Potential forensic markers from synthetic pathways to 1-phenyl-2-propanone from uncontrolled and controlled substances

Interpol Review of Drug Analysis 2019-2022

“…2019 Analysis of aerosolized methylamphetamine from e-cigarettes using SPME-DART-HRMS and SPME-GC-MS [ 162 ]; fluorescent nanosensor for detection of methylamphetamine [ 163 ]; supercritical fluid chromatography-tandem mass spectrometry method could be a powerful analytical tool for methylamphetamine impurity profiling [ 164 ]; 2020 a novel fluorescent nanosensor based on graphene quantum dots embedded within molecularly imprinted polymer was developed for detection and determination of methylamphetamine [ 165 ]; chemosensor for detection of MA [ 166 ]; determination of the stereoisomeric distribution of R-(−)- and S-(+)-MA using HPLC-MS and GC-MS [ 167 ]; use of IRMS alongside conventional chemical profiling techniques to investigate whether methylamphetamine samples of differing P2P origins can be distinguished through drug profiling [ 168 ]; smartphone-based device for rapid on-site MA detection [ 169 ]; fluorescent drug detection device based on LED induction (FD-LED) for MA [ 170 ]; NIR-PLS quantitative modelfor seven adulterants with MA purity ranging from 10% to 100%, [ 171 ]; fluorescent nanosensor for detection of MA [ 172 ]; 2021 fluorescence resonance energy transfer-thermal lens spectrometry (FRET-TLS) for the determination of MA [ 173 ]; H-1 NMR method for discrimination of the enantiomers of MA from ephedrine and pseudoephedrine using chiral solvents [ 174 ]; review of the optical and electrochemical sensors used to date for MA detection in seized and biological samples [ 175 ]; development of an IMS method to detect MA using pyridine as a dopant in the presence of nicotine [ 176 ]; development and validation of a modified LC-ESI-MS/MS method for the simultaneous determination of MA and its isomer N-isopropylbenzylamine (N-IBA) in forensic samples [ 177 ]; SERS method for detection of MA [ 178 , 179 ]; investigation of the reaction mechanisms of three different synthesis methods (Nagai, Hypo, and Moscow) for MA [ 180 ]; establishment of likelihood ration models to evaluate the cause of MA contamination resulting from either use or clandestine manufacturing [ 181 ]; 2022 study of forensic markers of 1-phenyl-2-propanone synthetic pathways for identification of precoursors to methamphetamine [ 182 ]; impurity profiling of MA synthesized from alpha-phenylacetoacetonitrile (APAAN) including the identification of five new impurities and two previously identified impurities [ 183 ]; investigation of the use of stable isotope ratio mass spectrometry (IRMS) to determine the precursor and precursor origin of MA drug samples [ 184 ]; development of an electrochemical detection technique to determine the residual methamphetamine contamination on household surfaces [ 1...…”

Determination of Methamphetamine by High-Performance Liquid Chromatography in Odor-Adsorbent Material Used for Training Drug-Detection Animals

“…In order to prevent the widespread distribution and abuse of methamphetamine, various techniques have been developed for the detection of methamphetamine, including liquid chromatography (LC) [ 23 ], gas chromatography (GC) [ 24 ], capillary electrophoresis [ 25 ], immunoassays [ 26 ], mass spectrometry (MS), and molecularly imprinted polymer solid-phase extraction [ 27 ]. Detection methods for methamphetamine have been changing rapidly in recent years, as recorded in the “Interpol Review of Drug Analysis 2019–2022” [ 28 ]; fluorescent nanosensors and the supercritical fluid chromatography–tandem mass spectrometry method were, respectively, used to conduct methamphetamine and methylamphetamine impurity profiling in 2019; in 2020, novel fluorescent nanosensors based on graphene quantum dots in molecularly imprinted polymers were found to be powerful tools for methamphetamine analysis [ 29 ]; and in 2022, forensic markers of the 1-phenyl-2-propanone synthesis pathway were investigated to identify precursors to methamphetamine [ 30 ].…”