Potential efficacy of Coenzyme Q10 against oxytetracycline-induced hepatorenal and reproductive toxicity in male rats

Abstract

This study was performed to assess potential efficacy of Coenzyme Q10 (CoQ10) to restore oxytetracycline (OXT)-induced toxicity. Rats were distributed into four equal groups (6 each). The Control group received propylene glycol (0.5 ml p.o). CoQ10 group received Coenzyme Q10 (10 mg/kg BW p.o). OXT group (rats were injected intraperitoneally with 200 mg/kg BW oxytetracycline hydrochloride). OXT+CoQ10 group (rats were given the combined treatments). Treatments were used daily for seven days. Results indicated that OXT induced significant changes in serum biochemical parameters, significant increase of lipid peroxidation and exhaustion of reduced glutathione and catalase in liver, kidney and testis. Also, OXT reduced serum testosterone levels besides sperm motility and viability. Histopathological changes were marked in liver, kidney and to some extent in testis and epididymis. CoQ10 treatment restored oxidative stress in liver, kidney and testis, improved serum testosterone levels, sperm motility/viability as well as histopathological alterations. In conclusion, short-term administration of OXT induced hepatorenal and male reproductive toxicity through oxidative stress. This study is the first to suggest that CoQ10 could provide partial protection against OXT-induced hepatorenal/reproductive toxicity in male rats.

Protective Potential of Ginseng and/or Coenzyme Q10 on Doxorubicin-induced Testicular and Hepatic Toxicity in Rats

“…Treatment of rats with CoQ10 revealed a significant increase in serum testosterone and testis index value when compared with the DOX group. Oda et al stated that supplementation of CoQ10 to oxytetracyclinetreated rats showed elevated serum levels of testosterone and restored relative testis weight [25]. Furthermore, CoQ10 as an antioxidant suppressed lipid peroxidation in testis.…”