Potential Health Benefits of Citrus: An Overview

Patil, Bhimanagouda S.; Brodbelt, Jennifer S.; Miller, Edward G.; Turner, Nancy D.

doi:10.1021/bk-2006-0936.ch001

Cited by 15 publications

(14 citation statements)

References 61 publications

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“…[62]. Nomilin (2) exhibited the highest inhibition of p38 MAP kinase activity, followed by limonin (1), deacetylnomilin (4), and defurannomilin (36). Furthermore, TNF-α induced p38 MAP kinase activity in the smooth muscle cells was shown to be completely inhibited by 2.…”

Section: Larvicidal and Insecticidal Activitiesmentioning

confidence: 98%

“…Newly isolated limonoids will be reported and a wide (but not exhaustive) overview on recent findings concerning limonoid bioactivity will be given. Further references focusing on limonoid biological activities may be found in several excellent previous reviews [1,15,[29][30][31][32][33][34][35][36]. Most of the references reviewed herein derive from Reaxys database.…”

Section: Complexity and Evolution Of Citrus Limonoid Researchmentioning

confidence: 99%

“…Both compounds were about twice as potent as 1 in the aromatase inhibition assay. Incidentally, defuranlimonin (35, a limonin analogue with a carboxyl group appended at the C-17 position in lieu of the furan ring; Figure 6) was as active as 1 while defuran nomilin (36) was about six times more potent than 2. A similar trend was observed when studying the effect of CLs on biofilm formation in E. coli where 33, 34, and 35 were more active than 1 [63].…”

Section: 2mentioning

confidence: 99%

“…Advanced complementary analytical methods included tandem MS (MS/MS), liquid chromatography/electrospray ionization MS (LC-ESI-MS), atmospheric pressure chemical ionization MS (APCI-MS), and collisionally activated dissociation (CAD) MS/MS. These techniques have been well reviewed in the earlier literature [1,36,[147][148][149]. In this section, we focus on the isolation and identification of both new and known limonoids by using improved techniques and/or from varieties of Citrus never investigated until that time.…”

Section: Isolation and Identification Of Limonoids From The Citrus Genusmentioning

confidence: 99%

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The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

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Section: Larvicidal and Insecticidal Activitiesmentioning

confidence: 98%

Section: Complexity and Evolution Of Citrus Limonoid Researchmentioning

confidence: 99%

Section: 2mentioning

confidence: 99%

Section: Isolation and Identification Of Limonoids From The Citrus Genusmentioning

confidence: 99%

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The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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“…Limonoids constitute one of the major phytochemicals in citrus, along with flavonoids, coumarins, and carotenoids. However, recent research has discovered the various health benefits and pharmacological uses of limonoids, such as antibacterial, antifungal, antiviral, antioxidant, and anticancer activities (40)(41)(42). Limonoids also exhibited anti-HIV, moderate radical scavenging, and anti-oxidant activities (43,44).…”

Section: Quantitative Measurement Of Purity Of Phytochemical-loaded Nmentioning

confidence: 99%

Quantification of Health-Promoting Compounds by Quantitative¹HNMR Spectroscopy

Jayaprakasha

2014

ACS Symposium Series

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Nuclear magnetic resonance (NMR) spectroscopy is a wellknown analytical technique for simultaneous quantitation and structural elucidation of small molecules and macromolecules. In natural products research, quantitative NMR (qNMR) gives valuable information on metabolites. qNMR is robust with high precision, good reproducibility and is non-destructive, compared to traditional analytical methods. It has proven to be rapid, highly reliable for the determination of purity, examination of impurities, metabolic profiling, and for the quantitation of single entities in complex mixtures without fractionation or isolation. Therefore, qNMR can be used to simultaneously identify and quantify multiple metabolites. This chapter discusses current challenges in quantitation, metabolomics, and sample preparation, as well as the selection of references for quantitation of health-promoting compounds.

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Influence of storage temperature and low‐temperature conditioning on the levels of health‐promoting compounds in Rio Red grapefruit

Chaudhary

Jayaprakasha

2016

Food Science & Nutrition

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Commercial operations use low‐temperature conditioning of citrus fruits to reduce the incidence of chilling injury (CI) during cold storage and quarantine treatments. Rio Red grapefruits (Citrus paradisi Macf) were stored for 12 weeks at 11°C or 5°C; an additional set was temperature conditioned at 16°C for 7 days before storing at 5°C (CD). Every 3 weeks, samples were assessed for chilling injury (CI) and health‐promoting compounds such as ascorbic acid, carotenoids, limonoids, flavonoids, and furocoumarins. Low‐temperature conditioning significantly reduced CI but did not affect the total soluble solids, acidity, and ripening ratio. After 12 weeks of storage, grapefruits showed no significant differences in lycopene, narirutin, poncirin, furocoumarins, and radical scavenging activity in all the three treatments. Limonin was significantly higher (p < .05) in CD fruits, nomilin was significantly higher in fruits stored at 11°C, whereas fruits stored at 5°C had lower levels of naringin, neohesperidin, and didymin after 12 weeks of storage. Low‐temperature conditioning treatment helped fruits to retain similar or higher levels of most of the health‐promoting compounds by the end of storage period while maintaining better quality than the nonconditioned fruits.

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Potential Health Benefits of Citrus: An Overview

Cited by 15 publications

References 61 publications

The Chemistry and Pharmacology of Citrus Limonoids

The Chemistry and Pharmacology of Citrus Limonoids

Quantification of Health-Promoting Compounds by Quantitative¹HNMR Spectroscopy

Influence of storage temperature and low‐temperature conditioning on the levels of health‐promoting compounds in Rio Red grapefruit

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Potential Health Benefits of Citrus: An Overview

Cited by 15 publications

References 61 publications

The Chemistry and Pharmacology of Citrus Limonoids

The Chemistry and Pharmacology of Citrus Limonoids

Quantification of Health-Promoting Compounds by Quantitative1HNMR Spectroscopy

Influence of storage temperature and low‐temperature conditioning on the levels of health‐promoting compounds in Rio Red grapefruit

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Quantification of Health-Promoting Compounds by Quantitative¹HNMR Spectroscopy