Potential human exposures to neonicotinoid insecticides: A review

Zhang, Q.; Li, Z.; Chang, Chi-Hsuan; Lou, Jianlin; Zhao, Meirong; Lu, Chensheng

doi:10.1016/j.envpol.2017.12.101

Cited by 185 publications

(77 citation statements)

References 57 publications

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“…The concentrations of thiacloprid required to block OAT3 and OCT2 activities are, however, in the 20 to 60 µM (5‐15 µg/mL) range, whereas the tested concentration of other neonicotinoids was 100 µM. Such concentrations are much higher than environmental concentrations of neonicotinoid pesticides . Indeed, maximal levels of neonicotinoid pesticides in water samples in agricultural areas in North America are up to 0.012 µM, whereas concentrations of metabolites of thiacloprid and imidacloprid in the urine of farm workers are up to 0.05 µM and average total neonicotinoid level in animal milk is 16.1 pg/mL .…”

Section: Discussionmentioning

confidence: 91%

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Neonicotinoid pesticides poorly interact with human drug transporters

Vée

Bacle

Bruyère

et al. 2019

J Biochem & Molecular Tox

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The interactions of six neonicotinoid pesticides and one neonicotinoid metabolite with drug transporters have been characterized in vitro. Acetamiprid, clothianidin, imidacloprid, nitenpyram, thiacloprid and its metabolite thiacloprid amide, and thiamethoxam, each used at 100 µM, did not impair activity of the efflux pumps P‐glycoprotein, multidrug resistance‐associated proteins, and breast cancer resistance protein. They also did not inhibit that of the uptake transporters OATP1B1, OATP1B3, OAT4, and MATE1, whereas that of OATP2B1, OAT1, and MATE2‐K was affected by only one of the seven neonicotinoids. Activity of OCT1 was moderately stimulated (up to 1.5‐fold) by several neonicotinoids. By contrast, that of OAT3 and OCT2 was inhibited by most (OAT3), if not all (OCT2), neonicotinoids, with IC50 values in the 20 to 60 µM range for thiacloprid, likely not relevant to environmental exposure. Thiacloprid was moreover not transported by OAT3 and OCT2. Overall, these data suggest that neonicotinoid pesticides rather poorly interact with drug transporter activities.

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Section: Discussionmentioning

confidence: 91%

“…Widespread exposure of humans to neonicotinoids has been suggested, notably through ingestion of contaminated foods or inhalation . However, because all neonicotinoids are highly specific for insect nAChRs, they are thought to exert low toxicity on humans .…”

Section: Introductionmentioning

confidence: 99%

Neonicotinoid pesticides poorly interact with human drug transporters

Vée

Bacle

Bruyère

et al. 2019

J Biochem & Molecular Tox

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“…The increasing global usage of pesticides has allowed many chemicals of concern to persist in the environment. Pesticide exposures have been linked to several negative human health effects, such as asthma; cancer; and disruption of the nervous, endocrine, and reproductive systems [40][41][42][43][44][45][46]. Young children and pregnant women are particularly sensitive to pesticide exposures [5,7,[47][48][49][50][51], which have been linked to delays in human fetal development and lifelong neurotoxic disabilities [52][53][54][55][56].…”

Section: Discussionmentioning

confidence: 99%

Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11

Shields

Hales

Ranspach

et al. 2019

Toxics

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Recent studies suggest that organophosphates and carbamates affect human fetal development, resulting in neurological and growth impairment. However, these studies are conflicting and the extent of adverse effects due to pesticide exposure warrants further investigation. In the present study, we examined the impact of the carbamate insecticide propoxur on zebrafish development. We found that propoxur exposure delays embryonic development, resulting in three distinct developmental stages: no delay, mild delay, or severe delay. Interestingly, the delayed embryos all physically recovered 5 days after exposure, but behavioral analysis revealed persistent cognitive deficits at later stages. Microarray analysis identified 59 genes significantly changed by propoxur treatment, and Ingenuity Pathway Analysis revealed that these genes are involved in cancer, organismal abnormalities, neurological disease, and hematological system development. We further examined hspb9 and hspb11 due to their potential roles in zebrafish development and found that propoxur increases expression of these small heat shock proteins in all of the exposed animals. However, we discovered that less significant increases were associated with the more severely delayed phenotype. This raises the possibility that a decreased ability to upregulate these small heat shock proteins in response to propoxur exposure may cause embryos to be more severely delayed.

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“…Despite the widespread use of neonicotinoids, information about human exposures and the potential human health effects is relatively lacking . It is considered that most neonicotinoids (imidacloprid, clothianidin, thiamethoxam, and acetamiprid) are not harmful for humans and according to the Annual Cancer Report 2016 of US EPA they do not present genotoxic or carcinogenic effects .…”

Section: Characteristics Of the Pesticides From The Eu First And Secomentioning

confidence: 99%

Pesticides from the EU First and Second Watch Lists in the Water Environment

Pietrzak

Kania

Malina

et al. 2019

CLEAN Soil Air Water

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The contamination of water with pesticides used in agriculture and urban areas is a priority issue that is currently of global concern. In 2015, the European Union (EU) published the first Watch List (1st WL), which showed the necessity for Union‐wide monitoring of ten organic substances/groups of substances in the field of water policy. The list includes, among other items, eight pesticides: five neonicotinoids (acetamiprid, clothianidin, imidacloprid, thiacloprid, and thiamethoxam), and methiocarb, oxadiazon, and tri‐allate. In 2018 the EU published the second Watch List, which repealed the 1st WL. In this list, among other changes, one pesticide (metaflumizone) was added, and two (oxadiazon and tri‐allate) were removed. This review summarizes the current state of knowledge on the reported occurrence and concentrations of these pesticides in surface and groundwaters and in effluents from wastewater treatment plants derived from 73 studies in 21 countries worldwide. Imidacloprid, acetamiprid and thiamethoxam were the most frequently found pesticides due to their widespread use, while metaflumizone, methiocarb, oxadiazon, and tri‐allate are less studied pesticides whose occurrence in water is also poorly reported. More investigation is needed to assess the occurrence and impact of these pesticides on the aquatic environment worldwide in the context of water supply and human security.

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Potential human exposures to neonicotinoid insecticides: A review

Cited by 185 publications

References 57 publications

Neonicotinoid pesticides poorly interact with human drug transporters

Neonicotinoid pesticides poorly interact with human drug transporters

Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11

Pesticides from the EU First and Second Watch Lists in the Water Environment

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