Potential for Discovery of Neuroprotective Factors in Serum and Tissue from Hibernating Species

Ross, Austin P.; Drew, Kelly L.

doi:10.2174/138955706777934964

Cited by 5 publications

(4 citation statements)

References 133 publications

(126 reference statements)

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“…The physiological changes associated with metabolic depression (respiratory depression, bradycardia, hypophagia, cessation of renal function) are life-threatening conditions in non-dormant animals. For example, during hibernation breathing and blood perfusion levels fall to those equivalent to what occurs during severe organ ischemia and hypoxia in the euthermic state, which includes a reduction in cerebral perfusion of up to 90% (Eddy et al, 2005;Ross and Drew, 2006). Such a significant decrease in oxygen supply to the tissues during the euthermic state would result in a significant drop in ATP-production but the need for ATP (e.g.…”

Section: Dormancy and Metabolic Depressionmentioning

confidence: 99%

“…to maintain ion gradients) would remain high, resulting in an energy deficit. This mis-match in energy balance would eventually lead to the breakdown of cell homeostasis and membrane potential, ultimately resulting in cell death (Ross and Drew, 2006). However, during metabolic depression, energy balance is maintained by coordinating the shut down of ATP-producing and ATP-consuming processes, matching demand with supply (Drew et al, 2007;Ross and Drew, 2006).…”

Section: Dormancy and Metabolic Depressionmentioning

confidence: 99%

“…This mis-match in energy balance would eventually lead to the breakdown of cell homeostasis and membrane potential, ultimately resulting in cell death (Ross and Drew, 2006). However, during metabolic depression, energy balance is maintained by coordinating the shut down of ATP-producing and ATP-consuming processes, matching demand with supply (Drew et al, 2007;Ross and Drew, 2006). Thus metabolic depression is a highly regulated and reversible process; however the mechanism(s) involved in regulating metabolic depression remain poorly understood.…”

Section: Dormancy and Metabolic Depressionmentioning

confidence: 99%

“…The physiological changes associated with metabolic depression are drastic and potentially life threatening. For example, during the torpid stages of hibernation breathing and blood perfusion levels fall to those equivalent to severe organ ischemia and hypoxia in the euthermic state (Eddy et al, 2005;Ross and Drew, 2006). When ATP production is disrupted due to a decrease in oxygen availability, cellular ATP levels quickly drop and ATP-dependent ion pumps can no longer keep pace with the opposing passive flow of ions.…”

Section: Regulating Processesmentioning

confidence: 99%

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Metabolic depression in Cyclorana alboguttata and the potential role of the endogenous opioid system and thyroid axis as regulators of aestivation

Kayes¹

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This thesis is composed of my original work, and contains no material previously published or written by another person except where due reference has been made in the text. I have clearly stated the contribution by others to jointly-authored works that I have included in my thesis.I have clearly stated the contribution of others to my thesis as a whole, including statistical assistance, survey design, data analysis, significant technical procedures, professional editorial advice, and any other original research work used or reported in my thesis. The content of my thesis is the result of work I have carried out since the commencement of my research higher degree candidature and does not include a substantial part of work that has been submitted to qualify for the award of any other degree or diploma in any university or other tertiary institution. I have clearly stated which parts of my thesis, if any, have been submitted to qualify for another award. I acknowledge that an electronic copy of my thesis must be lodged with the University Library and, subject to the General Award Rules of The University of Queensland, immediately made available for research and study in accordance with the Copyright Act 1968. I acknowledge that copyright of all material contained in my thesis resides with the copyright holder(s) of that material.

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Section: Dormancy and Metabolic Depressionmentioning

confidence: 99%

Section: Dormancy and Metabolic Depressionmentioning

confidence: 99%

Section: Dormancy and Metabolic Depressionmentioning

confidence: 99%

Section: Regulating Processesmentioning

confidence: 99%

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Metabolic depression in Cyclorana alboguttata and the potential role of the endogenous opioid system and thyroid axis as regulators of aestivation

Kayes¹

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The Hibernation-Related Peptide TSKY Acts as a Neuroprotector in Cultured Pond Snail Neurons

Крамарова

Ivlicheva

Ziganshin

et al. 2012

Living in a Seasonal World

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Modifications of the axon initial segment during the hibernation of the Syrian hamster

et al. 2018

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Mammalian hibernation is a natural process in which the brain undergoes profound adaptive changes that appear to protect the brain from extreme hypoxia and hypothermia. In addition to a virtual cessation of neural and metabolic activity, these changes include a decrease in adult neurogenesis; the retraction of neuronal dendritic trees; changes in dendritic spines and synaptic connections; fragmentation of the Golgi apparatus; and the phosphorylation of the microtubule-associated protein tau. Furthermore, alterations of microglial cells also occur in torpor. Importantly, all of these changes are rapidly and fully reversed when the animals arouse from torpor state, with no apparent brain damage occurring. Thus, hibernating animals are excellent natural models to study different aspects of brain plasticity. The axon initial segment (AIS) is critical for the initiation of action potentials in neurons and is an efficient site for the regulation of neural activity. This specialized structure-characterized by the expression of different types of ion channels and adhesion, scaffolding and cytoskeleton proteins-is subjected to morpho-functional plastic changes upon variations in neural activity or in pathological conditions. Here, we used immunocytochemistry and 3D confocal microscopy reconstruction techniques to measure the possible morphological differences in the AIS of neocortical (layers II-III and V) and hippocampal (CA1) neurons during the hibernation of the Syrian hamster. Our results indicate that the general integrity of the AIS is resistant to the ischemia/hypoxia conditions that are characteristic of the torpor phase of hibernation. In addition, the length of the AIS significantly increased in all the regions studied-by about 16-20% in torpor animals compared to controls, suggesting the existence of compensatory mechanisms in response to a decrease in neuronal activity during the torpor phase of hibernation. Furthermore, in double-labeling experiment, we found that the AIS in layer V of torpid animals was longer in neurons expressing phospho-tau than in those not labeled for phospho-tau. This suggests that AIS plastic changes were more marked in phospho-tau accumulating neurons. Overall, the results further emphasize that mammalian hibernation is a good physiological model to study AIS plasticity mechanisms in non-pathological conditions.

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Potential for Discovery of Neuroprotective Factors in Serum and Tissue from Hibernating Species

Cited by 5 publications

References 133 publications

Metabolic depression in Cyclorana alboguttata and the potential role of the endogenous opioid system and thyroid axis as regulators of aestivation

Metabolic depression in Cyclorana alboguttata and the potential role of the endogenous opioid system and thyroid axis as regulators of aestivation

The Hibernation-Related Peptide TSKY Acts as a Neuroprotector in Cultured Pond Snail Neurons

Modifications of the axon initial segment during the hibernation of the Syrian hamster

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