Potential impact of a presumed increase in the biting activity of dengue-virus-infected Aedes aegypti (Diptera: Culicidae) females on virus transmission dynamics

Luz, Paula M.; Lima-Camara, Tamara Nunes; Bruno, Rafaela Vieira; Castro, Márcia Gonçalves de; Sorgine, Marcos Henrique Ferreira; Lourenço‐de‐Oliveira, Ricardo; Peixoto, Alexandre A.

doi:10.1590/s0074-02762011000600017

Cited by 31 publications

(22 citation statements)

References 29 publications

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“…Alternatively, the most cost-effective strategy consisted of six high efficacy adulticide applications per year, reducing the disease burden to the greatest extent and meeting WHO's standard for a cost-effective intervention. Luz et al used a simplified formulation of their model [40] to investigate the potential impact of increased biting rates in dengue infected mosquitoes [42]. The effect of dengue infection on mosquito feeding behavior is not clearly established and different studies yielded controversial results [43], [44].…”

Section: Resultsmentioning

confidence: 99%

“…However, two recent experimental studies support the differential biting rate assumption [45], [46]. Using numerical simulations, Luz et al showed that an increase of 50% of the biting frequency would produce an increase of the numbers of primary and secondary dengue infections of 3.8% and 6.5%, respectively [42]. Another potential vector control strategy, based on the Release of Insects carrying a Dominant Lethal (RIDL) was studied by Atkinson et al [47].…”

Section: Resultsmentioning

confidence: 99%

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Dynamic Epidemiological Models for Dengue Transmission: A Systematic Review of Structural Approaches

et al. 2012

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Dengue is a vector-borne disease recognized as the major arbovirose with four immunologically distant dengue serotypes coexisting in many endemic areas. Several mathematical models have been developed to understand the transmission dynamics of dengue, including the role of cross-reactive antibodies for the four different dengue serotypes. We aimed to review deterministic models of dengue transmission, in order to summarize the evolution of insights for, and provided by, such models, and to identify important characteristics for future model development. We identified relevant publications using PubMed and ISI Web of Knowledge, focusing on mathematical deterministic models of dengue transmission. Model assumptions were systematically extracted from each reviewed model structure, and were linked with their underlying epidemiological concepts. After defining common terms in vector-borne disease modelling, we generally categorised fourty-two published models of interest into single serotype and multiserotype models. The multi-serotype models assumed either vector-host or direct host-to-host transmission (ignoring the vector component). For each approach, we discussed the underlying structural and parameter assumptions, threshold behaviour and the projected impact of interventions. In view of the expected availability of dengue vaccines, modelling approaches will increasingly focus on the effectiveness and cost-effectiveness of vaccination options. For this purpose, the level of representation of the vector and host populations seems pivotal. Since vector-host transmission models would be required for projections of combined vaccination and vector control interventions, we advocate their use as most relevant to advice health policy in the future. The limited understanding of the factors which influence dengue transmission as well as limited data availability remain important concerns when applying dengue models to real-world decision problems.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Dynamic Epidemiological Models for Dengue Transmission: A Systematic Review of Structural Approaches

et al. 2012

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“…In a simplified mathematical model, if we assume an increase in the biting rate of infected Ae. aegypti , the number of primary and secondary infections also increases ( Luz et al 2011 ). However, the molecular mechanism behind this control has never been explored.…”

Section: Discussionmentioning

confidence: 99%

Circadian clock of Aedes aegypti: effects of blood-feeding, insemination and RNA interference

Gentile

Rivas

Lima

et al. 2013

Mem. Inst. Oswaldo Cruz

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Mosquitoes are the culprits of some of the most important vector borne diseases. A species’ potential as a vector is directly dependent on their pattern of behaviour, which is known to change according to the female’s physiological status such as whether the female is virgin/mated and unfed/blood-fed. However, the molecular mechanism triggered by and/or responsible for such modulations in behaviour is poorly understood. Clock genes are known to be responsible for the control of circadian behaviour in several species. Here we investigate the impact mating and blood-feeding have upon the expression of these genes in the mosquito Aedes aegypti . We show that blood intake, but not insemination, is responsible for the down-regulation of clock genes. Using RNA interference, we observe a slight reduction in the evening activity peak in the fourth day after dstim injection. These data suggest that, as in Drosophila , clock gene expression, circadian behaviour and environmental light regimens are interconnected in Ae. aegypti .

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“…Typical formulations of the equation assume that the biting rate of mosquitoes is unchanged, regardless of infection status. However, the reduction in specific proteins identified in this research, combined with the changes in feeding behavior of DENV-infected mosquitoes seen by others, would indicate that this assumption may be violated in nature and would have consequences for transmission [63,64,67]. Thus, a separate parameter of a INF to account for this alteration in vector biting rate due to infection status is appropriate.…”

Section: Discussionmentioning

confidence: 86%

Infection with dengue-2 virus alters proteins in naturally expectorated saliva of Aedes aegypti mosquitoes

et al. 2014

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BackgroundDengue virus (DENV) is responsible for up to approximately 300 million infections and an increasing number of deaths related to severe manifestations each year in affected countries throughout the tropics. It is critical to understand the drivers of this emergence, including the role of vector-virus interactions. When a DENV-infected Aedes aegypti mosquito bites a vertebrate, the virus is deposited along with a complex mixture of salivary proteins. However, the influence of a DENV infection upon the expectorated salivary proteome of its vector has yet to be determined.MethodsTherefore, we conducted a proteomic analysis using 2-D gel electrophoresis coupled with mass spectrometry based protein identification comparing the naturally expectorated saliva of Aedes aegypti infected with DENV-2 relative to that of uninfected Aedes aegypti.ResultsSeveral proteins were found to be differentially expressed in the saliva of DENV-2 infected mosquitoes, in particular proteins with anti-hemostatic and pain inhibitory functions were significantly reduced. Hypothetical consequences of these particular protein reductions include increased biting rates and transmission success, and lead to alteration of transmission potential as calculated in our vectorial capacity model.ConclusionsWe present our characterizations of these changes with regards to viral transmission and mosquito blood-feeding success. Further, we conclude that our proteomic analysis of Aedes aegypti saliva altered by DENV infection provides a unique opportunity to identify pro-viral impacts key to virus transmission.

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Potential impact of a presumed increase in the biting activity of dengue-virus-infected Aedes aegypti (Diptera: Culicidae) females on virus transmission dynamics

Abstract: Recently, we showed that infection with dengue virus increases the locomotor activity of

Cited by 31 publications

References 29 publications

Dynamic Epidemiological Models for Dengue Transmission: A Systematic Review of Structural Approaches

Dynamic Epidemiological Models for Dengue Transmission: A Systematic Review of Structural Approaches

Circadian clock of Aedes aegypti: effects of blood-feeding, insemination and RNA interference

Infection with dengue-2 virus alters proteins in naturally expectorated saliva of Aedes aegypti mosquitoes

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