2019
DOI: 10.1007/s11684-019-0701-0
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Potential functions of esophageal cancer-related gene-4 in the cardiovascular system

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Cited by 6 publications
(17 citation statements)
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“…Recent research has revealed that ECRG4 expression is quite distinct and is present in esophageal squamous epithelial cells as well as the sinoatrial node, atrioventricular node, atrial and ventricular cells. Additional investigations further concluded that ECRG4 could maintain cardiac homeostasis and regulate cardiac rhythm while it downregulation may contribute to atrial fibrillation (AF) (1). Moreover, ECRG4 is most likely a hypoxic sensor and may be related to myocardial ischemia (1).…”
Section: Introductionmentioning
confidence: 99%
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“…Recent research has revealed that ECRG4 expression is quite distinct and is present in esophageal squamous epithelial cells as well as the sinoatrial node, atrioventricular node, atrial and ventricular cells. Additional investigations further concluded that ECRG4 could maintain cardiac homeostasis and regulate cardiac rhythm while it downregulation may contribute to atrial fibrillation (AF) (1). Moreover, ECRG4 is most likely a hypoxic sensor and may be related to myocardial ischemia (1).…”
Section: Introductionmentioning
confidence: 99%
“…Additional investigations further concluded that ECRG4 could maintain cardiac homeostasis and regulate cardiac rhythm while it downregulation may contribute to atrial fibrillation (AF) (1). Moreover, ECRG4 is most likely a hypoxic sensor and may be related to myocardial ischemia (1). Notably, ECRG4 is also a tumor suppressor gene that can prevent esophageal cancer cell proliferation (2).…”
Section: Introductionmentioning
confidence: 99%
“…O gene Ecrg4, oficialmente chamado de C2orf40 em humanos, está localizado no cromossomo 2q12.2 e consiste de quatro exons, medindo cerca de 14,9 kb e com um cDNA correspondente de 772 pb (Mirabeau et al, 2007;Tadross et al, 2010;Jiang et al, 2013;Porzionato et al, 2015;Qin;Zhou et al, 2019) A ECRG4 contém uma sequência inicial de 30 aminoácidos que funciona como um peptídio sinal e um único sítio putativo de clivagem pró-hormônio, seguido por uma sequência de clivagem para a furina, uma convertase pró-hormônio presente na região intermediária de ECRG4, e um sítio de clivagem de trombina que ocorre próximo da extremidade Cterminal (Figura 3). O processamento de ECRG4 por furina foi relatado como essencial para a inibição da proliferação de células tumorais.…”
Section: Augurinaunclassified
“…O processamento de ECRG4 por furina foi relatado como essencial para a inibição da proliferação de células tumorais. A ECRG4 também contém um domínio de homologia porina/canal ânion seletivo voltagem-dependente (VDAC), um domínio de homologia de ciclo de divisão celular e um promotor de anáfase, indicando envolvimento na permeabilidade da membrana mitocondrial e ciclo celular (Dang et al, 2012;Porzionato et al, 2015;Podvin et al, 2016;Qin;Morigushi et al, 2018;Zhou et al, 2019).…”
Section: Augurinaunclassified
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