Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota

Wu, Min; Luo, Qingying; Nie, Rongxuan; Yang, Xingpan; Tang, Zizhong; Hong, Chen

doi:10.1080/10408398.2020.1773390

Cited by 128 publications

(91 citation statements)

References 120 publications

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“…Consistently, analyses in the PREDIMED cohort found no association between the antioxidant capacity of the diet and mortality [ 59 ], while observing a reduced risk of CVD associated with dietary polyphenols [ 37 ]. Similarly, in a cohort of postmenopausal women, dietary polyphenol intake—but not the dietary total antioxidant capacity—was inversely related to cardiovascular disease risk [ 60 ], suggesting that mechanisms other than antioxidant activity may be responsible for the health benefits of polyphenols, including positive modulation of gut microbiota [ 61 ] and reduction of inflammation [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, such potential limitations were mitigated by energy adjustment. Also, the validated FFQ used in this study has been previously largely employed and has been reported to have predictive validity for a number of health outcomes [ 61 , 62 ]. Third, our data were obtained from a cohort of adults residing in a small Southern Italian region, and this might limit the generalizability of our findings, although the main characteristics of our population are comparable to those of the Italian Cardiovascular Epidemiological Observatory and are therefore representative of at least the Italian population [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

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Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study

et al. 2021

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Biological aging, or the discrepancy between biological and chronological age of a subject (Δage), has been associated with a polyphenol-rich Mediterranean diet and represents a new, robust indicator of cardiovascular disease risk. We aimed to disentangle the relationship of dietary polyphenols and total antioxidant capacity with Δage in a cohort of Italians. A cross-sectional analysis was performed on a sub-cohort of 4592 subjects (aged ≥ 35 y; 51.8% women) from the Moli-sani Study (2005–2010). Food intake was recorded by a 188-item food-frequency questionnaire. The polyphenol antioxidant content (PAC)-score was constructed to assess the total dietary content of polyphenols. Total antioxidant capacity was measured in foods by these assays: trolox equivalent antioxidant capacity (TEAC), total radical-trapping antioxidant parameter (TRAP) and ferric reducing-antioxidant power (FRAP). A deep neural network, based on 36 circulating biomarkers, was used to compute biological age and the resulting Δage, which was tested as outcome in multivariable-adjusted linear regressions. Δage was inversely associated with the PAC-score (β = −0.31; 95%CI −0.39, −0.24) but not with total antioxidant capacity of the diet. A diet rich in polyphenols, by positively contributing to deceleration of the biological aging process, may exert beneficial effects on the long-term risk of cardiovascular disease and possibly of bone health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study

et al. 2021

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“…Natural compounds such as polyphenols display interesting medicinal properties. These polyphenols may reduce certain age-associated diseases such as cancer and Alzheimer’s disease by mitigating increased cellular damage through the reduction of reactive oxygen species (ROS) by the down-regulation of antioxidant enzymes [ 2 , 3 ] and the modulation of the inflammatory status, autophagy function and gut microbiota [ 4 ]. The antiproliferative and cytotoxic effects of polyphenols on cancer cells are attributed to cell cycle arrest and the molecular regulation of specific genes [ 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Biological Activities of Acacia saligna and Lawsonia inermis Natural Populations

Elansary

Szopa

Kubica

et al. 2020

Plants

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Acacia saligna and Lawsonia inermis natural populations growing in Northern Saudi Arabia might be a valuable source of polyphenols with potent biological activities. Using high-performance liquid chromatography–diode array detection (HPLC-DAD), several polyphenols were detected tentatively in considerable amounts in the methanolic leaf extracts of A. saligna and L. inermis. A. saligna mainly contained rutoside, hyperoside, quercetin 3-glucuronide, gallic acid and p-coumaric acid, whereas those of L. inermis contained apigenin 5-glucoside, apigetrin and gallic acid. Strong antioxidant activities were found in the leaf extracts of both species due to the presence of hyperoside, quercetin 3-glucuronide, gallic acid, isoquercetin, p-coumaric acid, quercitrin and rutoside. A. saligna and L. inermis leaf extracts as well as hyperoside, apigenin 5-glucoside, and quercetin 3-glucuronide significantly reduced reactive oxygen species accumulation in all investigated cancer cells compared to the control. Methanolic leaf extracts and identified polyphenols showed antiproliferative and cytotoxic activities against cancer cells, which may be attributed to necrotic cell accumulation during apoptotic periods. Antibacterial activities were also found in both species leaf extracts and were twice as high in A. saligna than L. inermis due to the high composition of rutoside and other polyphenols. Finally, strong antifungal activities were detected, which were associated with specific phenols such as rutoside, hyperoside, apigenin 5-glucoside and p-coumaric acid. This is the first study exploring the polyphenolic composition of A. saligna and L. inermis natural populations in northern Saudi Arabia and aiming at the detection of their biological activities.

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“…Natural populations of medicinal plants have been a valuable source of therapeutic compounds and drug discovery [ 1 ]. These compounds include polyphenols which may reduce certain age-associated illnesses including cancer and Alzheimer’s disease by confronting escalated cellular damage through significant reduction of reactive oxygen species (ROS) and inflammatory status [ 2 , 3 ]. The antiproliferative and cytotoxic activities of polyphenols against human cancer cells are also attributed to cell cycle arrest and intermolecular regulation of known genes [ 4 , 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Polyphenols of Frangula alnus and Peganum harmala Leaves and Associated Biological Activities

Elansary

Szopa

Kubica

et al. 2020

Plants

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Frangula alnus and Peganum harmala populations growing in Saudi Arabia might be rich sources of natural compounds with important biological activities. A high performance liquid chromatography diode array revealed several polyphenols in the leaf extracts for the first time, including p-coumaric acid, rosmarinic acid, chlorogenic acid, ferulic acid, quercitrin, rutoside, quercetin and trifolin in F. alnus; and hydrocaffeic acid, protocatechuic acid, rosmarinic acid, caffeic acid and cynaroside in P. harmala. F. alnus and P. harmala showed strong antioxidant effects attributed to the polyphenolic composition of leaves and reduction of reactive oxygen species (ROS) accumulation. F. alnus and P. harmala leaf extracts showed cytotoxic effects against Jurkat, MCF-7, HeLa, and HT-29 cancer cells using MTT and flow cytometry assays. These activities were attributed to the polyphenolic composition of leaves including quercitrin, trifolin and cymaroside, as well as the activation of caspase family enzymes 2, 6, 8 and 9 in treated cancer cells compared to control. The current findings of this study include a novel comprehensive investigation on the polyphenol composition and anticancer effects of leaf extracts of F. alnus and P. harmala from natural populations in Saudi Arabia.

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Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota

Cited by 128 publications

References 120 publications

Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study

Dietary Polyphenol Intake Is Associated with Biological Aging, a Novel Predictor of Cardiovascular Disease: Cross-Sectional Findings from the Moli-Sani Study

Antioxidant and Biological Activities of Acacia saligna and Lawsonia inermis Natural Populations

Polyphenols of Frangula alnus and Peganum harmala Leaves and Associated Biological Activities

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