Potential Health Benefits of Rhubarb

Clementi, Elisabetta M.; Misiti, Francesco

doi:10.1016/b978-0-12-374628-3.00027-x

Cited by 13 publications

(12 citation statements)

References 82 publications

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“…Rheum officinale , also known as Chinese rhubarb, is one of the best known traditional herbal medicines with pharmacological activities. Extracts from the roots of Rheum officinale have strong antibacterial [265], antioxidative [266], anti-inflammatory [267], and haemostatic [268] effects, validating its widespread use for constipation, chronic liver and kidney diseases [265, 269], and skin lesions [270]. Using a rat excisional wound model, Tang et al found healing was stimulated via TGF- β 1-related pathways [270].…”

Section: Traditional Use Of Medical Plants In Wound Healingmentioning

confidence: 99%

Wound Healing and the Use of Medicinal Plants

Shedoeva

Leavesley

Upton

et al. 2019

Evidence-Based Complementary and Alternative Medicine

286

164

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Cutaneous wound healing is the process by which skin repairs itself. It is generally accepted that cutaneous wound healing can be divided into 4 phases: haemostasis, inflammation, proliferation, and remodelling. In humans, keratinocytes re-form a functional epidermis (reepithelialization) as rapidly as possible, closing the wound and reestablishing tissue homeostasis. Dermal fibroblasts migrate into the wound bed and proliferate, creating “granulation tissue” rich in extracellular matrix proteins and supporting the growth of new blood vessels. Ultimately, this is remodelled over an extended period, returning the injured tissue to a state similar to that before injury. Dysregulation in any phase of the wound healing cascade delays healing and may result in various skin pathologies, including nonhealing, or chronic ulceration. Indigenous and traditional medicines make extensive use of natural products and derivatives of natural products and provide more than half of all medicines consumed today throughout the world. Recognising the important role traditional medicine continues to play, we have undertaken an extensive survey of literature reporting the use of medical plants and plant-based products for cutaneous wounds. We describe the active ingredients, bioactivities, clinical uses, formulations, methods of preparation, and clinical value of 36 medical plant species. Several species stand out, including Centella asiatica, Curcuma longa, and Paeonia suffruticosa, which are popular wound healing products used by several cultures and ethnic groups. The popularity and evidence of continued use clearly indicates that there are still lessons to be learned from traditional practices. Hidden in the myriad of natural products and derivatives from natural products are undescribed reagents, unexplored combinations, and adjunct compounds that could have a place in the contemporary therapeutic inventory.

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Section: Traditional Use Of Medical Plants In Wound Healingmentioning

confidence: 99%

Wound Healing and the Use of Medicinal Plants

Shedoeva

Leavesley

Upton

et al. 2019

Evidence-Based Complementary and Alternative Medicine

286

164

View full text Add to dashboard Cite

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“…According to authors, this nephropathy was most likely aggravated by the potential toxic effect of anthraquinone glycosides found in Rhamnus alaternus infusion extract. Anthraquinones are a group of functionally diverse chemicals structurally related to anthracene, known to be present in the roots and bark of numerous plants of the genus Rhamnus such as senna, cascara, aloe, frangula, and rhubarb used for their laxative properties [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Toxic Effects ofRhamnus alaternus: A Rare Case Report

Ghezala¹,

Chaouali²,

Gana³

et al. 2015

Case Reports in Emergency Medicine

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In Tunisia, there are about 478 species of plants commonly used in folk medicine. Medicinal plants and herbal remedies used are responsible for 2% of intoxications listed by Tunisian National Poison Center. Most cases are related to confusion between edible plants and toxic plants lookalikes or to an excessive consumption of therapeutic plants. We report the case of a 58-year-old man admitted to the Emergency Department of the Regional Hospital of Zaghouan (Tunisia), with renal failure and rhabdomyolysis. The patient reported having daily consumption of a homemade tea based on Mediterranean Buckthorn roots, during the last 6 months to treat type 2 diabetes. The aim of this work was to establish an association between the consumption of the herbal remedy and the occurrence of both renal failure and rhabdomyolysis. No similar cases have been reported in recent literature.

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“…RR contains dianthrone glycosides (sennosides A-F) and anthraquinones (chrysophanol, emodin, aloe-emodin, physcion and rhein) [ 2 ]. Several studies have investigated the pharmacological effects of RR, such as its purgative and cathartic, anti-inflammatory, anti-oxidative and anti-microbial effects [ 3 ]. Although RR has been widely used for its various pharmacological actions, it is reported that RR at high doses is toxic to the liver and kidney [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

An experimental study on providing a scientific evidence for seven-time alcohol-steaming of Rhei Rhizoma when clinically used

Sim

et al. 2015

BMC Complement Altern Med

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BackgroundRhei Rhizoma (RR) has been widely used as laxative and processed to alter its therapeutic actions or reduce its side effects. In this study, we evaluated experimentally the clinical application guideline that RR should be alcohol-steamed seven times before being used in elderly patients, as described in Dongeuibogam, the most famous book on Korean traditional medicine.MethodsUnprocessed RR (RR-U) was soaked in rice wine, steamed and then fully dried (RR-P1). The process was repeated four (RR-P4) or seven times (RR-P7). Reversed-phase high-performance liquid chromatography was used to determine the RR-U, RR-P1, RR-P4 and RR-P7 (RRs) constituents. To evaluate the effect of RRs on liver toxicity, human hepatoma cells (HepG2) were treated with RRs at 100 μg/mL for 4 h and then cell viabilities were measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. To confirm the effects in vivo, 5-week-old male Sprague–Dawley rats were treated with RRs at 3 g/kg/day for 21 days. Body weight and serum biochemical parameters were measured and liver histology was assessed.ResultsThe levels of sennosides decreased in processed RRs in an iteration-dependent manner, while the emodin level was unaffected. In HepG2 cells, cell viability was reduced with RR-U, while the toxicity decreased according to the number of processing cycles. The changes in body weight, relative liver weight and liver enzymes of RR-U-treated rats were reduced in processed RRs-treated rats. Histopathological analysis indicated swelling and cholestasis improved following seven times alcohol-steaming cycles.ConclusionsThese results provide experimental evidence that RR-P7 almost completely reduces RR hepatotoxicity.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-015-0922-y) contains supplementary material, which is available to authorized users.

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Potential Health Benefits of Rhubarb

Cited by 13 publications

References 82 publications

Wound Healing and the Use of Medicinal Plants

Wound Healing and the Use of Medicinal Plants

Toxic Effects ofRhamnus alaternus: A Rare Case Report

An experimental study on providing a scientific evidence for seven-time alcohol-steaming of Rhei Rhizoma when clinically used

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