Potential impact on blood availability and donor iron status of changes to donor hemoglobin cutoff and interdonation intervals

Spencer, Bryan R.; Johnson, Bryce; Wright, David J.; Kleinman, Steven; Glynn, Simone A.; Cable, Ritchard G.

doi:10.1111/trf.13663

Cited by 34 publications

(51 citation statements)

References 10 publications

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“…During three consecutive months, FTDs who were eligible for blood donation according to the National Hemotherapy Guidelines were approached to participate in the study. FTDs were defined as donors having their first blood donation in life . Donors who donated blood for the first time at the Greifswald blood donation centre, but who had already donated blood before at another blood service, were excluded.…”

Section: Methodsmentioning

confidence: 99%

Well‐being and return rate of first‐time whole blood donors

et al. 2019

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Background and objectives Previous studies observed a transient increase in well‐being in about one‐third of regular donors after blood donation. In addition, personal contact with donors after donation seems to increase return rates. We were interested whether changes in well‐being and/or personal contact after the first donation impact return rates of first‐time donors (FTDs). Materials and methods First‐time donors were randomized to a questionnaire group (QG), in which questionnaires assessing the well‐being had to be filled in, or a control group (CG), which was not contacted with a questionnaire. The QG had to complete the same questionnaire three times at the day of the first donation and then four times over an 8‐week period with reminding calls by the study coordinator. Return rates of participants were followed for 12 months. Results A total of 102 FTDs participated in the QG and 115 in the CG. Changes in well‐being after the first donation had minimal impact on the return rates. In contrast, contacting FTDs after their first donation had a significant impact on the return rate of male donors (89·2% in the QG vs. 58·3% in the CG; P = 0·001). Females showed no significant difference in return rates between both groups (P = 0·32). Conclusion The well‐being of FTDs had no influence on their return rate. The intervention of regular contacts during a research project follow‐up resulted in an increased return rate of male but not of female FTDs. The pronounced difference of the impact of this intervention between male and female donors requires further studies.

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Section: Methodsmentioning

confidence: 99%

Well‐being and return rate of first‐time whole blood donors

et al. 2019

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“…Iron depletion is common in blood donors, estimated to be present in 33% of US donors . The prevalence of iron depletion is directly related to donation intensity and, therefore, is present in approximately two‐thirds of female and half of male donors who donate frequently .…”

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confidence: 99%

Elevated risk for iron depletion in high‐school age blood donors

et al. 2019

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BACKGROUND High school students 16 to 18 years‐old contribute 10% of the US blood supply. Mitigating iron depletion in these donors is important because they continue to undergo physical and neurocognitive development. STUDY DESIGN AND METHODS Study objectives were to determine the prevalence of iron depletion in 16‐ to 18‐year‐old donors and whether their risk for iron depletion was greater than adult donors. Successful, age‐eligible donors were enrolled from high school blood drives at two large US blood centers. Plasma ferritin testing was performed with ferritin less than 12 ng/mL as our primary measure of iron depletion and ferritin less than 26 ng/mL a secondary measure. Multivariable repeated‐measures logistic regression models evaluated the role of age and other demographic/donation factors. RESULTS Ferritin was measured from 4265 enrollment donations September to November 2015 and 1954 follow‐up donations through May 2016. At enrollment, prevalence of ferritin less than 12 ng/mL in teenagers was 1% in males and 18% in females making their first blood donation, and 8% in males and 33% in females with prior donations. Adjusted odds for ferritin less than 12 ng/mL were 2.1 to 2.8 times greater in 16‐ to 18‐year‐olds than in 19‐ to 49‐year‐olds, and for ferritin less than 26 ng/mL were 3.3‐ to 4.7‐fold higher in 16‐ to 18‐year‐olds. Progression to hemoglobin deferral was twice as likely in 16‐ to 18‐year‐old versus 19‐ to 49‐year‐old females. CONCLUSION Age 16 to 18 years‐old is an independent risk factor for iron deficiency in blood donors at any donation frequency. Blood centers should implement alternate eligibility criteria or additional safety measures to protect teenage donors from iron depletion.

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“…It is difficult to predict both positive and negative outcomes of donor policy changes . Spencer et al performed a modeling study using data from six US blood centers participating in the Retrovirus Epidemiology Donor Study‐II (REDS II) to estimate the impact of various changes in donor Hb cutoffs and interdonation intervals on blood availability and donor iron status . A similar exercise was performed by Gandhi et al using a much smaller dataset from the Mayo Clinic Rochester donor center .…”

Section: Discussionmentioning

confidence: 99%

Changes in minimum hemoglobin and interdonation interval: impact on donor hemoglobin and donation frequency

Goldman

Steed

et al. 2019

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BACKGROUND To reduce donor iron deficiency in whole blood donors, we changed our hemoglobin (Hb) cutoff in males and interdonation interval in females. STUDY DESIGN AND METHODS A change in messaging to females in fall 2016 was followed by changing the interdonation interval from 56 to 84 days in the appointment booking system (December 2016) and actual donation criterion (March 2017). The minimum Hb for males increased from 125 g/L to 130 g/L (March 2017). We evaluated Hb levels and deferral rates, donor presentations with a Hb level below 120 g/L, donation frequency, and donor base size before and after these changes. RESULTS The Hb deferral rate decreased in females from 13.0% to 9.5%, increased in males from 1.2% to 2.1%, and decreased overall from 6.8% to 5.4% (all p < 0.001). Mean Hb increased from 135.0 g/L to 136.2 g/L in females and from 149.9 g/L to 150.6 g/L in males (both p < 0.0001). The percentage of presentations with Hb below 120 g/L decreased by 27% in males and females (p < 0.001). Annual donation frequency decreased by 12% in females and 4% in males; the donor base was expanded by 5.8%. CONCLUSIONS Many positive impacts were seen for female donors, including a shift in the Hb distribution curve to the right, and a large reduction in Hb deferrals. For males, there was an increase in Hb deferrals and a small increase in mean Hb. Changes were related to both reduced donation frequency and a shift in composition of the donor base.

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Potential impact on blood availability and donor iron status of changes to donor hemoglobin cutoff and interdonation intervals

Cited by 34 publications

References 10 publications

Well‐being and return rate of first‐time whole blood donors

Well‐being and return rate of first‐time whole blood donors

Elevated risk for iron depletion in high‐school age blood donors

Changes in minimum hemoglobin and interdonation interval: impact on donor hemoglobin and donation frequency

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