Potential Hypoglycemic Agents: 1,3,4-Oxadiazoles and Related Compounds

Abstract

Purine-6-alkylsulfonamides Listed in Table II.-The appropriate amine (0.0747 mole) (see Table II) in 50 ml. of water was cooled to 15°and stirred as 5 g. (0.0247 mole) of 6-sulfonylfluoropurine6 was added in small portions so that the temperature of the mixture did not exceed 20°. This mixture was stirred for 15 min. and then acidified with glacial acetic acid. The precipitate that formed was filtered, washed with water, dried at 60°, and then recrvstallized from the indicated solvent (Table II).

Synthesis and Biological Activity of 1‐(Substituted phenoxyacetoxy)‐1‐(pyridin‐2‐yl or thien‐2‐yl)methylphosphonates

“…On the other hand, a-substituted alkylphosphonate derivatives have received considerable attention in medicine and pesticide chemistry because of their biological activities over the past two decades [13][14][15][16][17]. Especially, in our previous work, a series of 1-(substituted phenoxyacetoxy) alkylphosphonates, as potent pyruvate dehydrogenase complex inhibitors, were synthesized and showed notable herbicidal activities [18][19][20][21][22][23].…”

Thermo-physical properties of 1,3,4-oxadiazole derivatives in pure solvents

“…The compounds 1,3,4-oxadiazole heterocycles are good bioisosteres of amides and esters, which can contribute substantially in increasing pharmacological activity by participating in hydrogen bonding interactions with the receptors [3]. The 2,5-disubstituted-1,3,4-oxadiazole derivatives are known for various pharmacological activities such as antibacterial [4], anti-inflammatory [5], analgesic [6], antiviral and anticancer [7], antihypertensive [8], anticonvulsant [9], antiproliferative [10], herbicidal [11], hypoglycemic [12], hypnotic and sedative [13], MAO inhibitor [14] and insecticidal [15].…”

Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity

“…The substituted oxadiazoles serve both as biomimetic and reactive pharmacophores. Such compounds offer a privileged motif in medicinal chemistry; such as antidiabetic [22], anticancer [23], antialzimer activity, inhibitors of glycogen synthase kinase-3β [24], insecticidal [25], bactericidal [26], hypoglycemic [27], analgesic, anticonvulsive, antiemetic, diuretic [28], muscle relaxant [29,30], herbicidal [31,32] and fungicidal activity [33,34].…”