1997
DOI: 10.1002/(sici)1520-6823(1997)5:4<180::aid-roi3>3.3.co;2-z
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Potential indicators of radiosensitivity in squamous cell carcinoma of the head and neck

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Cited by 26 publications
(30 citation statements)
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“…EGFR amplification and/or overexpression are frequently diagnosed in high-grade gliomas but in some studies no association between amplification of EGFR and patient survival was seen [5,10], while other studies showed prognostic relevance of EGFR amplification for patient outcome [20,37]. In squamous cell carcinoma of the head and neck high levels of expression of EGFR are correlated with low radiosensitivity [16,32]. In our series the results are too preliminary yet and biological behavior has to be tested at larger sample numbers to draw any conclusion about biological characteristics and clinical relevance.…”
Section: Clinical Relevancementioning
confidence: 99%
See 1 more Smart Citation
“…EGFR amplification and/or overexpression are frequently diagnosed in high-grade gliomas but in some studies no association between amplification of EGFR and patient survival was seen [5,10], while other studies showed prognostic relevance of EGFR amplification for patient outcome [20,37]. In squamous cell carcinoma of the head and neck high levels of expression of EGFR are correlated with low radiosensitivity [16,32]. In our series the results are too preliminary yet and biological behavior has to be tested at larger sample numbers to draw any conclusion about biological characteristics and clinical relevance.…”
Section: Clinical Relevancementioning
confidence: 99%
“…Also genetic aberrations like EGFR gene amplification and TP 53 mutation or accumulation are correlated with worse outcome [8,29,32].…”
Section: Introductionmentioning
confidence: 99%
“…This radiationinduced EGFR autophosphorilation was prevented by the treatment of cells with a tyrosine kinase inhibitor. In addition, it has been observed that the radiation is less effective in inhibiting the growth of cells with high levels of EGFR than of those with low levels of EGFR [117]. Therefore, combining radiation therapy and EGFR targeted agents has been an actively pursued strategy.…”
Section: Association Of Radiotherapy With Targeted Therapymentioning
confidence: 99%
“…Moreover, activation of EGFR and downstream signaling pathways are implicated in cell survival and proliferation following radiation (21)(22)(23). High levels of EGFR expression appear to reduce radiation-induced apoptosis and to correlate inversely with radiocurability (24,25). Exposure of tumor cells to radiation results in immediate activation of EGFR by autophosphorylation (26) and a secondary prolonged release of TGF-alpha (23).…”
Section: Introductionmentioning
confidence: 99%