bihemispheric RNFL defect 12. While this is likely true when ovality index is used as a measure of optic disc tilt, when stereoscopically identified tilt is used, it might alter the results, as has been shown in a previous report 13.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and factors associated with optic disc grey crescent in the Primary Open-Angle African Ancestry Glaucoma Genetics (POAAGG) Study

et al. 2023

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AimTo investigate the prevalence and factors associated with optic disc grey crescent (GC) in African Americans with glaucoma.MethodsStereo optic disc image features from subjects with glaucoma in the Primary Open-Angle African Ancestry Glaucoma Genetics Study were evaluated independently by non-physician graders and discrepancies adjudicated by an ophthalmologist. Risk factors for GC were evaluated by logistic regression models with intereye correlation accounted for by generalised estimating equations. Adjusted ORs (aORs) were generated.ResultsGC was present in 227 (15%) of 1491 glaucoma cases, with 57 (3.82%) bilateral and 170 (11.4%) unilateral. In multivariable analysis, factors associated with GC were younger age (aOR 1.27, 95% CI 1.11 to 1.43 for every decade younger in age, p=0.001), diabetes (aOR 1.46, 95% CI 1.09 to 1.96, p=0.01), optic disc tilt (aOR 1.84, 95% CI 1.36 to 2.48, p<0.0001), a sloping retinal region adjacent to the outer disc margin (aOR 2.37, 95% CI 1.74 to 3.32, p<0.0001) and beta peripapillary atrophy (aOR 2.32, 95% CI 1.60 to 3.37, p<0.0001). Subjects with GC had a lower mean (SD) value of the ancestral component q0 than those without GC (0.22 (0.15) vs 0.27 (0.20), p=0.001), consistent with higher degrees of African ancestry.ConclusionsMore than 1 in 10 glaucoma cases with African ancestry have GC, occurring more frequently in younger subjects, higher degrees of African ancestry and diabetes. GC was associated with several ocular features, including optic disc tilt and beta peripapillary atrophy. These associations should be considered when evaluating black patients with primary open-angle glaucoma.

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Section: Open Accessmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%