Understanding the social vulnerabilities and community strategies to adapt to environmental changes are crucial for the development of actions to enhance both community conservation and survival. With the aim to identify the drivers of vulnerability to climate change among different coastal communities a comprehensive multiscale vulnerability framework was here adopted. Eight selected fishing communities representative of the South Brazil Bight (SBB) area were surveyed at the household level. A total of 151 fishers were interviewed. Quantitative indicators were calculated at the community-level, and their drivers identified, allowing for comparisons of the overall vulnerability score. Findings revealed that remoteness and the lack of climate changerelated institutional support increase vulnerability among fishing communities in the region. On the other hand, community organization, leadership, research partnerships, community-based co-management, and livelihood diversification reduce vulnerability. Our analysis focused on social vulnerability to climate change in regional fishing communities and provides a better understanding of these effects in coastal zones, the factors explaining vulnerability and some perspectives on resilient and adaptable systems. Learning from comparisons at the ecosystem level may be applied to coastal regions elsewhere.