Potential Implications of Quercetin in Autoimmune Diseases

Shen, Pan; Lin, Wei Chen; Deng, Xuan; Ba, Xin; Liang, Han; Chen, Zhe; Qin, Kai; Huang, Ying; Tu, Shenghao

doi:10.3389/fimmu.2021.689044

Cited by 139 publications

(89 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other authors suggest that even in 10 mg/kg quercetin can protect the heart from EAM-induced damage via modulation of MAPK signaling cascade, more precisely by suppressing the myocardial endothelin-1 and also the mitogen-activated protein kinases (MAPK) [ 36 ]. Potent anti-inflammatory properties of quercetin have also been confirmed in other autoimmune diseases [ 37 , 38 ]. Another flavonoid component of MOEs, catechin ,was also shown to exert protective effects in the EAM rat model by decreasing cardiac remodeling, inflammatory infiltrate, and fibrosis possibly via decreased expression of NF- κ B and ICAM-1 [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Melissa officinalis L. Supplementation Provides Cardioprotection in a Rat Model of Experimental Autoimmune Myocarditis

Draginić

Jakovljević

Jeremić

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Due to existing evidence regarding antioxidant and anti-inflammatory effects of Melissa officinalis extracts (MOEs), this study was aimed at investigating the potential of ethanolic MOE to prevent the development of myocarditis and its ability to ameliorate the severity of experimental autoimmune myocarditis (EAM) by investigating MOE effects on in vivo cardiac function, structure, morphology, and oxidative stress parameters. A total of 50 7-week-old male Dark Agouti rats were enrolled in the study and randomly allocated into the following groups: CTRL, nontreated healthy rats; EAM, nontreated rats with EAM; MOE50, MOE100, and MOE200, rats with EAM treated with either 50, 100, or 200 mg/kg of MOE for 3 weeks per os. Myocarditis was induced by immunization of the rats with porcine myocardial myosin (0.5 mg) emulsion on day 0. Cardiac function and dimensions of the left ventricle (LV) were assessed via echocardiography. Additionally, the blood pressure and heart rate were measured. On day 21, rats were sacrificed and the hearts were isolated for further histopathological analyses (H/E and Picrosirius red staining). The blood samples were collected to determine oxidative stress parameters. The EAM group characteristically showed greater LV wall thickness and lower ejection fraction ( 50.33 ± 7.94 % vs. 84.81 ± 7.74 %) and fractional shortening compared to CTRL ( p < 0.05 ). MOE significantly improved echocardiographic parameters (EF in MOE200 81.44 ± 5.51 %) and also reduced inflammatory infiltrate (by 88.46%; p < 0.001 ) and collagen content (by 76.39%; p < 0.001 ) in the heart tissues, especially in the MOE200 group compared to the EAM group. In addition, MOEs induced a significant decrease of prooxidants production (O2-, H2O2, and TBARS) and improved antioxidant defense system via increase in GSH, SOD, and CAT compared to EAM, with medium and high dose being more effective than low dose ( p < 0.05 ). The present study suggests that ethanolic MOEs, especially in a 200 mg/kg dose, improve cardiac function and myocardial architecture, possibly via oxidative stress mitigation, thus preventing heart remodeling, development of dilated cardiomyopathy, and subsequent heart failure connected with EAM. MOEs might be considered as a potentially helpful adjuvant therapy in patients with autoimmune myocarditis.

show abstract

Section: Discussionmentioning

confidence: 99%

Melissa officinalis L. Supplementation Provides Cardioprotection in a Rat Model of Experimental Autoimmune Myocarditis

Draginić

Jakovljević

Jeremić

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

show abstract

“…With citrulline's role as a gut biomarker, and a functional metabolite of the gut, as well as the numerous reports supporting quercetin's role in gut microbiota modulation, we suggest that synergistic effects may exist when these two substances are co-utilized, considering they have similar attributes of antioxidative, anti-inflammatory, and immuneregulatory roles in the gut, especially under pathophysiological conditions. Importantly, the effectiveness of quercetin in alleviating colitis and IBD treatment is impeded due to its rapid metabolism and primary absorption in the upper gastrointestinal tract, as such limiting its transit and absorption in the lower gastrointestinal tract [199]. This problem is counteracted by supplying quercetin in its glycosylated form, commonly as rutin, which allows for passage through the epithelial cells, and conversion by the gut microbiota to derive the bioactive effects of quercetin [199].…”

Section: Knowledge Gaps and Future Perspectivesmentioning

confidence: 99%

“…Importantly, the effectiveness of quercetin in alleviating colitis and IBD treatment is impeded due to its rapid metabolism and primary absorption in the upper gastrointestinal tract, as such limiting its transit and absorption in the lower gastrointestinal tract [199]. This problem is counteracted by supplying quercetin in its glycosylated form, commonly as rutin, which allows for passage through the epithelial cells, and conversion by the gut microbiota to derive the bioactive effects of quercetin [199]. Moreover, in the gut, citrulline is easily absorbed by the gut from the enterocytes lumen such that oral supplementation with citrulline is more efficient than with arginine supplementation to supply arginine [37].…”

Section: Knowledge Gaps and Future Perspectivesmentioning

confidence: 99%

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

et al. 2021

View full text Add to dashboard Cite

The importance of gut health in animal welfare and wellbeing is undisputable. The intestinal microbiota plays an essential role in the metabolic, nutritional, physiological, and immunological processes of animals. Therefore, the rapid development of dietary supplements to improve gut functions and homeostasis is imminent. Recent studies have uncovered the beneficial effects of dietary supplements on the immune response, microbiota, gut homeostasis, and intestinal health. The application of citrulline (a functional gut biomarker) and quercetin (a known potent flavonoid) to promote gut functions has gained considerable interest as both bioactive substances possess anti-inflammatory, anti-oxidative, and immunomodulatory properties. Research has demonstrated that both citrulline and quercetin can mediate gut activities by combating disruptions to the intestinal integrity and alterations to the gut microbiota. In addition, citrulline and quercetin play crucial roles in maintaining intestinal immune tolerance and gut health. However, the synergistic benefits which these dietary supplements (citrulline and quercetin) may afford to simultaneously promote gut functions remain to be explored. Therefore, this review summarizes the modulatory effects of citrulline and quercetin on the intestinal integrity and gut microbiota, and further expounds on their potential synergistic roles to attenuate intestinal inflammation and promote gut health.

show abstract

“… 35 Recently, the potential effects of important natural plant-based compounds and their derivatives such as resveratrol, curcumin, matrine, quercetin, and sylimarin, have been extensively investigated on a variety of disorders including autoimmunity. 16 , 36 – 43 The majority of natural/herbal medications can control different diseases by inhibiting pro-inflammatory mediators and increasing the frequency and activity of Tregs. 36 , 44 – 46 Therefore, medicinal plants are important sources for development of new immunomodulatory and anti-inflammatory drugs.…”

Section: Discussionmentioning

confidence: 99%

Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approach

Yousefi

Mirsanei

Bitaraf

et al. 2022

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Introduction: Rheumatoid arthritis (RA) is an autoimmune disease that is identified with chronic inflammation and progressive destruction of the joints. The defective activity of regulatory T cells (Tregs) plays a crucial role in RA development. Oleuropein (OLEU) is the most common polyphenolic compound in olive leaf extracts with numerous pharmacological activities. In this study, the potential effects of OLEU in shifting CD4+ T cells toward Tregs are evaluated in patients with RA. Methods 32 healthy controls (HC) and 45 RA patients were included in two groups. The immunoturbidometric technique was used to measure serum levels of c-reactive protein (CRP) and rheumatoid factor (RF). Isolated CD4+ T cells from peripheral blood mononuclear cells (PBMCs) of HC and RA patients were cultured with appropriate concentrations of OLEU. The cytotoxicity effects of OLEU were determined using the MTT assay at 24, 48, and 72 h. The percentage of CD4+CD25 + FoxP3 regulatory T lymphocytes (Tregs) and the expressions of IL-10 and TGF-β were evaluated by flow cytometry and immunoassay techniques after treatment of cells with different concentrations of OLEU for 24 h. The serum levels of RF and CRP in patients with RA were 11.8 ± 5.32 IU/ml and 6.36 ± 5.82 mg/l, respectively. Results OLEU had a dose-dependent effect on the CD4+ T cells via increasing the frequency of CD4+CD25 + FoxP3 Tregs ( p = 0.0001). Moreover, it induced the production of IL-10 ( p = 0.0001) and TGF-β ( p < 0.01) in both HC and RA patients. Conclusion The findings of this study suggest that OLEU may have immunomodulatory effects by inducing Tregs, and it might help in developing a novel nutrition strategy for management of autoimmune diseases such as RA.

show abstract

Potential Implications of Quercetin in Autoimmune Diseases

Cited by 139 publications

References 82 publications

Melissa officinalis L. Supplementation Provides Cardioprotection in a Rat Model of Experimental Autoimmune Myocarditis

Melissa officinalis L. Supplementation Provides Cardioprotection in a Rat Model of Experimental Autoimmune Myocarditis

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

Dose-dependent effects of oleuropein administration on regulatory T-cells in patients with rheumatoid arthritis: An in vitro approach

Contact Info

Product

Resources

About