Potential for increased prevalence of neuropathic pain after the COVID-19 pandemic

Attal, Nadine; Martinez, Valéria; Bouhassira, Didier

doi:10.1097/pr9.0000000000000884

Cited by 85 publications

(94 citation statements)

References 70 publications

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“…Так, N. Attal и соавт. [41] провели анализ состояния 50 пациентов с полиневропатией, радикулопатией, травмой спинного мозга и перенесенным инсультом, заболевших COVID-19. 49 из них перенесли инфекцию SARS-CoV-2 достаточно легко, и лишь 1 пациент погиб вследствие респираторных осложнений.…”

Section: клинические проявления пкс: утомляемость и больunclassified

“Post-COVID syndrome”: The focus is on musculoskeletal pain

Каратеев¹,

Амирджанова²,

Насонов

et al. 2021

Naučno-praktičeskaâ revmatologiâ

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Combating the consequences of COVID-19, a disease caused by the new coronavirus infection SARS-CoV-2, is a serious and very urgent task facing modern medicine. COVID-19 often has a severe course and is accompanied by multiple organ damage, systemic immune inflammation, coagulopathy, neuroendocrine and metabolic disorders. Even with a relatively favorable course, the consequences of SARS-CoV-2 infection can be degenerative changes in many organs (pulmonary fibrosis, cardiosclerosis), various functional and psychoemotional disorders. As a result, in 10–50% of patients, various unpleasant symptoms persist for a long time after the acute manifestations of COVID-19 subside and the virus is eliminated. This pathology is referred to as “post-COVID syndrome” (PCS). The main elements of PCS are chronic pain, fatigue, and psychoemotional problems. Functional disorders, autoimmune processes, and severe psychological distress after COVID-19 can cause the development and exacerbation of diseases characterized by chronic pain and fatigue, such as fibromyalgia and chronic fatigue syndrome. Therapy and prevention of PCS include correction of functional disorders, pain control, and consistent physical, psychological, and social rehabilitation.

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Section: клинические проявления пкс: утомляемость и больunclassified

“Post-COVID syndrome”: The focus is on musculoskeletal pain

Каратеев¹,

Амирджанова²,

Насонов

et al. 2021

Naučno-praktičeskaâ revmatologiâ

View full text Add to dashboard Cite

show abstract

“…Peripheral nerve trauma, post herpetic neuralgia, spinal cord injury, traumatic brain injury, stroke and neuropathies associated with chemotherapy, diabetes or HIV infection can give rise to intractable neuropathic pain (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Neuropathic components also contribute to pain associated with COVID-19, multiple sclerosis, fibromyalgia, migraine, osteoarthritis, rheumatoid arthritis, autoimmune disease, and complex regional pain syndromes (14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Although the signs and symptoms of neuropathic pain are similar in males and females, it is now well-established that the underlying cellular mechanisms are very different (24)(25)(26)(27)(28)(29)(30)(31)(32)(33).…”

Section: Introductionmentioning

confidence: 99%

Mediators of Neuropathic Pain; Focus on Spinal Microglia, CSF-1, BDNF, CCL21, TNF-α, Wnt Ligands, and Interleukin 1β

2021

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Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann cells, mast cells, fibroblasts, keratinocytes and epithelial cells are activated leading to the generation of an “inflammatory soup” containing cytokines, chemokines and growth factors. These primary mediators sensitize sensory nerve endings, attract macrophages, neutrophils and lymphocytes, alter gene expression, promote post-translational modification of proteins, and alter ion channel function in primary afferent neurons. This leads to increased excitability and spontaneous activity and the generation of secondary mediators including colony stimulating factor 1 (CSF-1), chemokine C-C motif ligand 21 (CCL-21), Wnt3a, and Wnt5a. Release of these mediators from primary afferent neurons alters the properties of spinal microglial cells causing them to release tertiary mediators, in many situations via ATP-dependent mechanisms. Tertiary mediators such as BDNF, tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and other Wnt ligands facilitate the generation and transmission of nociceptive information by increasing excitatory glutamatergic transmission and attenuating inhibitory GABA and glycinergic transmission in the spinal dorsal horn. This review focusses on activation of microglia by secondary mediators, release of tertiary mediators from microglia and a description of their actions in the spinal dorsal horn. Attention is drawn to the substantial differences in the precise roles of various mediators in males compared to females. At least 25 different mediators have been identified but the similarity of their actions at sensory nerve endings, in the dorsal root ganglia and in the spinal cord means there is considerable redundancy in the available mechanisms. Despite this, behavioral studies show that interruption of the actions of any single mediator can relieve signs of pain in experimental animals. We draw attention this paradox. It is difficult to explain how inactivation of one mediator can relieve pain when so many parallel pathways are available.

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“…Although social isolation may have provided opportunities for some, such as increased time with the family, for others, it has been a significant threat to their quality of life and wellbeing [18] The findings from this study can be used to inform policy and specific responses for future COVID-19 waves, and new future pandemics. This is particularly important as new waves are already swamping some world regions, and an increase in chronic pain after the COVID-19 pandemic is expected [49,50].…”

Section: Discussionmentioning

confidence: 99%

Effects of COVID-19 Social Distancing Measures in Individuals with Chronic Pain Living in Spain in the Late Stages of the Lockdown

Miró

Sánchez‐Rodríguez

Ferreira-Valente

et al. 2021

IJERPH

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Social distancing measures during the lockdown have had a negative impact on chronic pain patients’ function. Research, however, has only focused on the early stages of the first lockdowns. The aim of this study was to improve the understanding of the effects of COVID-19 social distancing measures on individuals with chronic pain living in Spain during the late stages of the lockdown. A group of 361 adults with pain participated in this study. They responded to an online survey and provided information on sociodemographic issues, pain, fatigue, perceived health, and quality of life. The data showed that most participants suffered moderate to severe pain and interferences with pain treatment and an increase in pain intensity during the lockdown. Most participants also informed us that fatigue had worsened during the lockdown (62%). Importantly, females with lower monthly family income and lower education have been found to be associated with greater levels of pain and fatigue. Despite this, participants perceived themselves as having good health and good quality of life. The findings from this study can be used to inform policy and specific responses for future COVID-19 waves and future pandemics where social distancing measures must be implemented.

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Potential for increased prevalence of neuropathic pain after the COVID-19 pandemic

Cited by 85 publications

References 70 publications

“Post-COVID syndrome”: The focus is on musculoskeletal pain

“Post-COVID syndrome”: The focus is on musculoskeletal pain

Mediators of Neuropathic Pain; Focus on Spinal Microglia, CSF-1, BDNF, CCL21, TNF-α, Wnt Ligands, and Interleukin 1β

Effects of COVID-19 Social Distancing Measures in Individuals with Chronic Pain Living in Spain in the Late Stages of the Lockdown

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