“…EGFR amplification and/or overexpression are frequently diagnosed in high-grade gliomas but in some studies no association between amplification of EGFR and patient survival was seen [5,10], while other studies showed prognostic relevance of EGFR amplification for patient outcome [20,37]. In squamous cell carcinoma of the head and neck high levels of expression of EGFR are correlated with low radiosensitivity [16,32]. In our series the results are too preliminary yet and biological behavior has to be tested at larger sample numbers to draw any conclusion about biological characteristics and clinical relevance.…”
Section: Clinical Relevancementioning
confidence: 99%
“…Also genetic aberrations like EGFR gene amplification and TP 53 mutation or accumulation are correlated with worse outcome [8,29,32].…”
In this small series of early passage glioma cell cultures low radiosensitivity and alterations in cell regulatory genes were seen. Further testing of biological behavior in larger series of patient-derived material is ongoing.
“…EGFR amplification and/or overexpression are frequently diagnosed in high-grade gliomas but in some studies no association between amplification of EGFR and patient survival was seen [5,10], while other studies showed prognostic relevance of EGFR amplification for patient outcome [20,37]. In squamous cell carcinoma of the head and neck high levels of expression of EGFR are correlated with low radiosensitivity [16,32]. In our series the results are too preliminary yet and biological behavior has to be tested at larger sample numbers to draw any conclusion about biological characteristics and clinical relevance.…”
Section: Clinical Relevancementioning
confidence: 99%
“…Also genetic aberrations like EGFR gene amplification and TP 53 mutation or accumulation are correlated with worse outcome [8,29,32].…”
In this small series of early passage glioma cell cultures low radiosensitivity and alterations in cell regulatory genes were seen. Further testing of biological behavior in larger series of patient-derived material is ongoing.
“…This radiationinduced EGFR autophosphorilation was prevented by the treatment of cells with a tyrosine kinase inhibitor. In addition, it has been observed that the radiation is less effective in inhibiting the growth of cells with high levels of EGFR than of those with low levels of EGFR [117]. Therefore, combining radiation therapy and EGFR targeted agents has been an actively pursued strategy.…”
Section: Association Of Radiotherapy With Targeted Therapymentioning
“…Moreover, activation of EGFR and downstream signaling pathways are implicated in cell survival and proliferation following radiation (21)(22)(23). High levels of EGFR expression appear to reduce radiation-induced apoptosis and to correlate inversely with radiocurability (24,25). Exposure of tumor cells to radiation results in immediate activation of EGFR by autophosphorylation (26) and a secondary prolonged release of TGF-alpha (23).…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.