Potential for simplification of HIV treatment with boosted protease inhibitor monotherapy

Reina, Elena Acedo; Miguel, Ramón San; Larrea, Natalia; García, Patricia; Napal, Víctor

doi:10.1007/s11096-012-9692-5

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…On the other hand, the average yearly cost in Spain per patient under triple antiretroviral treatment was estimated at 8.100 euros in 2011 20 , while the yearly cost per OAT patients under MT or B/N therapy was estimated at 1.041 euros (MT) and 1.050 euros (B/N) in 2010 21 . Through comparison between the different treatment's yearly costs, the economical, human and healthcare benefit of HIV infection prevention becomes apparent.…”

Section: Oat Advantagesmentioning

confidence: 99%

¿Es necesario disponer de tratamientos con buprenorfina/naloxona para los presos dependientes de opiáceos?

Marco¹,

López-Burgos²,

García‐Marcos³

et al. 2013

Rev. esp. sanid. penit.

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Agonist therapy (OAT) programs in combination with a psychosocial approach are the most effective way to prevent relapse in opioid-dependent patients. These programs reduce morbidity and risk behaviours for HIV transmission and other infections, improve quality of life and retention in treatment, and have a positive impact on antisocial behaviour. They are therefore very useful for prisoners with a history of opiate use. OATs based on buprenorphine/naloxone (B/N), along with others using methadone, are currently available in Spain. Diversified treatment offers an alternative treatment for opioid dependence that is more personalized and tailored to the patient's characteristics. As regards effectiveness, both drugs are very similar, but B/N shows a better safety profile and fewer drug-drug interactions and can be dispensed in pharmacies once the patient is released, which can assist with the patient' social reintegration. B/N treatment is more expensive than methadone. It is advisable to have different modes of OAT. These should be prescribed according to the characteristics and needs of each case, without incarceration impeding the right to drug treatment, which should be similar to that performed outside prison.

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Section: Oat Advantagesmentioning

confidence: 99%

¿Es necesario disponer de tratamientos con buprenorfina/naloxona para los presos dependientes de opiáceos?

Marco¹,

López-Burgos²,

García‐Marcos³

et al. 2013

Rev. esp. sanid. penit.

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“…However, for some patients, there are often important, nonvirologic reasons to modify their antiretroviral regimen, such as for drug intolerance or the need to simplify the regimen. 2 – 4 The perspective of long-term therapy and the availability of a high number of drugs with different toxicities and manageability favors a tailor-made therapeutic course, aimed to ensure consistent virological suppression and also improve quality of life for the patients. In Italian guidelines, this strategy is called “antiretroviral therapy (ART) optimization.”…”

Section: Introductionmentioning

confidence: 99%

Budget impact analysis of antiretroviral less drug regimen simplification in HIV-positive patients on the Italian National Health Service

Restelli¹,

Andreoni²,

Antinori³

et al. 2014

CEOR

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BackgroundDeintensification and less drug regimen (LDR) antiretroviral therapy (ART) strategies have proved to be effective in terms of maintaining viral suppression in human immunodeficiency virus (HIV)-positive patients, increasing tolerability, and reducing toxicity of antiretroviral drugs administered to patients. However, the economic impact of these strategies have not been widely investigated. The aim of the study is to evaluate the economic impact that ART LDR could have on the Italian National Health Service (INHS) budget.MethodsA budget impact model was structured to assess the potential savings for the INHS by the use of ART LDR for HIV-positive patients with a 3 year perspective. Data concerning ART cost, patient distribution within different ARTs, and probabilities for patients to change ART on a yearly basis were collected within four Italian infectious diseases departments, providing ART to 13.7% of the total number of patients receiving ART in Italy.ResultsThe LDR investigated (protease inhibitor-based dual and monotherapies) led to savings for the hospitals involved when compared to the “do nothing” scenario on a 3 year basis, between 6.7% (23.11 million €) and 12.8% (44.32 million €) of the total ART expenditures. The mean yearly cost per patient is reduced from 9,875 € in the do nothing scenario to a range between 9,218 € and 8,615 €. The use of these strategies within the four departments involved would have led to a reduction of ART expenditures for the INHS of between 1.1% and 2.1% in 3 years.ConclusionART LDR simplification would have a significant impact in the reduction of ART-related costs within the hospitals involved in the study. These strategies could therefore be addressed as a sustainable answer to the public financing reduction observed within the INHS in the last year, allowing therapies to be dispensed without affecting the quality of the services provided.

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Impacto económico asociado a la implementación de las recomendaciones con grado de evidencia A- I del documento de consenso de GeSIDA/PNS (2015) relativas a la optimización del tratamiento antirretroviral en adultos infectados por virus de la inmunodeficiencia humana con carga viral suprimida en España

Ribera

Martínez-Sesmero

Ferrández

et al. 2018

Enfermedades Infecciosas y Microbiología Clínica

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Potential for simplification of HIV treatment with boosted protease inhibitor monotherapy

Cited by 4 publications

References 24 publications

¿Es necesario disponer de tratamientos con buprenorfina/naloxona para los presos dependientes de opiáceos?

¿Es necesario disponer de tratamientos con buprenorfina/naloxona para los presos dependientes de opiáceos?

Budget impact analysis of antiretroviral less drug regimen simplification in HIV-positive patients on the Italian National Health Service

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