Potential effects of transdermal nitric oxide donor on fetal growth restriction and oligohydramnios: A case report

Murata, Tsuyoshi; Fukuda, Toma; Sato, Tetsu; Kanno, Aya; Kyozuka, Hyo; Yasuda, Shun; Kin, Shogo; Fujimori, Keiya

doi:10.1002/ccr3.3410

Cited by 1 publication

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“…In addition, in pregnant mice lacking a denitrosylase, S-nitrosoglutathione reductase, vitamin C treatment rescued the maternal PE-like phenotype, including hypertension, proteinuria, renal pathology, cardiac concentric hypertrophy and decreased placental vascularization (38). In humans, several studies have demonstrated that NO donor improved maternal and fetal hemodynamics in PE and FGR (39)(40)(41)(42). However, the current studies are limited due to the small sample size and the observational nature, although they demonstrate the potential effectiveness of antioxidant therapy.…”

Section: Oxidative Stress In Placental Pathologiesmentioning

confidence: 99%

Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney

et al. 2022

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Oxidative stress occurs when there is an imbalance between reactive oxygen species/reactive nitrogen species and antioxidant systems. The interplay between these complex processes is crucial for normal pregnancy and fetal development; however, when oxidative stress predominates, pregnancy related complications and adverse fetal programming such as preterm birth ensues. Understanding how oxidative stress negatively impacts outcomes for the maternal-fetal dyad has allowed for the exploration of antioxidant therapies to prevent and/or mitigate disease progression. In the developing kidney, the negative impact of oxidative stress has also been noted as it relates to the development of hypertension and kidney injury mostly in animal models. Clinical research addressing the implications of oxidative stress in the developing kidney is less developed than that of the neurodevelopmental and respiratory conditions of preterm infants and other vulnerable neonatal groups. Efforts to study the oxidative stress pathway along the continuum of the perinatal period using a team science approach can help to understand the multi-organ dysfunction that the maternal-fetal dyad sustains and guide the investigation of antioxidant therapies to ameliorate the global toxicity. This educational review will provide a comprehensive and multidisciplinary perspective on the impact of oxidative stress during the perinatal period in the development of maternal and fetal/neonatal complications, and implications on developmental programming of accelerated aging and cardiovascular and renal disease for a lifetime.

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Section: Oxidative Stress In Placental Pathologiesmentioning

confidence: 99%

Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney

et al. 2022

View full text Add to dashboard Cite

show abstract

Potential effects of transdermal nitric oxide donor on fetal growth restriction and oligohydramnios: A case report

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 1 publication

References 24 publications

Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney

Educational Review: The Impact of Perinatal Oxidative Stress on the Developing Kidney

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