Potential effects of environmental conditions on the efficiency of the antifungal tebuconazole controlling Fusarium verticillioides and Fusarium proliferatum growth rate and fumonisin biosynthesis

Marín, Patricia; Ory, Ana de; Cruz, Alejandra; Magan, Naresh; González-Jaén, M. Teresa

doi:10.1016/j.ijfoodmicro.2013.05.022

Cited by 49 publications

(41 citation statements)

References 40 publications

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“…Similar research performed on Fusarium verticillioides and Fusarium proliferatum strains has shown that sublethal doses of fungicides in combination with mild water stress and temperatures less than 35°C, significantly induced Fum1 expression with slight differences in both species (Marín et al 2013). Analogous studies carried out with different fungicides (tebuconazole and prochloraz) on F. langsethiae revealed an analogous increase of toxin production at low doses of some fungicides with regard to untreated cultures (Mateo et al 2011).…”

Section: Discussionsupporting

confidence: 67%

“…Miguel et al 2015) and secondary metabolite accumulation (e.g. Ochiai et al 2007;Mateo et al 2011;Marín et al 2013). The possible influence on the activity of the biosynthetic genes responsible for the production of mycotoxins can thus affect the efficiency of fungicidal treatments in controlling mycotoxin producers.…”

Section: Discussionmentioning

confidence: 99%

“…However, while results of these inquiries have shown the benefits of optimised timing, the discrepancies between different studies are only rarely investigated in conjunction with molecular studies such as expression profiling of mycotoxin biosynthetic genes under different regimes (e.g. Marín et al 2013) or prediction of regulatory single nucleotide polymorphisms affecting treatment efficiency (e.g. Talas et al 2016).…”

Section: Discussionmentioning

confidence: 99%

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Multiple facets of response to fungicides – the influence of azole treatment on expression of key mycotoxin biosynthetic genes and candidate resistance factors in the control of resistant Fusarium strains

et al. 2016

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The spread of fungicide resistant and/or tolerant phytopathogenic fungi is an important factor affecting crop protection. However, the mechanisms of fungal response to fungicide application are not entirely characterised. In particular, the contribution of previously known resistance factors and the final influence of fungicide treatments on metabolism of surviving mycelia (e.g. mycotoxin increased release and biosynthesis potentially causing contamination of the crops) merit investigation, in order to improve future molecular diagnostics of fungicide resistant strains. The performed experiments have shown distinct expression changes for homologs of a known fungicide resistance factor Flr1 (yeast; DHA1 family of major facilitator superfamily transporters) after azole application in cultured fusaria. Two distantly related homologs of that gene were selected, based on the unsupervised clustering and phylogenetic analysis of transporter sequences. One of these (FGSG_02865), was found to occur across the Fusarium sambucinum complex (F. graminearum, F. culmorum, F. cerealis) and was upregulated starting 24 h after fungicide treatments. This delayed response may point to possible involvement of DHA1 antiporters in a generalised response to stress resulting from fungicide treatment. Additional expression profiling was conducted for the mycotoxin biosynthetic genes (trichothecene and zearalenone gene clusters) in strains of Fusarium sambucinum complex cereal pathogens. The expression changes, when subjected to treatment with the fungicides (flusilazole, carbendazim), show that even an effective treatment (in this study, the benzimidazole fungicide carbendazim) applied to the grown mycelium, can result in enhanced activation of mycotoxin biosynthetic genes in fungal cells which survive the treatment. Our results suggest that increased mycotoxin contamination can be strongly influenced not only by the amount or the type of antifungal compound, but also the timing of fungicide exposition (stage of infection).

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Multiple facets of response to fungicides – the influence of azole treatment on expression of key mycotoxin biosynthetic genes and candidate resistance factors in the control of resistant Fusarium strains

et al. 2016

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“…Chemical syntheses have been achieved for a few bioactive bis-naphtho-γ-pyrones such as ustilaginoidin A (15) [67] and nigerone (55) [68,69]. After comprehensive understanding of biosynthetic pathways of some bis-naphtho-γ-pyrones in the next few years, we can effectively not only increase yields of the bioactive bis-naphtho-γ-pyrones (i.e., cephalochromin, isochaetochromins B 1 and B 2 ), but also prevent biosynthesis of some toxic bis-naphtho-γ-pyrones (i.e., ustilaginoidins A-J) [70]. In addition, the physiological and ecological roles of the bis-naphtho-γ-pyrones in fungi need to be clarified in detail [71,72].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

Tian

Sun

et al. 2014

Molecules

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Bis-naphtho-γ-pyrones are an important group of aromatic polyketides derived from fungi. They have a variety of biological activities including cytotoxic, antitumor, antimicrobial, tyrosine kinase and HIV-1 integrase inhibition properties, demonstrating their potential applications in medicine and agriculture. At least 59 bis-naphtho-γ-pyrones from fungi have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, biosynthesis, and structure, as well as their biological activities. Some considerations regarding to synthesis, production, and medicinal and agricultural applications of bis-naphtho-γ-pyrones are also discussed.

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“…Although literature reviews on the expected impact from climate change on mycotoxin contamination of cereals and other crops are available (Magan et al, 2011;Marín et al, 2013;Marroquín-Cardona et al, 2014;Medina et al, 2014a,b;Miraglia et al, 2009;Ongoma, 2013;Lima, 2010, 2011;Paterson et al, 2014;Tirado et al, 2010;Wu et al, 2011), a limited number of studies quantitatively estimated these impacts. This study reviewed information from these quantitative studies, identified gaps in knowledge and data, and provided recommendations for future studies.…”

Section: Introductionmentioning

confidence: 99%

Modelling climate change impacts on mycotoxin contamination

Fels‐Klerx

Liu

Battilani

2016

WMJ

119

103

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Projected climate change effects will influence primary agricultural systems and thus food security, directly via impacts on yields, and indirectly via impacts on its safety, with mycotoxins considered as crucial hazards. Mycotoxins are produced by a wide variety of fungal species, each having their own characteristics and requirements. The geographic distribution of toxigenic fungi reflects their ecological needs, with thermophilic fungi prevalent at lower latitudes and psychrophiles at the higher latitudes. A resulting gradient of mycotoxin contamination has been repeatedly stressed. Changes in climatic conditions will lead to shifts in the fungal population and the mycotoxin patterns. In general, climate change is expected to increase mycotoxin contamination of crops, but due to the complexity of mycoflora associated to each crop and its interaction with the environment, it appears rash to draw conclusions without specific studies. Very recently first quantitative estimations of impacts of climate change on mycotoxin occurrence have been made. Two studies each applied models of different disciplines including climate projection, crop phenology and fungal/mycotoxin prediction to cereals cultivated in Europe. They were followed by a case study on climate change effects on Alternaria moulds and their mycotoxins in tomato. Results showed that DON contamination of wheat grown in Europe was, in general, expected to increase. However, variation was large, and in some years and some regions a decrease in DON contamination was expected. Regarding aflatoxin contamination of maize grown in Europe, an increase was estimated, mainly in the +2 °C scenario. Two main research gaps were identified related to the (limited) number of existing quantitative models taking into account climate change and their validation in limited areas. Efforts are therefore mandatory to be prepared for future changes and challenges on model validation and limited mycotoxin-crop combinations.

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Potential effects of environmental conditions on the efficiency of the antifungal tebuconazole controlling Fusarium verticillioides and Fusarium proliferatum growth rate and fumonisin biosynthesis

Cited by 49 publications

References 40 publications

Multiple facets of response to fungicides – the influence of azole treatment on expression of key mycotoxin biosynthetic genes and candidate resistance factors in the control of resistant Fusarium strains

Multiple facets of response to fungicides – the influence of azole treatment on expression of key mycotoxin biosynthetic genes and candidate resistance factors in the control of resistant Fusarium strains

Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

Modelling climate change impacts on mycotoxin contamination

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