2011
DOI: 10.1517/17460441.2011.611497
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Potential insight for drug discovery from high-fidelity receptor-mediated transduction mechanisms in insects

Abstract: Introduction There is a pervasive and growing concern about the small number of new pharmaceutical agents. There are many proposed explanations for this trend that do not involve the drug-discovery process per se, but the discovery process itself has also come under scrutiny. If the current paradigms are indeed not working, where are novel ideas to come from? Perhaps it is time to look to novel sources. Areas covered The receptor-signaling and 2nd-messenger transduction processes present in insects are quite… Show more

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