Potential for biodegradation and sorption of acetaminophen, caffeine, propranolol and acebutolol in lab-scale aqueous environments

Lin, Angela Yu-Chen; Lin, Chih-Ann; Tung, Hsin Hsin; Chary, N.S.

doi:10.1016/j.jhazmat.2010.07.017

Cited by 155 publications

(53 citation statements)

References 35 publications

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“…Besides this, sorption onto suspended particulate matter or sediments can occur. High distribution coefficients (k d ) were observed in other studies for CAF (17.9-250 L kg −1 ), ATN (8.1 L kg −1 ), and NPX (1.9 L kg −1 ), although for PAR sorption is reported to be negligible (k d 0.5-2.8 L kg −1 ) (Lin et al 2010;Martínez-Hernández et al 2014;Yamamoto et al 2009). …”

Section: Spatiotemporal Distributionmentioning

confidence: 72%

A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil

Campanha

Awan

Sousa

et al. 2014

Environ Sci Pollut Res

157

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This manuscript reports a 3-year study on occurrence of pharmaceuticals, hormones, and triclosan in surface waters of a central urban region of São Paulo State of Southeast Brazil (the Monjolinho River in São Carlos). Water samples collected once at every 2 months were pre-concentrated by solid-phase extraction (SPE) and analyzed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). The most frequently detected compounds in higher concentrations were caffeine, paracetamol, and atenolol (maximum concentrations 129,585, 30,421, and 8199 ng L(-1), respectively), while hormones estrone and 17-β-estradiol were the least detected, in levels up to 14.8 ng L(-1). There was an increasing trend in concentrations of most of the compounds along the river course, especially downstream of the river where there is discharge of both wastewater treatment plant effluent and raw sewage from a particular region of São Carlos city. Concentrations of contaminants were higher during dry periods as a result of decline in the water levels. Decrease in concentrations near the river mouth occurred to different extents for each compound. It was high for caffeine and atenolol, but was very low for carbamazepine and diclofenac. The present study reports the first data about the occurrence of some major emerging contaminants in the Monjolinho River. Besides its regional significance, this work may assist in composing a dataset for water contamination diagnosis focusing on emerging contaminants, both in the Brazilian as well as in the Global studies related to aquatic ecosystems. Such datasets can be helpful for making future public policies on water quality, since these compounds are not yet legally regulated.

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Section: Spatiotemporal Distributionmentioning

confidence: 72%

A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil

Campanha

Awan

Sousa

et al. 2014

Environ Sci Pollut Res

157

View full text Add to dashboard Cite

show abstract

“…For example, pharmaceuticals in STP influent can be removed by membrane bioreactor and activated sludge processes (Jones et al, 2007;De Gusseme et al, 2011), while ultraviolet (UV) treatment, used for disinfecting polluted water, has also been reported to remove pharmaceuticals as a result of UV-induced photodegradation and transformation into other compounds (Maquille et al, 2010;Tong et al, 2011). Other reports indicate that pharmaceuticals can be removed from the aquatic environment in various ways, including sorption, biodegradation and photodegradation in sunlight (Teeter and Meyerhoff, 2002;Yamamoto et al, 2009;Ioele et al, 2010;Lin et al, 2010). However, they are not necessarily inactivated or removed completely, and some persist in the aquatic environment.…”

Section: Introductionmentioning

confidence: 99%

Photodegradation of pharmaceuticals in the aquatic environment by sunlight and UV-A, -B and -C irradiation

et al. 2013

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-In order to investigate the effect of sunlight on the persistence and ecotoxicity of pharmaceuticals contaminating the aquatic environment, we exposed nine pharmaceuticals (acetaminophen (AA), amiodarone (AM), dapsone (DP), dexamethasone (DX), indomethacin (IM), naproxen (NP), phenytoin (PH), raloxifene (RL), and sulindac (SL)) in aqueous media to sunlight and to ultraviolet (UV) irradiation at 254, 302 or 365 nm (UV-C, UV-B or UV-A, respectively). Degradation of the pharmaceuticals was monitored by means of high-performance liquid chromatography (HPLC). Sunlight completely degraded AM, DP and DX within 6 hr, and partly degraded the other pharmaceuticals, except AA and PH, which were not degraded. Similar results were obtained with UV-B, while UV-A was less effective (both UV-A and -B are components of sunlight). All the pharmaceuticals were photodegraded by UV-C, which is used for sterilization in sewage treatment plants. Thus, the photodegradation rates of pharmaceuticals are dependent on both chemical structure and the wavelength of UV exposure. Toxicity assay using the luminescent bacteria test (ISO11348) indicated that UV irradiation reduced the toxicity of some pharmaceuticals to aquatic organisms by decreasing their amount (photodegradation) and increased the toxicity of others by generating toxic photoproduct(s). These results indicate the importance of investigating not only parent compounds, but also photoproducts in the risk assessment of pharmaceuticals in aquatic environments.

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“…APAP is a broadly used analgesic, antipyretic drug that relieves fever, headache, and minor aches (Lin et al 2010). In 2000, it was ranked as one of the top three drugs prescribed in the United Kingdom (Zhang et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Zero-valent iron/persulfate(Fe0/PS) oxidation acetaminophen in water

Deng

Shao

Gao

et al. 2013

Int. J. Environ. Sci. Technol.

100

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Potential for biodegradation and sorption of acetaminophen, caffeine, propranolol and acebutolol in lab-scale aqueous environments

Cited by 155 publications

References 35 publications

A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil

A 3-year study on occurrence of emerging contaminants in an urban stream of São Paulo State of Southeast Brazil

Photodegradation of pharmaceuticals in the aquatic environment by sunlight and UV-A, -B and -C irradiation

Zero-valent iron/persulfate(Fe0/PS) oxidation acetaminophen in water

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